Collagenase clostridium histolyticum and Pain: What Users Say (Page 2)

• kli...
• August 27, 2020

For Dupuytren's contracture "Had a more than 90-degree contraction. The injection is painful, but I had no bruising. The injection of the anesthetic was very painful. Manipulation of the finger resulted in a definite snap of the cord, but the result was very disappointing. Only gained about 20 degrees. Sitting with an extremely swollen and painful hand two days later."

• Ric...
• Taken for 1 to 6 months
• March 5, 2023

For Peyronie Disease "I saw results after the first round of treatment, but after the second round, went from a 60-degree to a 20-degree curve. I am on my 4th and last round, and I am at an 18-degree curve. The first round of 2 shots is bad. On the first day, you get 1 shot to erect the penis, and the 2nd shot brings it down, then you get the Xiaflex shot. I will not lie, all 3 shots hurt for a few seconds, and it is unpleasant. But so far, it is worth the few seconds of pain. I hope after this round back to normal or close to it. It made my sex life great, and my wife is happy with the results. I went on a website and got a grant for Xiaflex. Between insurance and the grant, it cost $0 for Xiaflex, but I had to pay for the medication to erect my penis and one to bring it down, which cost about a total of $150.00."

• Son...
• Taken for less than 1 month
• August 11, 2021

For Dupuytren's contracture "I am only one day post-manipulation, so I’m not sure of my lasting results. But I would not do it again, due to the pain and the tearing, even though my insurance covered the injection 100%. I had it done to my severely bent ring finger, which has been operated on twice before. The tearing was predicted, but the pain of the Xiaflex and local numbing agent was unimaginable."

• Did...
• Taken for 1 to 6 months
• December 28, 2022

For Dupuytren's contracture "I saw the hand specialist for my right 5th finger. I originally asked for surgery and was basically bullied into the Xiaflex treatment. I was told it would be less painful and a better outcome overall. I went in for an initial injection in my right 5th digit with over 50% contracture in May 2022. The injection was painful, but not horrible. My finger was wrapped, and I did experience pain in the digit and up to my armpit. I went back for the manipulation 2 days later. Again, the injection to numb the digit was painful, and I did not feel the cord tear. I asked the physician about this and was advised it would be 'OK.' I wore the splint on a regular basis, and as of December of this year, my finger is still contracted and the cord going into my palm is now more palpable than before. After all the time, expense, and pain, I don't feel Xiaflex is helpful at all. I would not waste my money on this treatment."

• Anonymous
• July 21, 2021

For Dupuytren's contracture "I had my right hand done with the injection Xiaflex, and it was very painful and not a success. A few months later, I had surgery on the pinky finger and therapy, and it’s straight. In March, I had the injection done on my left hand, and again, very painful."

• Ahm...
• Taken for less than 1 month
• January 28, 2022

For Dupuytren's contracture "I have pain in my right wrist and have Dupuytren's contracture in my right palm. The right ring finger was slightly bent about 10-15 degrees. The doctor told me the pain is caused by the contracture. He gave three Xiaflex injections in my right palm, which were quite painful. Then, three days later, he stretched the finger under local anesthesia. The result was a disaster. The small finger bent much more than before, about 45 degrees. I have to first straighten the small finger before I can do anything with my hand. The pain in the wrist is still there. I do not know whether the injection was incorrectly administered or the Xiaflex itself caused it. Please read all the reviews before deciding on this injection. I personally would not recommend it."

• Eri...
• Taken for 1 to 2 years
• September 9, 2021

For Peyronie Disease "I’m very surprised by the bad experiences. Fortunately, my experience has been good. I’ve had 3 series. I completed shot 1 of the 3rd today. I’ve never had a reaction, but on the way to the car, I had pain from my sacrum to my knees. I had to wait a bit before driving home. Not sure what that was about. As far as success, some length loss, but girth returned and has straightened. I’ve been pleased."

• And...
• Taken for less than 1 month
• November 25, 2021

For Dupuytren's contracture "Excellent results, although done early in progression with right hand. 4th digit bent slightly near tip and 5th digit permanently bent and frozen at 1st joint. This condition had been progressing slowly over the past 12-18 months. I straightened and massaged on my own on 1st day after the procedure without numbing. I did not understand this would be done painlessly with numbing on the 2nd day. I heard large 'pops', but with searing pain during this. I'll know better next time. But it seemed to be effective, and I can honestly say I am 100% normal. I still have thick areas on my palm and between my 4th & 5th digit from when the MD split the skin after numbing and over-adducting these fingers apart. Left hand was too severely progressed, and without attempting to use Xiaflex, surgery was performed. My 5th digit was unable to be straightened fully and over the past 5 years has regressed. 4th digit on left is slightly bent near the tip. I hope we can try Xiaflex on left hand."

• Dix...
• November 8, 2022

For Dupuytren's contracture "I had the injection done after my pinkie and ring finger became significantly contracted. I was assured that my research saying it could be a quite painful procedure was wrong. In fact, it was incredibly painful, and I had swelling and severe bruising in my entire hand and arm, clear up to my underarm and lymph nodes; the doctor's response was that I had had an abnormal reaction. The waiting period between the injection and manipulation kept me awake with nerve pain. My fingers straightened, but in the five months since the procedure, I have weakness, aches, and pain in the arm where it bruised. While it appears I need the procedure in the future in my (dominant) right hand, I am extremely hesitant to even consider it and will likely evaluate other options."

• Anonymous
• Taken for less than 1 month
• August 12, 2022

For Dupuytren's contracture "Very painful and creepy. Hand mangled, bruised, skin ripped open. Took time off work, wore a splint at night. A year after, it came back with a vengeance. Twice the scar tissue, fingers crooked up even more."

• Dia...
• Taken for 1 to 6 months
• July 14, 2021

For Dupuytren's contracture "Had left hand done in May and now having right hand manipulated tomorrow. Xiaflex injections are somewhat painful but worth it. The local injections are worse but tolerable, manipulation is nothing. Had minor bruising but no problems otherwise. My right hand has swollen and been a little more painful since the Xiaflex injection earlier, but I am right-handed and use it more. Find a good doctor and get this done, nothing to it!"

• fir...
• Taken for less than 1 month
• June 10, 2022

For Dupuytren's contracture "It hurts like anything, but is well worth it. Pain is only while you are receiving the injections. Almost normal after 3 days. I think finding a doctor that does this a lot is key and catching it early. My shots were paid for by a grant, except for $150, which the company selling the drug took care of."

• Anonymous
• Taken for 2 to 5 years
• January 29, 2025

For Dupuytren's contracture "I had the procedure done in February 2023, 2 years ago now. Must have had a good doctor because although I do remember pain during the procedure, it was very bearable and quick. Before the procedure, my ring finger was curved dramatically, and the fingers on each side of it were also being pulled over. After the procedure, I estimate 85-90% improvement in the ring finger and almost 100% in the other two. The thick chord is still going through the middle of my hand. Over the last two years, there has been a slight increase in the curvature of my ring finger, but performing the exercises given to me post-procedure seems to immediately straighten it. I really should wear the hand splint at night because it does seem to temporarily help when I do. I would recommend it as an alternative to surgery, which can be bad, and talk to a doctor about programs to help reduce the out-of-pocket cost. My doctor was very helpful with that! He told me that it was likely to return maybe 10 years?"

• Ale...
• Taken for less than 1 month
• September 6, 2022

For Dupuytren's contracture "I had it done 5 years ago (the first finger hurt like hell, the second finger I demanded a local). So now one finger is fine and the other is about 20 degrees but okay. So now I have 3 more fingers that are problematic and I go in tomorrow with apprehension due to the pain... local will be demanded. Also, after the first finger was done, I had pain for a couple of weeks. The second finger was fine???"

• Tim...
• July 26, 2022

For Peyronie Disease "I went through the entire series of 8 shots and no change to my 70-degree upward curve, just pain and bruising."

• Anonymous
• Taken for less than 1 month
• May 28, 2023

For Dupuytren's contracture "Had this procedure done 2 weeks ago, and it’s coming back. Waste of time and money. Extremely painful and stressful."