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Lysine User Reviews & Ratings

Brand names: L-Lysine, L-Formula

Lysine has an average rating of 8.9 out of 10 from a total of 118 reviews on Drugs.com. 86% of reviewers reported a positive experience, while 6% reported a negative experience.

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Reviews for Lysine

Commonly mentioned side effects
  • SWa...
  • August 4, 2021

For Herpes Simplex, Suppression "I have genital HSV-1. I saw really good reviews on lysine. Even though I hadn’t had an outbreak in 16-18 months, I decided to give lysine a go in hopes of suppressing it further. But a week after starting it, I got an outbreak. I think if I didn’t take lysine, I wouldn’t have had an outbreak. I don’t recommend this supplement for herpes at all!!"

1 / 10
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2 Report
  • NoL...
  • Taken for less than 1 month
  • March 13, 2018

For Herpes Simplex, Suppression "DO NOT TAKE LYSINE PILLS UNTIL YOU READ THIS. Once you start taking the pills, you cannot stop. If you get outbreaks a couple of times a year (that's not bad), once you take the pills and stop taking them later, you will start getting outbreaks every other week. DON'T DO IT. Just stick to the lysine cream and only when you start to have an outbreak. Most of the comments are from marketing companies paid to promote a certain vitamin or health product like grape seed extract will cure sinus infection and bad breath (no it won't). Even the strongest antibiotics that you've never heard of sometimes can't. Your body can defend itself against the herpes virus most of the time and keep it at bay (use a lysine cream when it can't). If you start taking the pills, your body will no longer fight the virus and it will start emerging frequently once you stop the pills."

1 / 10
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370 Report
  • Mic...
  • January 14, 2017

For Herpes Simplex (HSV) "This stuff is so awful, do not waste your time. I feel like it made my cold sores bigger and more painful. I am so mad that through all this pain and suffering, waiting for this medicine to work."

1 / 10
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4 Report

Frequently asked questions

  • PLE...
  • January 19, 2020

For Herpes Simplex (HSV) "DO NOT USE. This stuff completely depletes your body's own immunity to the virus, your body can't fight it alone once you've taken the recommended dose for even a couple of weeks. To make it worse, you have to keep upping the dose as the virus outsmarts it. If you stop even for one day or forget a tablet, the lysine can't gain control, becoming a never-ending battle that you will wish you never started. I now have extremely painful outbreaks every couple of days. The skin is red, raw, bleeding, and broken. It has ruined my job, my relationship, and my whole quality of life. Extremely high doses of antivirals do not even take the edge off because my body now has zero immunity. I also now have severe shooting pains down there and pain in the backs of my legs, making it difficult to walk. I would not wish this nightmare on my worst enemy. Please, I urge you, do not start taking these tablets, just let your body build up its own defenses because it will."

2 / 10
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27 Report
  • Bar...
  • Taken for less than 1 month
  • April 10, 2018

Lysine for Herpes Simplex, Suppression "I have IBS with alternating diarrhea and constipation. I tried L-Lysine a few months ago but thought it increased diarrhea and abdominal cramps. Continuing to break out, I tried the Lysine again, routinely twice daily. Unfortunately, the diarrhea and abdominal cramps have returned, and I'm stopping the Lysine immediately."

2 / 10
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26 Report

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  • Kk2...
  • Taken for less than 1 month
  • March 22, 2017

Lysine for Herpes Simplex, Suppression "One day after starting the L-lysine, I have horribly swollen lymph nodes in my underarms. It's been 3 days, and they are still painful and swollen. I did have smoothies each a.m. with mango and yogurt, which I read are high in lysine as well. I am stopping use due to this reaction."

2 / 10
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34 Report
  • Ali...
  • Taken for 10 years or more
  • July 3, 2017

For Herpes Simplex (HSV) "I tend to get blisters on or very close to my lips, which is embarrassing and impossible to hide. Lysine hasn't helped to quell my Herpes Simplex-1, albeit, it is surprisingly effective at decreasing the size and aggressiveness of the blisters. I've tried utilizing a daily dosage of ~1000 mg every day annually for three years paired with over-the-counter medications (Abreva, lysine creams) applied as soon as possible after noticing the dreaded tingle. I still managed to get seven to ten outbreaks annually, which was the same as before starting daily use. Therefore, I only take heavy doses (2-3000 mg daily) when I may be lacking sleep, sick, stressed, or going to be in the sun for a while. Usually, about a week before a possible outbreak and continue until it's healed."

3 / 10
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4 Report
  • Ken...
  • Taken for 1 to 6 months
  • September 4, 2021

For Herpes Simplex (HSV) "I recommend not using the 1,000 daily for an extended period of time. I had to stop taking it after I started suffering from unexplainable, frequent urination, where my doctor did every test in the book, from UTI to possible overactive bladder, despite me being only 24 years old. After everything came out inconclusive and negative, my doctor basically shrugged and sent me home. I was going to the bathroom 13 times, even 15 times, in a 24-hour period. It was driving me insane, and it was certainly not normal. I had been taking this supplement, 1,000 mg capsule daily for the last three months, every night. I stopped use, and in the 48 hours after stopping, my urine production has gone down greatly."

5 / 10
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8 Report
  • Mr ...
  • Taken for less than 1 month
  • June 27, 2020

For Herpes Simplex (HSV) "Began taking 500-1000 mg twice daily to suppress a recurrent sore/bump on the rear side of my palate. This increased greatly in recurrence due to immunosuppressive drugs for another condition. The lysine seemed to work for about a week, but now is possibly causing frequent stomach/gut pain and cramps. Might stop lysine and see if stomach cramps resolve, then resume dosing at a lower level, maybe 250 mg 2X daily. I skipped a dose or two to see what would happen, and the mouth sore came right back. But I'm not sure the stomach cramps are tolerable, since I already have Crohn's with a lengthy stricture..."

5 / 10
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3 Report
  • Sum...
  • Taken for 1 to 6 months
  • August 4, 2019

For Herpes Simplex, Suppression "If lysine is not effective, which it was not with me... magnesium is absolutely effective, and concentrated greens (powdered), such as Amazing Grass or any other reputable, similar product, or probably even eating dark leafy greens daily, will give you bioavailable magnesium through food. This will halt all symptoms completely. There’s no need for lab-produced amino acids when food will do the trick. Concentrated greens typically contain broccoli, kale, spinach, chlorella, etc., all FOOD, just dehydrated and ground up."

5 / 10
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33 Report
  • Cdi...
  • Taken for 2 to 5 years
  • April 17, 2019

For Herpes Simplex, Suppression "Been taking lysine for 2 years. Noticed an increase in outbreaks (HSV2). Symptoms and itchiness were lasting a lot longer. Currently having an outbreak. Not using lysine this time and I don’t even notice I’m having an outbreak until I look at it and safely apply Aquaphor to the affected area. Aquaphor is a way better home remedy."

5 / 10
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20 Report
  • H8D...
  • December 14, 2016

For Herpes Simplex (HSV) "Got herpes keratitis (cold sore in eye) twice. The ophthalmologist I was seeing would just prescribe me the same medications for the genital herpes. Even though the meds helped clear it from my eye, it wouldn't completely get rid of it. I'll still feel a bit of pain in my eye. So, I started using lysine. The 1st week using it, my pain went away. But wasn't sure if it was the lysine since I was using other OTC vitamins also (for my dry eye). But stopped using it last week and started feeling the pain again in my eye. Last night, I took 2/500 mg of lysine before sleeping and woke up with lesser pain. Was very surprised. Still experimenting with the dosage, so will be taking 2/500 mg, 3 times a day for maybe 3 days and slowly drop the dosage to only 2 times a day."

5 / 10
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11 Report
  • Hsv...
  • April 10, 2016

For Herpes Simplex, Suppression "Before I took lysine, I had an average of 1 or 2 outbreaks a year. I have been taking lysine for about 6 months, and just recently, I got two outbreaks back to back, a month apart."

5 / 10
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28 Report
  • San...
  • Taken for 1 to 6 months
  • May 7, 2022

For Herbal Supplementation "I've had no fever blisters, but I haven't had a period, and I've gained at least 10 lbs since beginning 1,000 mg lysine daily. I find that it gives me a little energy boost, but nothing life-changing. I'm concerned about my period not coming. I'm 39, so I think it should be happening, and it's always been regular."

6 / 10
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0 Report
  • Lou...
  • Taken for 1 to 2 years
  • October 31, 2019

For Herpes Simplex (HSV) "I have taken lysine many times, and while I started taking it daily to prevent cold sores, I started to feel like I had restless leg syndrome, and my feet started to hurt. This went on for weeks until I realized it started when I began taking the lysine. As soon as I stopped taking it, my legs and feet no longer ached. I figured I was getting too much in my body, so that must have been the reason. I haven’t taken it in a long time, and last night I took it again because I felt a blister coming. It prevented the fever blister, but the leg and foot pain returned. My experience is that it works great to prevent and reduce the duration of fever blisters, but it causes a lack of sleep because I keep having to stretch my legs during the night for relief, and my feet hurt."

6 / 10
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5 Report
  • Kei...
  • March 22, 2017

For Herpes Simplex, Suppression "64 years old, have occasionally had cold sores on the right corner of my mouth, once on my right nostril. My wife has had it since she's a child, also on her lips. Neither one of us gets it on our genitals. Starting to take L-Lysine 1000 mg a day and have still had a few outbreaks, but they have been less severe. When they occur, I am also taking a prescription of Valtrex. When I have the outbreak, I am increasing the L-Lysine dose to 1000 mg in the morning and the same at night. One of the side effects is good skin! I had a few bumps on my face that seem to be clearing up or going away. I wish I would have known about L-Lysine when I was a kid because it could be good for acne."

7 / 10
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31 Report
  • Som...
  • Taken for less than 1 month
  • August 31, 2022

For Herpes Simplex, Suppression "I use lysine to treat my herpes infection, and I noticed that the symptoms are reduced and the recovery is quick."

8 / 10
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3 Report
  • Cel...
  • Taken for less than 1 month
  • December 18, 2020

For Herpes Simplex, Suppression "Took lysine before bed, and the cold sore I have had is almost completely gone overnight!!!"

8 / 10
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13 Report
  • Tra...
  • Taken for less than 1 month
  • February 11, 2019

"I have chronic shingles. I had them for years before I was diagnosed. My doctor put me on daily suppression of Acyclovir, which works great, but a couple of times a year, they flare up, especially when I'm super stressed. I recently had a flare-up and called my doc, she suggested this supplement. Wow, what a difference! It helped with the pain, itching, and heal time. I won't be using it daily but will keep it on hand for flare-ups. It cut my heal time in half. Also, the protein arginine can make shingles or cold sores worse, so avoid arginine-rich foods like chocolate, nuts, gelatin, chickpeas, lentils, and eggs. This should help reduce breakouts."

8 / 10
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6 Report
  • HSV...
  • Taken for 2 to 5 years
  • December 4, 2017

For Herpes Simplex, Suppression "There is no cure for HSV2, but you can suppress it with lysine. You have to take it every day, and it just becomes part of your daily routine, like brushing your teeth or taking a shower. I was diagnosed with HSV2 in 2012 and had outbreaks every single month for the first year. After that, it was about every other month. It was a painful and humiliating experience for years. After introducing lysine, along with OLE, into my daily routine, I haven't had an outbreak since September 2015. If I feel like an outbreak may occur, I just up the dosage until that familiar tingling sensation goes away. I know lysine doesn't work for everyone, but I stand by it 100% for my HSV2 suppression."

8 / 10
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56 Report
  • bob...
  • Taken for 2 to 5 years
  • September 22, 2017

For Herpes Simplex, Suppression "Works incredibly well as prevention with 1g per day for oral herpes, then during occasional (and I mean years between last and current) up to 4g, and it disappears inside of a week. I managed to transfer my cold sore to the genital area, and it doesn't work as well there, but still aids an outbreak that can often take weeks to disperse. Get the bulk powder instead of tablets. The cost is greatly reduced, and you need only mix it with a splash of juice to drink it."

8 / 10
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20 Report
  • Sam...
  • January 6, 2017

For Herpes Simplex, Suppression "Having had the herpes virus all my life. It's a viral nightmare. Most people experience it in their lips. I'm one of the few (lucky ones) that experiences it in both ways, in my lips and my eyes. It's not nice... but people need to understand the causation. Late nights, stress (unconscious stress), poor diet, too much booze. For the 'lucky' ones who experience it in their eyes, I would say stress, stress, stress is it again. No real tricks involved, but when you get them, you kinda know why. Tiredness, poor nutrition, and stress. Wouldn't find it funny... but I cannot catch any other illness... flu, cold, man flu. Has to be an immunity thing. Lysine... I think could solve it. Regards, S"

8 / 10
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25 Report
  • 329...
  • March 1, 2016

For Herpes Simplex, Suppression "I have had HSV-2 for 20 years and just found out about lysine! I'm starting today and hoping that my outbreaks go away!!"

8 / 10
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30 Report
  • Kik...
  • Taken for 2 to 5 years
  • April 16, 2020

For Herpes Simplex, Suppression "I was getting small outbreaks occasionally for herpes and would take 1000 mg of lysine every few hours for the first day. Worked very quickly. If I get open sores that are very painful, I use a 40% zinc oxide baby diaper rash cream. Provides a barrier and helps immensely with pain and helps sores dry up fast."

9 / 10
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43 Report
  • Sam...
  • December 7, 2019

For Herpes Simplex, Suppression "I’ve had HSV-2 for 9 years, and have an outbreak a few days before my period - so I get tingles every month. Valtrex works in days, but L-lysine works in hours. If I start getting an outbreak, I take 2000mg every 2 hours until it disappears, and follow up with Valtrex the next day. L-lysine gets rid of the first sign of outbreak, as long as you overload on it. Love it, love it - especially when I’m low on Valtrex."

9 / 10
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84 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.