Collagenase clostridium histolyticum and Swelling: What Users Say

• Fre...
• Taken for 6 months to 1 year
• November 10, 2022

For Peyronie Disease "I was on my LAST injection, and it sent me to the ER! The other 7 injections did NOTHING! I’m in so much pain and misery right now! I can barely walk! Swelling and discoloration are the worst right now, and every time I walk, it feels like my penis is in a blender or being twisted by a psychopath! How is this product so expensive and 'safe'?"

• 1st...
• Taken for 1 to 6 months
• June 4, 2021

For Peyronie Disease "I have completed my 3rd series of Xiaflex, 6 shots... WASTE OF TIME!! Not to mention the pain and swelling. I now have more of a curve in my penis than when I started. Scheduled for a fourth series, but I will not be going. There has to be a better way. I just hope I haven't gone so far that I cannot fix it."

• LA ...
• November 13, 2020

For Dupuytren's contracture "Had Xiaflex injection mid-August, it's now the end of November. The injection procedures, both Xiaflex drug and Novocain numbing, are the most painful things I have ever experienced. Feel like I survived torture. The first week after the injection, my left hand and arm were swollen, and my arm turned red, purple, green, then yellow for about two weeks. The drug is very expensive, and the copay was almost $2,000. After over three months of PT and wearing a splint at night (and any other time I'm not using my hand), my fingers curl back to the original 50-degree bend. Concluded that the procedure did not work. DO NOT HAVE THIS PROCEDURE. INTEND TO COMPLAIN TO AUTHORITIES-FDA, PHYSICIAN LICENSING, WHOEVER WILL LISTEN."

• Ano...
• Taken for less than 1 month
• May 2, 2025

For Dupuytren's contracture "Didn't work for my Dupuytren's in left ring finger and pinky. The cord was broken in my palm after being manipulated, which was after the injections of Xiaflex. Left hand became very swollen and bruised after the injections. Two weeks later, I can't see much at all improvement. Glad I tried it, but won't do it again. Not worth the pain, stress, and possible really bad side effects. I'm 79."

• Tom...
• Taken for 6 months to 1 year
• January 28, 2022

For Peyronie Disease "After two rounds of Xiaflex, I can say I’ll never have a third. Never recommend to anyone, no matter how bad your PD is. The pain, swelling, blisters, and bleeding are an 11 on a scale of 1-10. Nothing is worth what this horrific drug has done to me."

• Anonymous
• Taken for less than 1 month
• December 24, 2019

For Dupuytren's contracture "I would not recommend this procedure at all. I had a reaction to the injection, which caused bruising on my arm up to my armpit. It felt like my whole right side of my body was just not quite right, however, my Dr. said that it just couldn't be from the shot. It is a week and a half later, and my arm still hurts, and my little finger is bruised, swollen, and aches. The procedure was painful, and the manipulation of my little finger three days after the shot hurt, and I felt the tearing of the cord or whatever. My finger is still so swollen and bent that I'm not sure how straight it will be after it heals up, hoping upon hope that it actually heals and I can use it again. Again, I would not ever do this again!"

• Nev...
• May 11, 2021

For Dupuytren's contracture "Extremely painful and the outcome was no correction. The side effects were relentless itching after the painful injections, my hand and arm swelled 2x its normal size for a week after injections, and my hand was so painful I couldn’t even touch it. It’s only been two weeks and I am still experiencing pain and bruising. This drug should be taken off the market, in my opinion. A waste of time, money, and unnecessary complications for absolutely no reason! I’ll turn to amputation before I would ever do this treatment again."

• kli...
• August 27, 2020

For Dupuytren's contracture "Had a more than 90-degree contraction. The injection is painful, but I had no bruising. The injection of the anesthetic was very painful. Manipulation of the finger resulted in a definite snap of the cord, but the result was very disappointing. Only gained about 20 degrees. Sitting with an extremely swollen and painful hand two days later."

• Anonymous
• Taken for less than 1 month
• August 31, 2021

For Dupuytren's contracture "Made my 2nd and little finger have a bend in them at the big middle joint that won't straighten out now. Overall, fingers in the right hand seem swollen on the underside and extremely sensitive to touch. My hand has lost the grip it had before the injections. Now I know why you can't get it from the USA into Canada anymore. There should be a class action lawsuit over this poor drug that does more damage than good."

• Dix...
• November 8, 2022

For Dupuytren's contracture "I had the injection done after my pinkie and ring finger became significantly contracted. I was assured that my research saying it could be a quite painful procedure was wrong. In fact, it was incredibly painful, and I had swelling and severe bruising in my entire hand and arm, clear up to my underarm and lymph nodes; the doctor's response was that I had had an abnormal reaction. The waiting period between the injection and manipulation kept me awake with nerve pain. My fingers straightened, but in the five months since the procedure, I have weakness, aches, and pain in the arm where it bruised. While it appears I need the procedure in the future in my (dominant) right hand, I am extremely hesitant to even consider it and will likely evaluate other options."

• MFK...
• October 9, 2022

For Dupuytren's contracture "I was treated for Dupuytren contraction for the ring and pinky finger on my left hand. I had significant discomfort with the Xiaflex injection on fingers, subsequent swelling of the left hand, and minor discomfort in the left armpit, which also turned red. However, after two weeks, the improvement to the fingers has been almost 100%, and it appears to be continuing to improve. Hopefully, I never have to have it again. However, if necessary, I would. Be advised, I’m a 69-year-old male in good health."

• Dia...
• Taken for 1 to 6 months
• July 14, 2021

For Dupuytren's contracture "Had left hand done in May and now having right hand manipulated tomorrow. Xiaflex injections are somewhat painful but worth it. The local injections are worse but tolerable, manipulation is nothing. Had minor bruising but no problems otherwise. My right hand has swollen and been a little more painful since the Xiaflex injection earlier, but I am right-handed and use it more. Find a good doctor and get this done, nothing to it!"