Generic Name: Irinotecan (Liposomal) (eye rye no TEE kan lye po SO mal)
Brand Name: Onivyde
Medically reviewed on Sep 5, 2018
- Low white blood cell counts have happened with drugs like this one. This may lead to a higher chance of getting an infection. Deadly infections have rarely happened. Tell your doctor if you have ever had a low white blood cell count. Call your doctor right away if you have signs of infection like fever, chills, or sore throat. Talk with your doctor.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- Diarrhea can happen with Onivyde (irinotecan (liposomal)). Diarrhea may happen early (within 24 hours) or later (after 24 hours) after getting Onivyde (irinotecan (liposomal)). Most of the time, early diarrhea goes away and is not severe. Early diarrhea may happen with signs like runny nose, flushing, tearing, stomach cramps, more saliva, sweating, or slow heartbeat. Late diarrhea may lead to some health problems like dehydration, infection, or electrolyte problems and can be life-threatening. Talk with your doctor about what to do if you have diarrhea. Call your doctor right away the first time you have diarrhea, if you have very bad diarrhea, or if you are not able to get diarrhea under control within 24 hours. Call your doctor right away if you have black or bloody stools, signs of dehydration, or if you are not able to take fluids by mouth.
- Do not take Onivyde (irinotecan (liposomal)) if you have a bowel block. Talk with your doctor.
Uses of Onivyde:
- It is used to treat pancreatic cancer.
What do I need to tell my doctor BEFORE I take Onivyde?
- If you have an allergy to irinotecan or any other part of Onivyde (irinotecan (liposomal)).
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- If you take any drugs (prescription or OTC, natural products, vitamins) that must not be taken with Onivyde (irinotecan (liposomal)), like certain drugs that are used for HIV, infections, or seizures. There are many drugs that must not be taken with Onivyde (irinotecan (liposomal)).
- If you are taking St. John's wort. Do not take St. John's wort with Onivyde (irinotecan (liposomal)). This medicine may not work as well.
- If you are breast-feeding. Do not breast-feed while you take Onivyde (irinotecan (liposomal)) or for 1 month after you stop Onivyde (irinotecan (liposomal)).
This is not a list of all drugs or health problems that interact with Onivyde (irinotecan (liposomal)).
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Onivyde (irinotecan (liposomal)) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Onivyde?
- Tell all of your health care providers that you take Onivyde (irinotecan (liposomal)). This includes your doctors, nurses, pharmacists, and dentists.
- You may have more chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu.
- You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
- If you have upset stomach, throwing up, loose stools (diarrhea), or are not hungry, talk with your doctor. There may be ways to lower these side effects.
- Talk with your doctor before getting any vaccines. Use with Onivyde (irinotecan (liposomal)) may either raise the chance of an infection or make the vaccine not work as well.
- If you are a man and have sex with a female who could get pregnant, protect her from pregnancy during care and for at least 4 months after stopping Onivyde (irinotecan (liposomal)). Use birth control that you can trust.
- If you are a man and your sex partner gets pregnant while you take Onivyde (irinotecan (liposomal)) or within 4 months after your last dose, call your doctor right away.
- This medicine may cause harm to the unborn baby if you take it while you are pregnant.
- Use birth control that you can trust to prevent pregnancy while taking Onivyde (irinotecan (liposomal)) and for at least 1 month after stopping Onivyde (irinotecan (liposomal)).
- If you get pregnant while taking Onivyde (irinotecan (liposomal)) or within 1 month after your last dose, call your doctor right away.
How is this medicine (Onivyde) best taken?
Use Onivyde (irinotecan (liposomal)) as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- It is given as an infusion into a vein over a period of time.
- Other drugs may be given before Onivyde (irinotecan (liposomal)) to help avoid side effects.
What do I do if I miss a dose?
- Call your doctor to find out what to do.
See also: Dosage Information (in more detail)
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
- Signs of fluid and electrolyte problems like mood changes, confusion, muscle pain or weakness, a heartbeat that does not feel normal, very bad dizziness or passing out, fast heartbeat, more thirst, seizures, feeling very tired or weak, not hungry, unable to pass urine or change in the amount of urine produced, dry mouth, dry eyes, or very bad upset stomach or throwing up.
- Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
- Very upset stomach or throwing up.
- Any unexplained bruising or bleeding.
- Feeling very tired or weak.
- Very loose stools (diarrhea).
- Loose stools (diarrhea) that will not go away.
- Black, tarry, or bloody stools.
- Very bad and sometimes deadly lung problems have happened with Onivyde (irinotecan (liposomal)). Call your doctor right away if you have lung or breathing problems like trouble breathing, shortness of breath, or a cough that is new or worse.
What are some other side effects of Onivyde?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Loose stools (diarrhea).
- Mouth irritation or mouth sores.
- Upset stomach or throwing up.
- Not hungry.
- Hair loss.
- Feeling tired or weak.
- Weight loss.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
See also: Side effects (in more detail)
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Onivyde?
- If you need to store Onivyde (irinotecan (liposomal)) at home, talk with your doctor, nurse, or pharmacist about how to store it.
Consumer information use
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
- Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
- Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about Onivyde (irinotecan (liposomal)), please talk with your doctor, nurse, pharmacist, or other health care provider.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.