Skip to Content

User Reviews for Doxylamine / pyridoxine to treat Nausea/Vomiting of Pregnancy

Also known as: Diclegis, Bonjesta

Doxylamine / pyridoxine has an average rating of 7.3 out of 10 from a total of 141 ratings for the treatment of Nausea/Vomiting of Pregnancy. 64% of reviewers reported a positive effect, while 22% reported a negative effect.

Doxylamine/pyridoxine Rating Summary

7.3/10 average rating

141 ratings from 143 user reviews.

Compare all 7 medications used in the treatment of Nausea/Vomiting of Pregnancy.

10
40%
9
14%
8
10%
7
7%
6
4%
5
2%
4
1%
3
5%
2
4%
1
13%

Reviews for Doxylamine / pyridoxine

Karen May 10, 2020

Bonjesta (doxylamine / pyridoxine): “I started having extreme nausea & vomiting at around 6 weeks pregnant. There was a point where just thinking about food would make me nauseous. Obviously I had forcefully eat because of the pregnancy but I knew it wasn't going to last, i just throw it back up. I would vomit 2 times a day and feel nauseous the whole day. My Ob told me about Bonjesta, I would take anything at this point. Turns out my insurance didn't cover it, it would be $700+ out of packet, I literally started crying because I was so tired of feeling the way I was feeling. But luckily, I got a prior approval and immediately after taking it I was able to keep my dinner down for the first time. I am on day 3 and currently have not thrown up or experienced nausea like i had been. Does make you really tired but I'd rather feel tired and fight through it than being nauseous all day and having the horrible feeling of hunger but not eating from fear of throwing up.”

9 / 10
Was this helpful?YesNo
IrishaR May 24, 2019

Diclegis (doxylamine / pyridoxine): “I was ridiculously sick starting around 5-6 weeks pregnancy. At 8 weeks my new Obgyn prescribed Diclegis. I started taking 2 pills at night and I definitely felt better next day - barely any nausea so it definitely served its purpose. However when I returned for the 10 week ultrasound my doctor informed me that there was no heartbeat and the baby stopped growing around 8 weeks. The heartbeat was strong 140 at 7 weeks and this was a totally devastating blow- usually once there is heartbeat above 120 there is a very small chance of miscarriage- about 3-4%. I can’t help but think that maybe it is not a total coincidence that the baby stopped growing and died right around the same time I started taking diclegis. If I am lucky to get pregnant again will never touch this drug :(”

3 / 10
Was this helpful?YesNo
Augustmama2020 · Taken for less than 1 month January 25, 2020

Diclegis (doxylamine / pyridoxine): “When I was originally prescribed diclegis I was told to take 2 at night and my zofran in the day as needed. After 3 more visits to the ER my doctor changed the dose from 2 to 4 a day. One in the morning, one in the afternoon and the 2 at night. This was the ONLY thing that worked to end my 24/7 nausea. It does make me super sleepy at times but I'll take that over constantly feeling like I'm dying ANYDAY. Feels good to be able to enjoy a glass of water and a snack without fear of vomiting and having stomach acid come up.”

10 / 10
Was this helpful?YesNo
Mary · Taken for less than 1 month April 22, 2020

Bonjesta (doxylamine / pyridoxine): “I am 9 weeks pregnant and have had horrible nausea and sometimes vomiting, zofran helped but is linked to heart defects in the babies so I was put on phenergan which helped but still didn't stop the nausea, which is when my OB put me on Bonjesta. Turns out, I had no idea what nausea, dizziness, and gut wrenching vomiting was until I started taking this medication! It made my symptoms so much worse, I've heard good things about it but want to let people know, it does not work for everyone! I have settled on phenergan it keeps my nausea at a reasonable level and I rarely vomit. Please stop taking bonjesta if you're getting dizzy and sick to your stomach!”

1 / 10
Was this helpful?YesNo
Mama of 6 September 11, 2018

Diclegis (doxylamine / pyridoxine): “I have Hyperemesis gravidarum (HG)! Have with all 6 pregnancies. My last pregnancy (my 5th) my dr gave me diclegis and it changed my whole pregnancy experience! My previous 4 pregnancies I suffered for 5-6 months constantly puking, weak, fatigued can't get out of bed, can't keep food or water down, in fact I have been hospitalized with every pregnancy for dehydration and was admitted for 3-5 day where the pumped me up with phenergan and zofran ( other nausea meds) I would feel a little better but the nausea was never gone! After my first dose of diclegis I immediately felt a difference! Let me be clear this is the only thing that has ever really helped take away the vomiting and nausea EVER I've tried everything! During my 5th pregnancy when I started taking the diclegis it was the first time I felt relief. I am now pregnant with my 6th child and I have started diclegis again because at 6 weeks I'm so sick with nausea and vomiting I can't get out of bed!”

10 / 10
Was this helpful?YesNo
Jess · Taken for 1 to 6 months October 27, 2019

Bonjesta (doxylamine / pyridoxine): “This medicine has honestly worked wonders for me. My morning sickness was so bad that it was through the whole day. I did read reviews prior to buying it and a lot people stated it makes you very sleepy. This is true. So I decided to only take one pill at night before bed and since it's an extended-release tablet it had helped with my sickness all the way up till the evening of the next day. It does knock me out for the night and I don't recommend taking it during the day if you work or have things to do. But it really does help with the sickness! I didn't have an appetite at all and barely could even drink anything...NOW I'm able to tolerate food and drink more. I don't have as much of an appetite like before being pregnant but am still able to eat a fair amount. If you're thinking and debating about the medicine just do it, it seriously does help if you take it continuously!”

8 / 10
Was this helpful?YesNo
Muffin · Taken for 1 to 6 months August 17, 2019

Bonjesta (doxylamine / pyridoxine): “I suffered from very bad hypermesis gravidarum (morning sickness) in my first pregnancy and had success in relieving symptoms with diclegis. During my second pregnancy I ended up having morning sickness again and was desperate for relief. My doctor prescribed me Bonjesta Which at first appeared to relieve symptoms but within two days I was just as sick as before. I ended up having to eliminate so many foods that by the time I was done I was only able to eat spinach and potatoes that were steamed. I decided to drop the Bonjesta and see what happened and within two days I had zero symptoms and was able to eat whatever I wanted. Imagine that, the anti nausea drug was causing my issues all along. This medication did not work for me at all. I’m glad that my insurance covered the medication because I would have been pretty sour about having to pay the exorbitant cost.”

1 / 10
Was this helpful?YesNo
SS · Taken for 1 to 6 months May 3, 2020

Diclegis (doxylamine / pyridoxine): “When I was around 6 weeks pregnant I was vomiting NON-STOP. It got to the point where I could not even hold down water. The doctor prescribed me Diclegis and it has been a MIRACLE drug. I take two tablets at night before I go to bed (caution that it does make you very sleepy) which I find an added perk because it helps me get a full nights rest. There are some mornings where I wake up still feeling slightly nauseous but I am not vomiting so the occasional slight nausea I can deal with. If you’re looking for something to make the 1st trimester nausea/vomiting disappear (or almost disappear) look no further because this is the drug for you.”

10 / 10
Was this helpful?YesNo
SMommy123 · Taken for less than 1 month December 2, 2018

Bonjesta (doxylamine / pyridoxine): “This is my first pregnancy and I have been extremely nauseated . Which started at week 6. At 8 weeks I was vomiting 3-4x a day. I am currently 10 weeks and my doctor prescribed me Bonjesta which has worked like a gem! I am forever grateful that their is a safe and effective method for women experiencing these symptoms throughout their pregnancy. I am hoping that as I move into the 12-14 week phase I will no longer have to rely on this medication but in the meantime I will continue to take it in order to function. It did make me extremely drowsy at first but now that I take it on a regular basis as prescribed my body has become some what adjusted. I typically take it in the evenings before bed.”

9 / 10
Was this helpful?YesNo
Prego · Taken for less than 1 month January 20, 2021

Bonjesta (doxylamine / pyridoxine): “Welll I came to the comments hoping it wasn’t just me, haha! I started bonjesta at 13 weeks and honestly I passed out the first night (can’t have nausea if you’re knocked out) so now I’m on day 4, it doesn’t put me out but it’s like it amped it up. I’ve thrown up 3-4 times a day and soon as I put food on my tongue, I get gaggy and chills and end up not eating. I’ve been living on crackers and chips then I throw those up. I tried a smoothie yesterday and ended up puking it all back up. Please tell me it’s almost over lol”

5 / 10
Was this helpful?YesNo
E · Taken for less than 1 month July 20, 2019

Bonjesta (doxylamine / pyridoxine): “This is my 5th pregnancy and I always have nausea, but not technically severe because I don’t vomit. But this time I have been nauseous pretty much 24/7 with severe food aversions. I am 8 weeks and we had a plane trip already scheduled, so I asked my doctor for something because I struggle with motion sickness even when I’m not pregnant. Oh my goodness, I have NEVER felt so good on an airplane in my life! My nausea is completely gone and food sounds good again. Three days ago looking at food magazines made me feel queasy. For me drowsiness hasn’t been an issue either. They just gave me a sample of Bonjesta, but I think I’m going to ask for a prescription when we get home. I feel like myself again and like I can actually be there for my kids, instead of just laying on the couch trying not to think about food.”

10 / 10
Was this helpful?YesNo
Humi · Taken for 1 to 6 months May 17, 2019

Diclegis (doxylamine / pyridoxine): “Okay so last time I wrote a review (2019-04-25) I was just put on diclegis and my review might not move some people but today after taking it for one month I can say girls if you are pregnant and you have nausea then you deserve this medicine. Ask for samples if you want to give it a try before buying and please if Unisom and Vit b6 doesn’t work day one it won’t ever work on you I wasted two weeks on it. Also if reglan made you sick like it did to me throw the pill and ask for Diclegis and I'm sure it will help but above all lies help of God I thank him that I can have this medicine and be happily pregnant .”

10 / 10
Was this helpful?YesNo
vanessa3427 June 3, 2013

Diclegis (doxylamine / pyridoxine): “I have always had horrible morning sickness. This time around I am pregnant with twins and it was much worse. I started the medication and it stopped the ache of nausea all the time! The bad is it did stop the nausea but I had no signs when I was going to throw up. So you randomly throw up without knowing your stomach is upset..not fun at All. The bad thing is with the co-pay with my insurance was $160, so very pricy but worth it.”

8 / 10
Was this helpful?YesNo
Angela · Taken for less than 1 month April 30, 2020

Bonjesta (doxylamine / pyridoxine): “I was put on Bonjesta at 10 weeks pregnant. I was put on Zofran first and took it for a week with no help, then phenergan for a week, same thing. The only thing I could stomach was a banana a day and a sip or two of ice cold water or sprite. I was puking and vomiting every single day. I had lost 12lbs from lack of eating and constant puking. Bonjesta's been a life saver. I've been able to eat.The only side effect I've had, is tiredness. Taking it at night has been the best for me. I'm so happy to be back to "normal." I am able to be full now, along with knowing I'm getting and giving the baby the food, vitamins and nutrients like it needs. If you're losing weight while pregnant, constantly puking and sick, and can't eat, I highly suggest talking about Bonjesta with your OB and see if it may work for you.”

9 / 10
Was this helpful?YesNo
Humi August 5, 2020

Diclegis (doxylamine / pyridoxine): “So the first time I took Diclegis I was around 8 weeks pregnant, and it worked wonders I couldn’t relate to negative feedback here, but now with my second pregnancy it doesn’t work like the first time, I still throw up I’m still nauseous I hate smell and sight of food but I’m not going to say I’m as miserable as I was with my first pregnancy without this drug, maybe because I’ve been here before so I know what to eat and what to avoid or maybe it’s Diclegis working 20 percent only I hate to say this but ladies .. it doesn’t work every time”

3 / 10
Was this helpful?YesNo
ksocks47 · Taken for less than 1 month March 24, 2015

Diclegis (doxylamine / pyridoxine): “I want to throw a ticker tape parade for the manufacturers of this medicine. It changed my life. I'm 13 weeks and was flat on my back gagging all day every day. I tried all the tricks and nothing worked until I tried this. I am back in the land of the living and hoping to regain the 10 lbs I lost in the 1st trimester. I did A LOT of research and there is nothing that indicates that this medicine causes any problems whatsoever for baby. It is probably the best researched medicine on the market to date. Emily Oster's book Expecting Better has a nice explanation for why it was pulled in the US (but not UK or Canada) for 30 yrs.”

10 / 10
Was this helpful?YesNo
Brittmariah · Taken for 1 to 6 months December 16, 2017

Diclegis (doxylamine / pyridoxine): “So I suffer from hyperemesis gravidarum (HG) (severe nausea and vomiting) I was prescribed zofran with my first pregnancy and the birth defects that were listed that could effect my baby, effected my baby. I was so angry and upset with my doctor for telling me it was safe to take. My daughter now has a heart defect. Second pregnancy, I suffered so much more than my first. I found a new obgyn and he prescribed me Diclegis. I will say this, it’s a life saver. I was vomiting 20-25 times a day and the nausea never went away. I couldn't drink or eat anything I lost 15 lbs in 3 weeks. This drug is the only thing that is safe during pregnancy and it was the only drug that works. I would only recommend this to anyone that suffers from HG.”

9 / 10
Was this helpful?YesNo
Anonymous January 16, 2019

Diclegis (doxylamine / pyridoxine): “This medication was a life saver. I went to the ER twice with dehydration from severe vomiting. I couldn’t keep any food or water down. I was diagnosed with HG and sent home with a prescription for diclegis and zofran. I did not take the zofran, but took the diclegis religiously. It didn’t stop me from feeling ill right away, but it too the edge off and I could continue to work. I was still nauseous but able to eat again. After a month on the medicine I was gaining weight (after having lose 15lbs of prepregnancy weight) and I was eating like a champ! Yes, this medicine does make you EXTREMELY tired, but I’d rather fight the day tired than throwing up. (25weeks and still taking it because I’m still sick)”

10 / 10
Was this helpful?YesNo
Mrs.Dupre · Taken for 1 to 6 months November 10, 2013

Diclegis (doxylamine / pyridoxine): “I started taking this medication three weeks ago and it works great for morning sickness but they don't tell you the risks they say it is safe for both you and the baby yet I started having severe chest and back pain and had blood work done over and over and they told me I was fine but I hadn't had a bowel movement in almost two weeks and I was in so much pain I couldn't get out of bed......but i found out it was the reason for all my problems, restless sleep, chest pain, back pain, not being able to stand or take care of my children it was not worth the pain and the suffering and imagine what you baby is going through if your in all that pain. There is a reason it was off the market for 30 years.”

6 / 10
Was this helpful?YesNo
Anonymous · Taken for less than 1 month October 1, 2020

Bonjesta (doxylamine / pyridoxine): “I had morning sickness all day long. It kicked in on week 6. It was unbearable. I tried bonjesta For three days and it took the edge off. I was disappointed because I was still super nauseous. I took a second pill on the fourth day. It made me sooooo drowsy. After taking two, I went back to one a day. After a week on it, I feel soooooo much better!! My nauseous was almost completely gone after a week, and it doesn’t make me drowsy anymore. If after a few days it’s doesn’t work, take a second pill one day just to get in you system and wait a week. It takes a week to work. It is worth it! You will feel good again.”

10 / 10
Was this helpful?YesNo
YmendeZ October 30, 2015

Diclegis (doxylamine / pyridoxine): “I was completely disabled by my nausea. I had zero appetite, simple tasks seemed impossible and went 2 weeks without working. At approx 7 weeks my doctor prescribed Diclegis. I must say I was extremely hesitant but after another week of constant nausea I decided I would give in. The change has been miraculous. I can sleep better, have an appetite (limited to salty or sour things only) and nausea almost completely gone. After a few weeks or taking Diclegis, I decided to test not taking one night and spent a full day in bed with nausea and not being able to eat. Later that night I took my 2 pills again and next day feeling absolutely wonderful. This medication is a life saver.”

9 / 10
Was this helpful?YesNo
Brina01 · Taken for less than 1 month January 16, 2017

Diclegis (doxylamine / pyridoxine): “I was given samples of Diclegis to help with my all day sickness. It seems safe so I was pretty excited to take it. First night took 2 pills and the next morning no nausea but I was dead tired, had dry mouth, and had stomach aches. Literally felt like a zombie couldn't drive barely made it out of bed. I had to stop taking it because I can't miss work. The next day I had a severe migraine never had one prior. It could have been due to me stopping the medication or it wearing off but I couldn't see nor function. I'd rather deal with the nausea than the side effects honestly. I feel bad but cannot function on Diclegis. Pregnant women are already tired we don't need to add to it. I'm glad it's working for others but thought I'd share my experience.”

1 / 10
Was this helpful?YesNo
My sanity saver! · Taken for less than 1 month August 15, 2017

Diclegis (doxylamine / pyridoxine): “This drug has saved me from going insane because of how ill I was. I suffered from severe Nausea and vomiting in pregnancy. Throwing up for weeks on end, I would throw up every few hours. I went days without being able to keep anything down, including water. Those who suffer from NVP, I know your suffering... it is so awful! I was stuck on the couch and in bed for over a month and then I finally decided it was time to go on medicine. My quality of life was 0 before this medication. This medicine is definitely on the spendier side but worth every penny if you are suffering. If this medication didn't exist I would no doubt be in the hospital.”

Was this helpful?YesNo
Alyssa May 3, 2019

Bonjesta (doxylamine / pyridoxine): “Bonjesta helped immediately. After dealing with nausea and vomiting starting at week 5, I realized it would have been impossible to get myself out of bed and into work. I wasn’t able to keep water down. Was dehydrated. Weak. My doctor prescribed this immediately and it got rid of probably 90% of the nausea and vomiting.”

10 / 10
Was this helpful?YesNo
2nd baby · Taken for less than 1 month August 24, 2014

Diclegis (doxylamine / pyridoxine): “I'm 4 months along with my second child. This pregnancy is very different from the last. I never had such bad nausea, vomiting and dry heaving. I'm taking thus medicine in an as needed basis. So far I need one pill at night and another about mid morning. The original prescription said one morning, one mid day and two at night. I did that once and slept until 2 pm the next day. That's not healthy either. The only complaint I have is the cost. It ran $178.53 for us. A cost that wasn't expected but when Phenergren and Zofran isn't working....you give in. Just as every OTC or prescription, there are side effects. For me the benefit outweighs the risk. Try to stay away from medication until at least 13 wks.”

10 / 10
Was this helpful?YesNo

This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare professionals.

Learn more about Nausea/Vomiting of Pregnancy

IBM Watson Micromedex

Mayo Clinic Reference