Medically reviewed on May 2, 2018.
- This medicine is used with a drug called rituximab. Talk with the doctor about the risks and side effects that may happen.
- This medicine may have unsafe effects on the bone marrow. The bone marrow may not be able to make cells found in the blood as well as it used to.
- A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems that may not go away, and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.
Uses of Zevalin Y-90:
- It is used to treat lymphoma.
What do I need to tell my doctor BEFORE I take Zevalin Y-90?
- If you have an allergy to ibritumomab, rituximab, or any other part of Zevalin Y-90 (ibritumomab tiuxetan).
- If you are allergic to mouse proteins or yttrium chloride, talk with the doctor.
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- If you are taking any drugs that may raise the chance of bleeding. There are many drugs that can do this. Ask your doctor or pharmacist if you are not sure.
- If you are breast-feeding or plan to breast-feed.
This is not a list of all drugs or health problems that interact with Zevalin Y-90 (ibritumomab tiuxetan).
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Zevalin Y-90 (ibritumomab tiuxetan) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Zevalin Y-90?
- Tell all of your health care providers that you take Zevalin Y-90 (ibritumomab tiuxetan). This includes your doctors, nurses, pharmacists, and dentists.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
- You may have more chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu.
- Talk with your doctor before getting any vaccines while you take Zevalin Y-90 (ibritumomab tiuxetan) and after you stop taking it. Vaccine use with Zevalin Y-90 (ibritumomab tiuxetan) may either raise the chance of an infection or make the vaccine not work as well. Talk with your doctor.
- This medicine is radioactive. You will need to follow what the doctor has told you to lessen being exposed to Zevalin Y-90 (ibritumomab tiuxetan). Talk with the doctor.
- If you have upset stomach, throwing up, loose stools (diarrhea), or are not hungry, talk with your doctor. There may be ways to lower these side effects.
- A bone marrow problem called myelodysplastic syndrome (MDS) and a type of leukemia have rarely happened in patients treated with Zevalin Y-90 (ibritumomab tiuxetan). Sometimes, this has been deadly. Talk with your doctor.
- This medicine may cause harm to the unborn baby if you take it while you are pregnant.
- Use birth control that you can trust during care and for 12 months after care ends.
- If you get pregnant while taking Zevalin Y-90 (ibritumomab tiuxetan) or within 12 months after your last dose, call your doctor right away.
How is this medicine (Zevalin Y-90) best taken?
Use Zevalin Y-90 (ibritumomab tiuxetan) as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- This medicine is given as a shot into a vein.
What do I do if I miss a dose?
- Call your doctor to find out what to do.
See also: Dosage Information (in more detail)
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
- Signs of a urinary tract infection (UTI) like blood in the urine, burning or pain when passing urine, feeling the need to pass urine often or right away, fever, lower stomach pain, or pelvic pain.
- Signs of bleeding like throwing up blood or throw up that looks like coffee grounds; coughing up blood; blood in the urine; black, red, or tarry stools; bleeding from the gums; vaginal bleeding that is not normal; bruises without a reason or that get bigger; or any bleeding that is very bad or that you cannot stop.
- Signs of high blood pressure like very bad headache or dizziness, passing out, or change in eyesight.
- Pale skin.
- Pinpoint red spots on the skin.
- Feeling very tired or weak.
- Pain and irritation where Zevalin Y-90 (ibritumomab tiuxetan) goes into the body.
- This medicine may cause tissue damage if the drug leaks from the vein. Tell your nurse if you have any redness, burning, pain, swelling, blisters, skin sores, or leaking of fluid where the drug is going into your body.
What are some other side effects of Zevalin Y-90?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Feeling tired or weak.
- Nose and throat irritation.
- Loose stools (diarrhea).
- Upset stomach.
- Belly pain.
- Muscle pain.
- Not hungry.
- Night sweats.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
See also: Side effects (in more detail)
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Zevalin Y-90?
- If you need to store Zevalin Y-90 (ibritumomab tiuxetan) at home, talk with your doctor, nurse, or pharmacist about how to store it.
Consumer information use
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
- Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
- Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about Zevalin Y-90 (ibritumomab tiuxetan), please talk with your doctor, nurse, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
More about Y-90 Zevalin (ibritumomab)
- Y-90 Zevalin Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Support Group
- Pricing & Coupons
- En Español
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- Drug class: CD20 monoclonal antibodies