Immune globulin subcutaneous and Fatigue: What Users Say

• Ali...
• Taken for 1 to 6 months
• October 19, 2018

For Primary Immunodeficiency Syndrome "I infused Hizentra for 3 months, and although I had no infections during that time, my doctor took me off due to adverse side effects. I had flu-like symptoms such as severe fatigue and muscle and joint pain, and felt horrible every day. Eventually, I also had extreme kidney pain after every infusion. There are different stabilizers in each drug, and I was told I was probably allergic to the stabilizer in Hizentra. I switched to Cuvitru, which has a different stabilizer, and I am doing much better, with no pre-meds and minimal side effects. My IG levels are also higher on Cuvitru."

• Pip...
• Taken for 2 to 5 years
• July 23, 2022

For Primary Immunodeficiency Syndrome "I have been infusing Cuvitru subQ weekly in my thighs for more than 4 years, with no pre or post-meds. I started on Hizentra, which gave me many severe side effects, such as flu-like symptoms, probably due to an allergy to the stabilizer L-proline. My immunologist switched me to Cuvitru, which has a different stabilizer, Glycine. The only side effect I get is extreme sleepiness, so I infuse right before bedtime. During the 4 years, I have had two dose increases. My most recent IgG level in June 2022 was 1234, the highest it has ever been. My weekly dose is now up to 16 grams. I love infusing Cuvitru weekly because it is a smaller amount that takes less time, with fewer side effects. Infusing it weekly keeps my IgG levels more balanced out, so I don’t get lower trough levels before the next infusion that can cause severe fatigue for several days. I would recommend Cuvitru to anyone who has PI, especially if you have been on other products that have caused adverse side effects."

• Deb...
• Taken for 1 to 6 months
• July 4, 2025

For Primary Immunodeficiency Syndrome "I have gluten and dairy intolerances. Not entirely sure the diarrhea I have once or twice a week is from something I've eaten or from the Hizentra (weekly infusions). I feel lightheaded at times, but when one has an intolerance to the above, this symptom is common when I've had something I shouldn't have eaten. It's shortly after the lightheadedness that diarrhea occurs (next morning). Other than that, I fatigue easily, often sleeping 12 to 14 hours. Started Hizentra 4 months ago, so hopefully in another month or two will have more energy."