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Prostate Biopsy


What you need to know about a prostate biopsy:

A prostate biopsy is a procedure to remove samples of tissue from your prostate gland. The prostate is a male sex gland that makes fluid found in semen. It is located just below the bladder. After the samples are removed, they are sent to a lab and tested for cancer.

How to prepare for a prostate biopsy:

  • Your healthcare provider will talk to you about how to prepare for this procedure. He may tell you not to eat or drink anything after midnight on the day of your surgery. You will need to stop taking blood thinners several days before your procedure. Examples of blood thinners include warfarin and NSAIDs. You may also need to stop taking herbal supplements before your procedure. Your healthcare provider will tell you what other medicines to take or not take on the day of your procedure.
  • You will be given an antibiotic to help prevent a bacterial infection. You may need to give yourself an enema (liquid medicine put in your rectum) to help empty your bowel before your procedure.

What will happen during a prostate biopsy:

  • You may need to lie on your side with your knees pulled up toward your chest. Numbing cream or gel may be put into your rectum, or numbing medicine may be injected near your prostate. You may instead be given general anesthesia to keep you asleep and free from pain during the procedure. A biopsy sample may be taken through your rectum, urethra, or perineum. The perineum is the area between your scrotum and rectum. Most of the time, biopsy samples are taken through the rectum.
  • If your healthcare provider takes a sample through your rectum, he will insert a small ultrasound probe into your rectum. The ultrasound shows pictures of your prostate on a monitor, and is used to help guide the biopsy needle. Your healthcare provider will push the biopsy needle through the wall of your rectum and into your prostate gland. Your healthcare provider will remove between 6 to 12 samples of tissue from different areas of your prostate gland. The samples will be sent to a lab and tested for cancer.

What will happen after a prostate biopsy:

You may feel soreness at the biopsy site. You may need to take antibiotics for up to 2 days after your procedure to help prevent an infection. You may have some bleeding from your rectum. You may also have blood in your urine, bowel movements, or semen.

Risks of a prostate biopsy:

You may bleed more than expected or get an infection in your urinary tract or prostate gland. The infection may spread to your blood and the rest of your body. Your bladder may not empty completely when you urinate. You may need a catheter to help empty your bladder for a short period of time. Cancer cells may be missed during your biopsy procedure. You may need another prostate biopsy to check for cancer again.

Seek care immediately if:

  • You have heavy bleeding from your rectum.
  • You urinate very little or not at all.
  • You have pain from your procedure that gets worse, even after you take pain medicine.

Contact your healthcare provider if:

  • You have a fever or chills.
  • You feel pain or burning when you urinate.
  • Your urine is cloudy or smells bad.
  • You have questions or concerns about your condition or care.


  • Medicines can help decrease pain. You may need medicine to prevent or treat a bacterial infection. Ask how to take pain medicine safely.
  • Take your medicine as directed. Call your healthcare provider if you think your medicine is not helping or if you have side effects. Tell him if you are allergic to any medicine. Keep a list of the medicines, vitamins, and herbs you take. Include the amounts, and when and why you take them. Bring the list or the pill bottles to follow-up visits. Carry your medicine list with you in case of an emergency.

Follow up with your healthcare provider or urologist as directed:

You may need to return for more tests or procedures. Write down your questions so you remember to ask them during your visits.

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The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.