Oxycodone and Aspirin

Generic name: Oxycodone and Aspirin [ oks-i-KOE-done-& AS-pir-in ]
Drug class: Narcotic analgesic combinations

Medically reviewed by Drugs.com. Last updated on Dec 9, 2023.

Uses of Oxycodone and Aspirin:

• It is used to ease pain.

What do I need to tell my doctor BEFORE I take Oxycodone and Aspirin?

For all patients taking oxycodone and aspirin:

• If you have an allergy to aspirin or NSAIDs.
• If you have gotten nasal polyps or had swelling of the mouth, face, lips, tongue, or throat; unusual hoarseness; or trouble breathing with aspirin or NSAID use.
• If you are allergic to oxycodone and aspirin; any part of oxycodone and aspirin; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
• If you have any of these health problems: Lung or breathing problems like asthma, trouble breathing, or sleep apnea; high levels of carbon dioxide in the blood; or stomach or bowel block or narrowing.
• If you have any of these health problems: Hemophilia or ulcer disease.
• If you have any of these health problems: Kidney disease or liver disease.
• If you have Reye's syndrome.
• If you are taking any of these drugs: Buprenorphine, butorphanol, nalbuphine, or pentazocine.
• If you have taken certain drugs for depression or Parkinson's disease in the last 14 days. This includes isocarboxazid, phenelzine, tranylcypromine, selegiline, or rasagiline. Very high blood pressure may happen.
• If you are taking any of these drugs: Linezolid or methylene blue.
• If you are taking any other NSAID.
• If you are pregnant or may be pregnant. Do not take oxycodone and aspirin if you are in the third trimester of pregnancy. You may also need to avoid oxycodone and aspirin at other times during pregnancy. Talk with your doctor to see when you need to avoid taking oxycodone and aspirin during pregnancy.
• If you are breast-feeding. Do not breast-feed while you take oxycodone and aspirin.

Children:

• If your child has or is getting better from flu signs, chickenpox, or other viral infections.

This is not a list of all drugs or health problems that interact with oxycodone and aspirin.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take oxycodone and aspirin with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Oxycodone and Aspirin?

• Tell all of your health care providers that you take oxycodone and aspirin. This includes your doctors, nurses, pharmacists, and dentists.
• Avoid driving and doing other tasks or actions that call for you to be alert until you see how oxycodone and aspirin affects you.
• To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down. Be careful going up and down stairs.
• You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
• Call your doctor right away if you have any signs of bleeding problems, like bruising; black, tarry, or bloody stools; bleeding gums; blood in the urine; coughing up blood; cuts that take a long time to stop bleeding; feel dizzy; feeling very tired or weak; nosebleeds; pain or swelling; throwing up blood or throw up that looks like coffee grounds; or very bad headache.
• If you are taking aspirin to help prevent a heart attack, talk with your doctor.
• This medicine may affect certain lab tests. Tell all of your health care providers and lab workers that you take oxycodone and aspirin.
• Long-term use of an opioid drug may lead to lower sex hormone levels. Call your doctor if you have a lowered interest in sex, fertility problems, no menstrual period (women), or change in sex ability (men).
• This medicine may raise the chance of seizures in some people, including people who have had seizures in the past. Talk to your doctor to see if you have a greater chance of seizures while taking oxycodone and aspirin.
• Very bad stomach ulcers or bleeding can happen with oxycodone and aspirin. Taking it in high doses or for a long time, smoking, or drinking alcohol raises the chance of these side effects. Taking oxycodone and aspirin with food will not lower the chance of these effects. Call your doctor or get medical help right away if you get very bad stomach or back pain; black, tarry, or bloody stools; throwing up blood or throw up that looks like coffee grounds; or weight gain or swelling that is not normal.
• Taking an opioid drug like oxycodone and aspirin may lead to a rare but very bad adrenal gland problem. Call your doctor right away if you have very bad dizziness or passing out, very bad upset stomach or throwing up, or if you feel less hungry, very tired, or very weak.
• If you are 65 or older, use oxycodone and aspirin with care. You could have more side effects.
• Do not give to children and teenagers who have or are getting better from flu signs, chickenpox, or other viral infections due to the chance of Reye's syndrome. Reye's syndrome causes very bad problems to the brain and liver.
• This medicine may cause harm to the unborn baby if you take it while you are pregnant. If you are pregnant or you get pregnant while taking oxycodone and aspirin, call your doctor right away.

How is this medicine (Oxycodone and Aspirin) best taken?

Use oxycodone and aspirin as ordered by your doctor. Read all information given to you. Follow all instructions closely.

• Take with or without food. Take with food if it causes an upset stomach.
• Do not take oxycodone and aspirin with other strong pain drugs or if you are using a pain patch without talking to your doctor first.
• If you have been taking oxycodone and aspirin for a long time or at high doses, it may not work as well and you may need higher doses to get the same effect. This is known as tolerance. Call your doctor if oxycodone and aspirin stops working well. Do not take more than ordered.
• Long-term or regular use of opioid drugs like oxycodone and aspirin may lead to dependence. Lowering the dose or stopping oxycodone and aspirin all of a sudden may cause a greater risk of withdrawal or other severe problems. Talk to your doctor before you lower the dose or stop oxycodone and aspirin. You will need to follow your doctor’s instructions. Tell your doctor if you have more pain, mood changes, thoughts of suicide, or any other bad effects.

What do I do if I miss a dose?

• If you take oxycodone and aspirin on a regular basis, take a missed dose as soon as you think about it.
• If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
• Do not take 2 doses at the same time or extra doses.
• Many times oxycodone and aspirin is taken on an as needed basis. Do not take more often than told by the doctor.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
• Signs of high potassium levels like a heartbeat that does not feel normal; feeling confused; feeling weak, lightheaded, or dizzy; feeling like passing out; numbness or tingling; or shortness of breath.
• Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight.
• Very bad dizziness or passing out.
• Severe constipation or stomach pain. These may be signs of a severe bowel problem.
• Noisy breathing.
• Ringing in ears.
• Hearing loss.
• Dark urine or yellow skin or eyes.
• Not able to pass urine or change in how much urine is passed.
• Mood changes.
• Seizures.
• Chest pain or pressure or a fast heartbeat.
• Feeling confused.
• A severe and sometimes deadly problem called serotonin syndrome may happen if you take oxycodone and aspirin with certain other drugs. Call your doctor right away if you have agitation; change in balance; confusion; hallucinations; fever; fast or abnormal heartbeat; flushing; muscle twitching or stiffness; seizures; shivering or shaking; sweating a lot; severe diarrhea, upset stomach, or throwing up; or severe headache.

Related/similar drugs

acetaminophen, tramadol, cyclobenzaprine, naproxen, oxycodone, Tylenol

What are some other side effects of Oxycodone and Aspirin?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

• Constipation.
• Feeling dizzy, sleepy, tired, or weak.
• Upset stomach or throwing up.
• Headache.
• Stomach pain.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Oxycodone and Aspirin?

• Store at room temperature.
• Store in a dry place. Do not store in a bathroom.
• Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
• Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer Information Use and Disclaimer

• If your symptoms or health problems do not get better or if they become worse, call your doctor.
• Do not share your drugs with others and do not take anyone else's drugs.
• This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time oxycodone and aspirin is refilled. If you have any questions about oxycodone and aspirin, please talk with the doctor, pharmacist, or other health care provider.
• If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer