Alprostadil and Pain: What Users Say

• Iri...
• Taken for 1 to 6 months
• January 21, 2013

Alprostadil for Erectile Dysfunction "Tried this as an alternative to phosphodiesterase inhibitors (Levitra and such) just because I get some side effects from these and wanted to see if I got better results with fewer side effects. Slightly awkward application, sticking a plastic stick down, though I rather like the sensation. Have to say it works REALLY well for me, a bit of penile pain in the area where the pellet is deposited in the urethra, but really quick onset of erection (no need for stimulation at all) and a really firm erection. 500mcg dose is good for me. Also keeps me hard for a good while after climax, so feel ready to go again after a bit of a breather!"

• kan...
• Taken for less than 1 month
• April 27, 2019

Alprostadil for Erectile Dysfunction "After hit or miss experiences with Viagra, I tried 250 mg Muse and the results are stunning. 5 minutes and notice immediate effects... 10 minutes later about 80% erect with zero stimulation. After 20 minutes, ready to go. I did notice slight pain (not to the uncomfortable stage) with erection but at 66 years old, it works like nothing else and after ejaculation, about 50% erect and with modest stimulation from partner, good to go. Takes about 90 to 120 minutes before wearing off. Works with no Viagra-like effects (headache), works while drinking. It's a 10 with me."

• Anonymous
• Taken for 1 to 6 months
• November 4, 2012

Alprostadil for Erectile Dysfunction "After having my prostate removed, I could not get an erection. Viagra and Cialis did not work. The next step was injections, which the doctor recommended Edex. The injection was painless, and I had a great erection. I had an erection for 6 hours, which I have to tell you, it is not a pleasure, but after reducing the dose in half, it's much better. I highly recommend Edex. The doctor gave me an Edex card, which took care of the co-pay and ended up costing me nothing."

• hap...
• Taken for less than 1 month
• August 24, 2012

Alprostadil for Erectile Dysfunction "Used Edex for the first time today. I'm 52. I have low testosterone (350), but no other chronic health issues. My erectile dysfunction is mostly psychological. Doctor gave me a few 20mcg samples. Decided to use a very small dose (about 0.25ml or about 5mcg) since it was my first use. Had a nice hard erection in about 3 minutes, and it lasted about 60 mins. Needle insertion was painless. Small bruise at the insertion site. No pain at all, until about 45 minutes into my erection when I started to have a dull pain in the shaft of my penis. I assume that was due to being erect for 60 mins for the first time in 20 years. Edex was easy to use, worked great for me. Try it !"

• Fir...
• Taken for 1 to 6 months
• January 19, 2016

Alprostadil for Erectile Dysfunction "Worked fantastically. I have tried Caverject since and it worked ok but had a semi that lasted about 3 hours and the injection site was painful. I've also tried the new Vitaros but found it useless. MUSE though... the erection drug of the gods!"

• Auz...
• Taken for less than 1 month
• November 10, 2014

Alprostadil for Erectile Dysfunction "Wow... Had prostate cancer and it was removed 13 months ago. Was still waiting for my erections to start but nothing. My doctor prescribed Viagra as well as using a pump. Viagra helped in getting the erection up, but it would never stay. It would just, as one would say, peter out in a minute. I was also prescribed some suppository things, but the cost was out of this world. So next, he had me try this Edex. Wow, it works like all the above good ratings. Erection was up in under 10 minutes and lasted about 3 hours (great, huh)... only problem was the pain. I was given the lowest amount... Guess it's not for me. 10 was because it works, a 3 because of the pain."

• Lav...
• Taken for 2 to 5 years
• January 21, 2021

Alprostadil for Erectile Dysfunction "After trying Silendafil and Cialis after prostate surgery, neither worked for me. Using the Caverject injection was good, but not a big fan of the needle. Using the 500 Muse was great for me. Little pain during insertion, but got a really good hard-on. I will continue to use it if effective, if not, surgery for me. I do recommend this product if your insurance pays for it. Mine is free with the Veterans Administration."

• Anonymous
• February 28, 2014

Alprostadil for Erectile Dysfunction "I have been using Edex for 2 or 3 years. At first, there was very little pain, but now the pain approaches severe. I am using the maximum dosage, and I do get an erection, but sometimes my erection peters out (pun intended), and also it has become more difficult to achieve an orgasm. I also use MUSE sometimes, and although it is not as effective as Edex, it damn sure does not hurt as much as Edex. I am 74 yrs. YOUNG!"

• SEM...
• Taken for 10 years or more
• July 14, 2017

Alprostadil for Erectile Dysfunction "I am not your typical user! Did Muse at least 50 times. This I know. Every erection is always different, but ALWAYS BETTER for that day with Muse. Sure, there might be pain in your penis, but look at the color of it. Bright purple, right? That's because there is more blood in there than even in your youth! Did 5 minutes a day on an elliptical machine, reaching 15 minutes after a month. Did a Muse 1000 mcg and had a 4-hour porn star performance. Could have hit it with a board, only an ice-cold shower brought it down!"

• laz...
• Taken for less than 1 month
• December 23, 2013

Alprostadil for Erectile Dysfunction "Tried it once by itself, very slight results after three minutes that lasted only about five minutes, and caused a lot of penile pain that lasted over an hour. Tried a second time after taking Cialis first, as suggested by the urologist, and it was even less effective with very slight results that lasted less than five minutes."

• Lov...
• July 15, 2014

For Erectile Dysfunction "I have used 20 injections of alprostadil. The erections have been better than I expected. Most of the time my erection has lasted for 2 to 3 hours, and I have been perfectly satisfied and happy with the results. A few times I had some pain, but I have decreased the dose, and it works fine now. I don't like to inject my penis, but I must say the gain is worth the pain."

• Cav...
• Taken for less than 1 month
• February 2, 2017

Alprostadil for Erectile Dysfunction "I had my prostate removed 13 months ago and was advised by my urologist and prostate nurse to commence a rehab program of 5 mg Cialis daily and include a pump routine (I do 6 x 5 minutes, one to two daily), which has almost returned my length and girth to square one. As I hadn't been achieving an erection adequate for penetration, my urologist instructed me on injecting Caverject Impulse 10 mcg last Friday with great results. On Monday at home, I self-injected 10 mcg with no pain and stayed erect for 1 1/2 hours. Although I didn't hit any small veins, it was a bit awkward finding the best spot, so this morning I decided to do a gentle pump, increasing the penis size, and injected very easily. Increasing my dose to 15 mcg was a bit tight."

• Geo...
• Taken for 1 to 2 years
• December 12, 2019

Alprostadil for Erectile Dysfunction "I have been using Edex for 20 months after a Da Vinci prostatectomy. Works perfectly. Started with a dose of about 7, 2 months after the operation but found it to be not enough, and so my Doc gave me the 20 mg syringes. Tried 15, and that worked fine for a while before becoming painful, particularly during penetration. Dose reduction helped matters, and today, 20 months later, 5 gives the same results, presumably because nerve endings have healed and linked since the operation. A great drug that for me only wears off after 4 hours, which is a bit problematic when my wife wants some action in the morning. Only 2 misfires, both times when injecting standing up. Lying down, I find easier and more comfortable. If the drug usage is painful, it is probably because you are overdosing - anyway, that is my experience."

• Got...
• Taken for less than 1 month
• November 18, 2016

For Erectile Dysfunction "Unbelievable. I tried through my primary physician, Viagra, Cialis, and with a pump. Nothing was worth the end disappointment. Squeezing and pumping wasn't working. My physician referred me to a urologist, and after a consult, he told me he had a med that would most likely pick me up (no pun intended). The injection was amazing. He performed a test injection, very small needle, little pain, 5 minutes later, I was blessing him like Jesus. I hadn't had an erection like that since my 20s. Don't hesitate, a new chapter in your life is awaiting. I promise. S.W. Fairhope, AL."

• Jac...
• July 27, 2017

Alprostadil for Erectile Dysfunction "I have tried just about every erectile dysfunction remedy available over the last few years, none of which did much for me. My erections just were not strong enough to facilitate good sex for myself nor my wife, and I was losing any sensation. My urologist suggested I try MUSE, and I did. But only a couple of times. The feeling I got was like being kicked in the groin. I thought the first time was possibly only a fluke for some reason, but I was WRONG! The second time was just as bad! I have NEVER felt anything like the aching and discomfort I experienced, possibly outside of being kicked in the groin. And my erection was just as weak as ever, and my penis was so painful sex would have been impossible anyway. You can HAVE this stuff."

• Bug...
• Taken for less than 1 month
• January 26, 2017

Alprostadil for Erectile Dysfunction "At my urologist's suggestion, I used Edex today. 10 mg dose and injected the entire tube. I had a solid erection in about 5 minutes, and it lasted for 3 hours. It went up much faster than it went down. So, it worked. Unfortunately, it became quite painful, so much so that intercourse would not have been pleasurable. Dosage can vary from 1-40 mg, so I will try again with a 2 or 3 mg dose. I had my prostate removed 2 years ago and haven't had a woody until today. I'm wondering if the pain is from the stretching of the tissues. Some indication online that there is less pain with increased use. Viagra and Cialis did not work, and I had crazy muscle pain with the latter. So this is my likely last option."

• VA ...
• Taken for 2 to 5 years
• April 25, 2017

Alprostadil for Erectile Dysfunction "After fighting rectal cancer for 2 years, I lost the ability to get hard. My doctor prescribed 100 mg Viagra, which worked for a while, and then it got harder to produce an erection. The doctor asked me if I thought I could stick a small needle into my penis. I told him I could and would if it would help me get an erection. I have been using Edex for over 2 years with mostly a good reaction to the drug. The only reason I gave it a rating of 9 instead of a 10 was that every once in a while, when sticking the needle in, I would miss the sweet spot on my penis, and my erection wouldn't happen or only last a short amount of time. I'm finding after 2 years of using Edex, the needle has become harder to inject and more painful. My wife loves the hardness."

• rh7...
• Taken for 1 to 2 years
• March 21, 2017

Alprostadil for Erectile Dysfunction "Creates only a soft erection; not enough for intercourse. I have mentally separated ejaculation from intercourse because what I primarily want is the sense of 'oneness' with my mate. With a MUSE injection, I feel a sort of pain, which also is felt in my ankles and lower legs. It's pretty useless for me. Does give a soft erection for a short time."

• 124...
• Taken for less than 1 month
• April 8, 2014

For Erectile Dysfunction "Tried 3 times with 40 mcg dose, once in doctor's office. Absolutely NO results, but really big pain and discomfort. Have lower back pain, testicular pain, injection site pain, and overall serious discomfort. Have to take oral pain medication to relieve the seriousness of the pain, and will not use this. Will re-visit my urologist again and let him know the torture this is causing, and I have a very high pain threshold."

• 124...
• Taken for less than 1 month
• April 8, 2014

For Erectile Dysfunction "Tried 3 times with 40 mcg dose, once in doctor's office. Absolutely NO results, but really big pain and discomfort. Have lower back pain, testicular pain, injection site pain, and overall serious discomfort. Have to take oral pain medication to relieve the seriousness of the pain, and will not use this. Will re-visit my urologist again and let him know the torture this is causing, and I have a very high pain threshold."

• Got...
• January 1, 2017

For Erectile Dysfunction "Now been using for 2 months, 24 injections into treatment. I've found that if not careful with the injection site, it can cause pain for up to an hour and a less than satisfactory result. HOWEVER, pay close attention and inject as instructed. If not deep enough, it can be painful and cause bruising. I found that 3 o'clock and 9 o'clock and close to the base of the penis works flawlessly. I still praise this med. Works great!"

• ext...
• Taken for 2 to 5 years
• November 11, 2015

For Erectile Dysfunction "My partner used the drug, after which I experienced side effects of extreme burning sensation, irritation, redness. It felt like cuts, but it was due to the side effects of other medication when injected into the male. The medication mixes with sperm he ejaculated into the woman. It burns and irritates the woman inside and outside, it’s extremely painful and causes damage to the vaginal area. Has the company started doing research into something that would neutralize that particular side effect that the partners may encounter? Because it's extremely painful to the vaginal area."

• Wee...
• July 9, 2016

For Erectile Dysfunction "First couple of times took 20 mg and worked great. It lasted about five hours without any side effects. Dropped down to 10 mg, and the last two experiences were terrible, had an erection for seven hours without going down, after sex, it was extremely painful and wouldn't go down."

• Tho...
• Taken for less than 1 month
• December 13, 2019

Alprostadil for Erectile Dysfunction "I've used Edex three times now and have had mixed results. I think my dose is not enough, I currently take 20 mcg. I probably need to take more. The injections work, but I need to have my dose adjusted by the doctor. There is penile pain after the shot for a couple of hours, but not enough to get me to stop using it."

• Bil...
• Taken for 2 to 5 years
• November 11, 2023

Alprostadil for Erectile Dysfunction "Started with the dual chamber 20 mcg Caverject injections. Injected two amounts, i.e., 40 mcg in total. Mixed results. Partial erection. Due to lack of manufacturing supply, swapped to the single 40 mcg single injection type. Used the same dose as before, but no erection at all, just pain. Tried multiple times, but no change. Pain is sometimes less, but can't deduce why. Different injection methods, ensuring temperature of liquid is room temp, give no change in results. I am medically qualified."