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Immune globulin subcutaneous Side Effects

For the Consumer

Applies to immune globulin subcutaneous: subcutaneous solution

Get emergency medical help if you have any of these signs of an allergic reaction while taking immune globulin subcutaneous: hives; wheezing, difficulty breathing; dizziness, feeling like you might pass out; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have:

  • signs of a blood clot in the brain--sudden numbness or weakness (especially on one side of the body), slurred speech, problems with vision or balance;

  • signs of a blood clot in the heart or lung--chest pain, rapid heart rate, sudden cough, wheezing, rapid breathing, coughing up blood;

  • signs of a blood clot in your leg--pain, swelling, warmth, or redness in one or both legs;

  • signs of a kidney problem--swelling, rapid weight gain, and little or no urinating;

  • liver problems--fast heart rate, tired feeling, dark urine, jaundice (yellowing of the skin or eyes);

  • lung problems--chest pain, trouble breathing, blue lips, pale or blue colored appearance in your fingers or toes; or

  • signs of new infection--high fever, flu symptoms, mouth sores, severe headache, neck stiffness, increased sensitivity to light, nausea and vomiting.

Common side effects may include:

  • redness, bruising, itching, and swelling where the medicine was injected;

  • nausea, vomiting, diarrhea, bloating, stomach pain;

  • tired feeling, headache, migraine;

  • mild itching or rash;

  • back pain; or

  • pain anywhere in your body.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to immune globulin subcutaneous: subcutaneous solution


Local side effects have been reported the most frequently. Up to 92% of patients reported adverse events at the injection site.[Ref]


Gastrointestinal side effects have been reported often (37%), including nausea (18%) and diarrhea (10%).[Ref]


Dermatologic side effects have included rash (17%).[Ref]


Hypersensitivity side effects have rarely included immediate anaphylactoid and hypersensitivity reactions. Allergic reactions (11%) have also been reported.[Ref]


General side effects have included headache (48%), fever (25%), sore throat (17%), and pain (10%).[Ref]


Respiratory side effects have included an increase in cough (10%).[Ref]


1. "Product Information. Vivaglobin (immune globulin subcutaneous)." ZLB Bioplasma Inc, Glendale, CA.

Not all side effects for immune globulin subcutaneous may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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