Generic Name: pramipexole (PRAM-i-PEX-ole)
Brand Name: Mirapex
Pramipexole is used for:
Treating the signs and symptoms of Parkinson disease. It is also used to treat restless legs syndrome (RLS). It may also be used for other conditions as determined by your doctor.
Pramipexole is a dopamine agonist. Exactly how pramipexole works is not known. It may increase the action of certain chemical receptors in the brain.
Do NOT use pramipexole if:
- you are allergic to any ingredient in pramipexole
- you are taking another medicine that has pramipexole in it
Contact your doctor or health care provider right away if any of these apply to you.
Before using pramipexole:
Some medical conditions may interact with pramipexole. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have kidney problems; low blood pressure; dizziness or fainting when you sit or stand up; sleep problems (eg, daytime sleepiness); trouble controlling your muscles; or mental, mood, or behavior problems
- if you drink alcohol or have a history of compulsive behavior (eg, eating, gambling, shopping)
Some MEDICINES MAY INTERACT with pramipexole. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Cimetidine because it may increase the risk of pramipexole's side effects
- Butyrophenones (eg, haloperidol), metoclopramide, phenothiazines (eg, chlorpromazine), or thioxanthenes (eg, thiothixene) because they may decrease pramipexole's effectiveness
- Levodopa because the risk of its side effects may be increased by pramipexole
This may not be a complete list of all interactions that may occur. Ask your health care provider if pramipexole may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use pramipexole:
Use pramipexole as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- An extra patient leaflet is available with pramipexole. Talk to your pharmacist if you have questions about this information.
- Take pramipexole by mouth with or without food. If nausea occurs, take with food to reduce nausea.
- If you are taking pramipexole for RLS, you should take pramipexole 2 to 3 hours before bedtime, unless your doctor tells you otherwise.
- Your dose will be started low and gradually increased to achieve the best results. Do not change your dose sooner than recommended.
- Do not suddenly stop taking pramipexole without checking with your doctor. Severe side effects, including fever, confusion, and stiff muscles, may occur. If you need to stop pramipexole, your doctor will gradually lower your dose.
- If you miss a dose of pramipexole, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. If you miss several doses, contact your doctor before you start to take pramipexole again.
Ask your health care provider any questions you may have about how to use pramipexole.
Important safety information:
- Tell your doctor or dentist that you take pramipexole before you receive any medical or dental care, emergency care, or surgery.
- Pramipexole may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use pramipexole with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Do not drink alcohol while you are using pramipexole.
- Check with your doctor before you use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using pramipexole; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
- Pramipexole may cause dizziness, light-headedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
- Some patients who take pramipexole have reported suddenly falling asleep while performing daily activities (eg, driving, eating, talking). Some patients did not experience drowsiness and felt that they were alert immediately before suddenly falling asleep. Some of these events have been reported as late as 1 year after pramipexole was started. Use caution when driving, operating machinery, or performing other activities that could be dangerous. Inform your doctor if you experience unusual drowsiness or sleepiness while using pramipexole.
- Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
- In patients with RLS, pramipexole may cause a worsening of RLS symptoms or cause symptoms to occur earlier in the day (afternoon or evening) or spread to other extremities. Discuss any questions or concerns with your doctor.
- Some people have experienced new, unusual, or increased urges (eg, gambling, sexual urges) while using pramipexole. Tell your doctor right away if you or a caregiver notice such effects.
- Patients with Parkinson disease may have an increased risk of developing a certain type of skin cancer (melanoma). It is not known if pramipexole also increases the risk of melanoma. You may need to have skin exams while you are using pramipexole. Discuss any questions or concerns with your doctor.
- Lab tests, including blood pressure or skin checks, may be performed while you use pramipexole. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Use pramipexole with caution in the ELDERLY; they may be more sensitive to its effects.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using pramipexole while you are pregnant. It is not known if this medicine is found in breast milk. Do not breast-feed while taking pramipexole.
Possible side effects of pramipexole:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Abnormal dreams; constipation; diarrhea; dizziness; drowsiness; dry mouth; headache; loss of appetite; nausea; stuffy nose; tiredness; trouble sleeping; weakness.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal thinking; balance problems; change in the amount of urine produced; chest pain; confusion; dark urine; decreased sexual ability; difficulty walking; fainting; hallucinations; memory problems; muscle pain, tenderness, or weakness; new or unusual skin growths or change in the appearance of a mole; new or worsening mental, mood, or behavior changes (eg, aggression, agitation, paranoia); severe or persistent dizziness, drowsiness, or sleepiness; shortness of breath; sudden irresistible urge to sleep or suddenly falling asleep at unusual times; sudden, unexplained weight gain; swelling of the hands, ankles, legs, or feet; trouble swallowing; unusual or intense urges (eg, gambling, sexual urges); unusual twitching or muscle movements; vision changes.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.Proper storage of pramipexole:
Store pramipexole at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep pramipexole out of the reach of children and away from pets.
- If you have any questions about pramipexole, please talk with your doctor, pharmacist, or other health care provider.
- Pramipexole is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take pramipexole or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about pramipexole. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to pramipexole. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using pramipexole.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
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