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Enzalutamide and Headaches: What Users Say

Brand names: Xtandi

Headaches: mentioned by 3 users (7.3%)

Based on user experiences from 41 Enzalutamide reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

hot flashes 22.0%
tiredness 12.2%
fatigue 9.8%
back pain 7.3%
dizziness 7.3%
headaches 7.3%

Reviews for Enzalutamide

Commonly mentioned side effects
  • Gar...
  • Taken for less than 1 month
  • April 25, 2023

Enzalutamide for Prostate Cancer "78 years old with stage 4 prostate cancer. I'm on an Eligard injection to my belly fat every six months. PSA has been at point 3 (.3). Was put on Xtandi in addition to Eligard after not being able to tolerate Erleada because of bad headaches and extreme tiredness every time I took it. Had to stop Xtandi after two weeks because of extreme back pain between my shoulder blades that burst across my back if I coughed. I'm done with the add-ons due to quality-of-life issues. Will just stay with Eligard and take my chances."

1 / 10
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  • Ano...
  • Taken for less than 1 month
  • May 17, 2026

For Prostate Cancer "Headaches, vivid dreams, hot flashes from face to waist, stomach ache, constant nauseousness, constant bloating, slightly numb feet, itchy armpits. I've had to stop only 3 weeks in. I'm sorry, for some people it really is good. I haven't been able to take it because of the side effects. Also, I live alone and can't be sick all the time. The first week it was just hot flashes, which wasn't bad. But my third week I became very sick and had to stop. Can't say if it worked or not because I haven't had the PSA tests since taking it."

2 / 10
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  • Ern...
  • Taken for 1 to 6 months
  • October 8, 2026

Enzalutamide for Prostate Cancer "Hot flashes and less appetite, and also headaches, blurry eyes and body pains, sleeplessness."

6 / 10
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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.