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Guaifenesin / pseudoephedrine and Insomnia: What Users Say (Page 3)

Brand names: Mucinex D, Mucinex D Maximum Strength, Ambifed-G, Congestac, Decongest II, Entex PSE, Guaifed, Degen II, ExeFen, Nalex CR, Mardrops-EX, Poly-Vent IR, Despec-Tab, Entex T, Guaimax-D, Anatuss LA, Fenex-PSE, G-Phed, Guaibid D, Nalex Jr, G-Phed- PD, Guaivent PD, Guaibid D Pediatric, Eudal SR, Duratuss GP (old formulation), Deconsal LA, D-Feda II, Guaifenex PSE 60, Demibid II, Guiadrine II, Guiatex II, Ambifed, Guiadrine II SR, Defen-LA, Desal II, Deco-D, GP 500, Guaifed-PSE, Guiadrine PSE 120, Guai-Vent/PSE, Guaifenex PSE 120, Guiatex PSE, Guai Sudo, Guaipax PSE, Ami-Tex PSE, Mucus D, Ru-Tuss DE, Guaifenex RX, Guaitab, Guiatuss PE Guaivent (Ethex) Tusnel Pediatric Drops Altarussin PE Sinutab Non Drying Robitussin Severe Congestion Humibid GC Guaifenex GP Dynex ExeFen-IR Durasal II Guiadrine PSE Guiatex II SR Coldmist Drituss GP Coldmist LA Coldmist Jr Guaifenex PSE 80 Aldex GS Despec-SR Guaifenex PSE 85 Maxifed Mucus Relief D Ambi 60/1000 Ambi 60/580 Ambi 80/780 Aquatab D Dose Pack …show all brand names

Reviews for Guaifenesin / pseudoephedrine

Commonly mentioned side effects
  • Unh...
  • February 2, 2017

For Cough and Nasal Congestion "I currently have the flu and am taking Tamiflu. My congestion and cough had me worried I would not be able to sleep, so I checked to make sure there wouldn't be any issues taking the Mucinex D while also taking Tamiflu. I took the Mucinex D at 8 pm and immediately felt like I couldn't go to sleep. I sat up on the phone for 2 hours listening to a discussion, trying to go to sleep. I finally did, only to wake up at 2 and be in the same situation I was in before. Unable to go to sleep, wide awake. Rest is the number one thing I need right now, and I'm not getting it because of the Mucinex D. I'm very unhappy with the drug."

5 / 10
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  • eri...
  • Taken for less than 1 month
  • January 3, 2024

Guaifenesin / pseudoephedrine for Cough and Nasal Congestion "I've used it before, and it works great. Maybe I always took it earlier, or it just got me different this time, but sitting awake at 4:30 am, not able to sleep and just realized why. Ugh. Take early to be sure you are not kept awake."

5 / 10
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  • Mam...
  • Taken for less than 1 month
  • January 10, 2022

Guaifenesin / pseudoephedrine for Cough and Nasal Congestion "Omg, I wish I had seen this site yesterday! I have COVID and saw recommendations to take this drug for the severe congestion. I took one yesterday morning and then again at 11 pm. I was WIDE awake all night. I slept from 4:30 to 6 am, that’s it. Omg, I was a mess, and no wonder, if I had known it had pseudoephedrine, I wouldn’t have taken it. Lesson learned: read the box. Now I get to parent young children while having COVID and no sleep, should be fun."

4 / 10
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  • Tob...
  • Taken for less than 1 month
  • February 28, 2018

Guaifenesin / pseudoephedrine "I was between getting this or Sudafed. Looked up pros and cons, and the main con of Mucinex with the decongestant was that you may have difficulty sleeping. I thought, “how bad could it be,” and went with Mucinex. Took it at about 9 pm. Slept for a bit at 11 pm, but it’s now 4:30 am and I’ve been wide awake since 2. It had a minimal effect on my symptoms. Now I get to roll, still feeling sick and with 3 hours of sleep. Not worth it at all, in my opinion."

1 / 10
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  • A b...
  • Taken for less than 1 month
  • January 20, 2021

Guaifenesin / pseudoephedrine for Cough and Nasal Congestion "I had to sing in a Christmas concert and was so stopped up that there was no way I would be able to sing. My doctor suggested taking Mucinex D and Claritin together. This turned out to be the best thing ever and has become my go-to solution when a sinus infection takes over my life. Obviously, don’t take it at night if you have sleeping issues, because the pseudo will amp you up, but this is a great option. It’s not a miracle drug, but it definitely helps you feel better. My only complaint is when you go to a pharmacy to purchase it, they treat you like you're requesting illegal drugs. They can tell how often you purchase it because they keep track of it no matter where you purchase it, so if you buy 18 pills every other year, it is completely ludicrous for this to be an issue."

10 / 10
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  • Anonymous
  • Taken for less than 1 month
  • January 28, 2018

Guaifenesin / pseudoephedrine for Cough and Nasal Congestion "This is my second day taking Mucinex for a bad cold. It’s not worth it! It has cleared my nose and throat completely, but I cannot get any sleep! Which is the pseudoephedrine side effect. I feel more miserable not being able to sleep than I did with the cold! On top of that, my heart has been racing for hours, and I started to get very anxious and nervous. I took this yesterday at 6 pm, it’s now 3 am, and I’m wide awake. Never again!"

1 / 10
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  • Anonymous
  • January 26, 2009

Guaifenesin / pseudoephedrine for Cough and Nasal Congestion "This medicine worked to relieve my nasal congestion, but it gave me severe insomnia. I stayed up for an entire night. I also experienced dry mouth."

5 / 10
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64 Report
  • Pam...
  • July 16, 2014

Guaifenesin / pseudoephedrine for Cough and Nasal Congestion "It works, but it's the pseudoephedrine that keeps you awake all night, tossing and turning, and I had that for about three days. I was physically exhausted but wide awake."

6 / 10
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40 Report
  • Moi...
  • January 10, 2015

Guaifenesin / pseudoephedrine for Cough and Nasal Congestion "Helped somewhat with congestion, but I could not continue to take it due to insomnia (even after taking it during the day), jitters, dizziness, and anxiety."

4 / 10
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  • Kd0...
  • Taken for less than 1 month
  • May 6, 2013

Guaifenesin / pseudoephedrine for Cough and Nasal Congestion "Very effective at relieving symptoms, but my husband and I both are experiencing insomnia and some anxiety with it."

8 / 10
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  • Awa...
  • November 27, 2013

Guaifenesin / pseudoephedrine for Cough and Nasal Congestion "Thankfully, I am no longer coughing, but after taking it at 11 pm and waking up at 2 am and not being able to go back to sleep, I'm wishing that I had read the reviews first."

9 / 10
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  • TT7...
  • March 20, 2015

Guaifenesin / pseudoephedrine for Cough and Nasal Congestion "It definitely kept me awake. It helped with the cough, but no matter what I did, I could not get to sleep."

4 / 10
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20 Report
  • Anonymous
  • October 14, 2012

Guaifenesin / pseudoephedrine for Cough and Nasal Congestion "Definitely helped to reduce my congestion. I took it at 7 PM and literally did not sleep at all that night. Had I known that this would happen, I would not have taken it in the evening."

6 / 10
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15 Report
  • Anonymous
  • July 31, 2012

Guaifenesin / pseudoephedrine for Cough and Nasal Congestion "My nasal congestion hasn't gotten any better, I've experienced no relief. However, I am writing this at 4 in the morning, so this medicine gave me both insomnia and shakiness/jitteriness."

1 / 10
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17 Report
  • NO ...
  • Taken for less than 1 month
  • September 28, 2017

Guaifenesin / pseudoephedrine for Cough and Nasal Congestion "It literally kept me up from 9 PM until 9 AM. I couldn't sleep at all."

3 / 10
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  • Raj...
  • January 29, 2013

Guaifenesin / pseudoephedrine for Cough and Nasal Congestion "Mucinex D is great. I have never had any insomnia or side effects from it. I follow the recommended dosage, which is one pill every 12 hours. I recommend this for everyone to try."

9 / 10
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11 Report
  • Anonymous
  • January 4, 2012

Guaifenesin / pseudoephedrine for Cough and Nasal Congestion "Definitely works great for my sinus congestion, but, like others, experienced insomnia and dry mouth. Took one pill at 6:00 in the evening. Probably better to take in the morning."

8 / 10
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7 Report
  • Thi...
  • March 12, 2015

Guaifenesin / pseudoephedrine for Cough and Nasal Congestion "I took Mucinex D 7 hours ago, and I can't sleep, and my sinuses didn't clear up a bit."

1 / 10
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9 Report
  • sle...
  • December 4, 2009

Guaifenesin / pseudoephedrine for Cough and Nasal Congestion "I am 235 lbs and took one at noon, and by 1:00 PM I was feeling great! I did not take another but still could not sleep that night, nor could my wife, who took one also. Almost a fair trade."

7 / 10
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  • Blu...
  • Taken for less than 1 month
  • August 1, 2017

Guaifenesin / pseudoephedrine for Cough and Nasal Congestion "It did the job of relieving my sore throat and massive headache. The bad thing is that I felt like a drugged-up zombie the entire night. Had to call out of work because of the insomnia :("

3 / 10
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  • Man...
  • February 3, 2011

Guaifenesin / pseudoephedrine for Cough and Nasal Congestion "Works very well with clearing up my nasal congestion, but I took it at night, and I am sleepless and jittery."

7 / 10
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3 Report
  • Jen...
  • Taken for less than 1 month
  • September 22, 2021

Guaifenesin / pseudoephedrine for Cough and Nasal Congestion "I never take that medicine again! I did not sleep and I thought I was going crazy."

1 / 10
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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.