Collagenase clostridium histolyticum and Bruising: What Users Say

• Sad...
• Taken for 6 months to 1 year
• March 24, 2020

For Peyronie Disease "I went through 6 series of shots. A series consisted of getting a shot, waiting 2 days, getting another shot. Then you wait 5 weeks and start the next series. Each time after getting the first shot, my penis, scrotum, and entire groin area would bruise badly. A real struggle to go in 2 days later for that next shot... Literally, one of the hardest things I've had to do in my life was lie there while a needle was stuck in my penis. But getting rid of that curve? Totally worth it - if it had worked, but it didn't. Unlike some of the other reviewers, I guess I should be grateful it's not worse."

• Ano...
• Taken for less than 1 month
• May 2, 2025

For Dupuytren's contracture "Didn't work for my Dupuytren's in left ring finger and pinky. The cord was broken in my palm after being manipulated, which was after the injections of Xiaflex. Left hand became very swollen and bruised after the injections. Two weeks later, I can't see much at all improvement. Glad I tried it, but won't do it again. Not worth the pain, stress, and possible really bad side effects. I'm 79."

• Ano...
• April 2, 2021

For Peyronie Disease "It's been 9 months and 2 injections every 6th week. No discomfort after initial injection. Always bruised for a few days. Went from 75% curvature to 50%. Opted to continue. Must go to an expert in this field. The details are important. The stretcher must be from Mayo Clinic. Must adhere to wearing it as directed. The stretcher allows growth of good tissue in the right area. My doctor has treated over 5,000 patients from all over the world. UCSF has their own PD unit. Highly recommend."

• Anonymous
• Taken for 6 months to 1 year
• September 3, 2020

For Peyronie Disease "Don't waste your time or money. I went to my urologist for the treatment, who was excellent. Little bruising or discomfort with the injections. After 4 courses of injections over several months, NOTHING. I even purchased an expensive traction device and followed the instructions perfectly.... The only option for this disease, unfortunately, is surgery if you want any results at all. So glad my health insurance paid for this as it's VERY expensive and ineffective."

• Xia...
• Taken for 1 to 6 months
• January 17, 2020

For Peyronie Disease "Terrible experience with Xiaflex! This is a very bad drug! It left me worse than I was! I wish I would have never done this. I felt a burst, worst bruising ever. So very painful! I still don't feel right, this has messed me up big time! This drug should not be used for this! Rating this drug as a 1 is too high!"

• Anonymous
• Taken for less than 1 month
• December 24, 2019

For Dupuytren's contracture "I would not recommend this procedure at all. I had a reaction to the injection, which caused bruising on my arm up to my armpit. It felt like my whole right side of my body was just not quite right, however, my Dr. said that it just couldn't be from the shot. It is a week and a half later, and my arm still hurts, and my little finger is bruised, swollen, and aches. The procedure was painful, and the manipulation of my little finger three days after the shot hurt, and I felt the tearing of the cord or whatever. My finger is still so swollen and bent that I'm not sure how straight it will be after it heals up, hoping upon hope that it actually heals and I can use it again. Again, I would not ever do this again!"

• Las...
• Taken for 1 to 6 months
• January 14, 2022

For Dupuytren's contracture "DO NOT GO THROUGH THIS PROCEDURE! Money grab for the docs - more so than surgery. Awful pain for weeks and incredible bruising in my arm but felt it all the way to my right foot and groin. My husband referred to it as POISON - which I agree 100%. It’s been 2 months and the finger is retracting back in. I will never do this again - do the surgery instead!"

• Nev...
• May 11, 2021

For Dupuytren's contracture "Extremely painful and the outcome was no correction. The side effects were relentless itching after the painful injections, my hand and arm swelled 2x its normal size for a week after injections, and my hand was so painful I couldn’t even touch it. It’s only been two weeks and I am still experiencing pain and bruising. This drug should be taken off the market, in my opinion. A waste of time, money, and unnecessary complications for absolutely no reason! I’ll turn to amputation before I would ever do this treatment again."

• Car...
• February 19, 2021

For Peyronie Disease "I am a 56-year-old male of good health. Just finished my 3rd round of therapy, including modeling. I had a 45-degree curvature, which is now 20% and very functional and manageable. I had a good urologist that followed the recommended protocol to the letter. Although the injections were painful initially, I was able to tolerate them more in the subsequent series. Furthermore, I had my doctor provide me with a Novocaine numbing cream about 5 minutes prior that reduced injection pain considerably. Make sure you ask for that, as it makes a considerable difference. I did have some bruising after each injection, but it always cleared up within a week and was manageable. I am very happy with the results so far and will see him in two months for a Trimex evaluation to determine whether I want to proceed any further. I would recommend this therapy. However, find a good urologist, and do all of the home modeling he recommends between series and beyond so you continue to stretch and reform."

• Anonymous
• Taken for less than 1 month
• August 12, 2022

For Dupuytren's contracture "Very painful and creepy. Hand mangled, bruised, skin ripped open. Took time off work, wore a splint at night. A year after, it came back with a vengeance. Twice the scar tissue, fingers crooked up even more."

• Dia...
• Taken for 1 to 6 months
• July 14, 2021

For Dupuytren's contracture "Had left hand done in May and now having right hand manipulated tomorrow. Xiaflex injections are somewhat painful but worth it. The local injections are worse but tolerable, manipulation is nothing. Had minor bruising but no problems otherwise. My right hand has swollen and been a little more painful since the Xiaflex injection earlier, but I am right-handed and use it more. Find a good doctor and get this done, nothing to it!"

• Tim...
• July 26, 2022

For Peyronie Disease "I went through the entire series of 8 shots and no change to my 70-degree upward curve, just pain and bruising."