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Alprostadil Dosage

Medically reviewed by Drugs.com. Last updated on Jul 24, 2023.

Applies to the following strengths: 0.5 mg/mL; 20 mcg; 10 mcg; 5 mcg; 20 mcg/mL; 10 mcg/mL; 40 mcg; 125 mcg; 250 mcg; 500 mcg; 1000 mcg

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Erectile Dysfunction

INTRACAVERNOUS:
1 to 40 mcg intracavernous injection into the lateral penis given over 5 to 10 seconds

Maximum dose: 3 times per week, with at least 24 hours between each use

Comments:


TRANSURETHRAL:
Initial dose: 125 or 250 mcg inserted into the urethra
Maximum dose: 2 systems per 24-hour period

Comments:

Usual Pediatric Dose for Patent Ductus Arteriosus

Less than 12 Months:
Initial dose: 0.05 to 0.1 mcg/kg/min continuous IV infusion
Maintenance dose: 0.01 to 0.4 mcg/kg/min continuous IV infusion

Comments:


Use: Palliative, not definitive, therapy to temporarily maintain ductus arteriosus patency until corrective or palliative surgery can be performed in neonates with congenital heart defects who depend upon the patent ductus for survival. Such congenital heart defects include pulmonary atresia, pulmonary stenosis, tricuspid atresia, tetralogy of Fallot, aortic arch interruption, aorta coarctation, or transposition of the great vessels with or without other defects.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

US BOXED WARNING:


Safety and efficacy have not been established in patients 1 year to less than 18 years for the IV formulation.
Safety and efficacy have not been established in patients younger than 18 years for the intracavernous and transurethral formulations.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice: Refer to manufacturer product information.

Storage requirements:


Reconstitution/preparation techniques: Refer to manufacturer product information.

General:

Monitoring:

Patient advice:
Intracavernous:

Intracavernous and Transurethral:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.