Skip to Content

Tiludronate

Generic Name: tiludronate (TYE-loo-DROE-nate)
Brand Name: Skelid

Tiludronate is used for:

Treating adults with Paget disease. It may also be used for other conditions as determined by your doctor.

Tiludronate is a bisphosphonate. It works by slowing the resorption of bone and allowing new bone to be formed.

Do NOT use tiludronate if:

  • you are allergic to any ingredient in tiludronate
  • you have severe kidney problems
  • you are unable to stand or sit for at least 30 minutes

Contact your doctor or health care provider right away if any of these apply to you.

Before using tiludronate:

Some medical conditions may interact with tiludronate. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have esophagus problems (eg, Barrett esophagus, narrow or blocked esophagus), trouble swallowing, pain or burning with swallowing, or stomach or intestinal problems (eg, ulcers, inflammation)
  • if you have a history of kidney problems, asthma, heartburn, chest pain, or low blood calcium levels

Some MEDICINES MAY INTERACT with tiludronate. However, no specific interactions with tiludronate are known at this time.

Ask your health care provider if tiludronate may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use tiludronate:

Use tiludronate as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Tiludronate is effective only if taken on an empty stomach. Do not take tiludronate within 2 hours of eating or drinking.
  • Take tiludronate by mouth with a full glass of water (6 to 8 oz/180 to 240 mL). Do not lie down for at least 30 minutes after you take tiludronate.
  • If you are also taking calcium or iron supplements, vitamins, antacids containing calcium, aspirin, or indomethacin, they may interfere with the absorption of tiludronate. Do not take tiludronate within 2 hours of these medicines.
  • If you are also taking an antacid that has aluminum or magnesium in it, take it at least 2 hours after you take tiludronate.
  • Continue to take tiludronate even if you feel well. Do not miss any doses.
  • If you miss a dose of tiludronate, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses on the same day.

Ask your health care provider any questions you may have about how to use tiludronate.

Important safety information:

  • Tiludronate may cause drowsiness. This effect may be worse if you take it with alcohol or certain medicines. Use tiludronate with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
  • Do not drink alcohol, smoke, or use other tobacco products while taking tiludronate.
  • It is important to have enough calcium and vitamin D in your diet. Ask your doctor or pharmacist if you have questions about your diet or about taking dietary supplements such as calcium or vitamin D.
  • Talk to your doctor about weight-bearing exercises to increase the calcium density of your bones.
  • Tiludronate may cause jaw bone problems in some patients. Your risk may be greater the longer you take tiludronate or if you have cancer, poor dental hygiene, or certain other conditions (eg, anemia, blood clotting problems, infections, dental problems). Your risk may also be greater if you use certain medicines or therapies (eg, chemotherapy, corticosteroids, radiation). Talk to your doctor about having a dental exam before you start to use tiludronate. Ask your doctor any questions you may have about dental treatment while you use tiludronate.
  • Tell your doctor or dentist that you take tiludronate before you receive any medical or dental care, emergency care, or surgery.
  • Worsening of asthma has been reported in patients taking medicines like this one. Discuss any questions or concerns with your doctor.
  • Lab tests, including calcium levels, may be performed while you use tiludronate. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Tiludronate should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using tiludronate while you are pregnant. It is not known if this medicine is found in breast milk. If you are or will be breast-feeding while you use tiludronate, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of tiludronate:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Abnormal skin sensations; diarrhea; gas; nausea; stomach upset; stuffy nose; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black or bloody stools; chest pain; difficulty swallowing; new, worsening, or severe heartburn; pain when swallowing; red, swollen, blistered, or peeling skin; severe bone, muscle, or joint pain; severe or persistent stomach pain; swelling of the hands or feet; swelling or pain in the jaw; throat pain or irritation; vision changes; vomit that looks like coffee grounds.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Do not lie down. Symptoms may include heartburn; pain upon swallowing; stomach upset or pain; ulcers.

Proper storage of tiludronate:

Store tiludronate at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep tiludronate out of the reach of children and away from pets.

General information:

  • If you have any questions about tiludronate, please talk with your doctor, pharmacist, or other health care provider.
  • Tiludronate is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take tiludronate or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about tiludronate. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to tiludronate. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using tiludronate.

Review Date: August 8, 2016

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

Hide