Generic Name: moxifloxacin (MOX-i-FLOX-a-sin)
Brand Name: Avelox
Moxifloxacin is associated with an increased risk of tendon problems. These include pain, swelling, inflammation, and possible breakage of tendons. The risk of tendon problems is greater in patients who are older than 60 years old, patients who take corticosteroids (eg, prednisone), or in those who have received kidney, heart, or lung transplants. The Achilles tendon in the back of the foot/ankle area is most often affected. However, problems may also occur in other tendons (eg, in the shoulder, arm, or hand). Problems may occur while you use moxifloxacin or up to several months after you stop using it.
Signs of tendon problems may include pain, soreness, redness, or swelling of a tendon or joint; bruising right after an injury in a tendon area; hearing or feeling a snap or pop in a joint or tendon area; or inability to move or bear weight on a joint or tendon area. Tell your doctor right away if you experience any of these symptoms while you use moxifloxacin or within several months after you stop using it.
Moxifloxacin may worsen muscle weakness and breathing problems in patients with myasthenia gravis. Do not use moxifloxacin if you have a history of myasthenia gravis.
Moxifloxacin is used for:
Treating infections caused by certain bacteria.
Moxifloxacin is a fluoroquinolone. It works by killing sensitive bacteria.
Do NOT use moxifloxacin if:
- you are allergic to any ingredient in moxifloxacin or to any other fluoroquinolone antibiotic (eg, levofloxacin)
- you have a certain type of irregular heartbeat (eg, QT prolongation) or uncorrected low blood potassium levels
- you have a history of myasthenia gravis
- you are taking certain antiarrhythmics (eg, amiodarone, dronedarone, procainamide, quinidine, sotalol)
Contact your doctor or health care provider right away if any of these apply to you.
Before using moxifloxacin:
Some medical conditions may interact with moxifloxacin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have a stomach infection, liver problems, brain or nervous system problems, increased pressure in the brain, Alzheimer disease, or brain blood vessel problems
- if you have a history of severe or persistent diarrhea, diabetes or high blood sugar, low blood sugar, seizures, skin sensitivity to the sun, low blood potassium levels, irregular heartbeat (eg, QT prolongation) or other heart problems (eg, fast or slow heartbeat, angina, heart failure), or heart attack, or if you have a family member with a history of irregular heartbeat (QT prolongation)
- if you have a history of joint or tendon problems; rheumatoid arthritis; kidney problems or decreased kidney function; or a heart, kidney, or lung transplant
- if you participate in strenuous physical work or exercise
- if you take any medicine that may increase the risk of a certain type of irregular heartbeat (prolonged QT interval). Check with your doctor or pharmacist if you are unsure if any of your medicines may increase the risk of this type of irregular heartbeat
Some MEDICINES MAY INTERACT with moxifloxacin. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Corticosteroids (eg, prednisone) because the risk of tendon problems may be increased
- Antiarrhythmics (eg, amiodarone, dofetilide, dronedarone, procainamide, quinidine, sotalol), cisapride, diuretics (eg, furosemide, hydrochlorothiazide), erythromycin, medicines to help mental or mood problems, or tricyclic antidepressants (eg, amitriptyline) because the risk of severe and possibly fatal irregular heartbeat may be increased
- Insulin or oral diabetes medicines (eg, glyburide) because the risk of high or low blood sugar may be increased
- Warfarin because the risk of bleeding may be increased by moxifloxacin
- Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, ketorolac) because they may increase the risk of moxifloxacin's side effects
This may not be a complete list of all interactions that may occur. Ask your health care provider if moxifloxacin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use moxifloxacin:
Use moxifloxacin as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Moxifloxacin comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get moxifloxacin refilled.
- Moxifloxacin is given as an injection at your doctor's office, hospital, or clinic. Contact a health care provider if you have any questions.
- If you miss a dose of moxifloxacin, call your doctor to find out what to do.
Ask your health care provider any questions you may have about how to use moxifloxacin.
Important safety information:
- Moxifloxacin may cause dizziness, drowsiness, light-headedness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use moxifloxacin with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Be sure to use moxifloxacin for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
- Moxifloxacin may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to moxifloxacin. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
- Mild diarrhea is common with antibiotic use. However, a more serious form of diarrhea (pseudomembranous colitis) may rarely occur. This may develop while you use the antibiotic or within several months after you stop using it. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.
- Nerve problems in the arms, hands, legs, or feet can happen in people taking moxifloxacin. These nerve problems can happen soon after moxifloxacin is started and may be permanent. Call your doctor right away if you have symptoms or nerve problems (eg, not able to handle heat or cold; decreased sensation of touch; unusual burning, numbness, tingling, pain, or weakness of the arms, hands, legs, or feet).
- A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems that may not go away, and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.
- Severe and sometimes fatal effects have rarely happened with moxifloxacin. These have included muscle or joint, kidney, liver, blood, and other problems. Talk with your doctor if you have questions.
- Moxifloxacin only works against bacteria; it does not treat viral infections (eg, the common cold).
- Do not receive certain live vaccines (oral typhoid vaccine, bacille Calmette-GuÃ©rin [BCG] vaccine) while you are taking moxifloxacin. Talk with your doctor before you receive any vaccine.
- Long-term or repeated use of moxifloxacin may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.
- Moxifloxacin has infrequently caused tendon problems, including tendon rupture. If you experience any unusual pain or swelling in your joints (eg, shoulder, elbow, hand, hip, knee, ankle, foot), contact your doctor immediately. Rest and avoid exercise or other physically stressful activity until your doctor tells you otherwise.
- Diabetes patients - Moxifloxacin may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
- Use moxifloxacin with caution in the ELDERLY; they may be more sensitive to its effects (eg, tendon problems), especially if they take corticosteroids (eg, prednisone). They may also be more sensitive to other effects (eg, irregular heartbeat).
- PREGNANCY and BREAST-FEEDING: It is not known if moxifloxacin can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using moxifloxacin while you are pregnant. It is not known if this medicine is found in breast milk. Do not breast-feed while using moxifloxacin.
Possible side effects of moxifloxacin:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Diarrhea; dizziness; headache; nausea.
Severe allergic reactions (rash; hives; itching; difficulty breathing or swallowing; tightness in the chest or throat; swelling of the mouth, face, lips, or tongue; unusual hoarseness); bloody or tarry stools; chest pain; decreased urination; fainting; fast, slow, or irregular heartbeat; fever, chills, unusual cough, or persistent sore throat; hallucinations; hearing loss or other hearing changes; inability to move or bear weight on a joint or tendon area; moderate to severe sunburn; mood or mental changes (eg, new or worsening anxiety, agitation, confusion, depression, nervousness, paranoia, restlessness); muscle pain or weakness; nightmares; pain, soreness, redness, swelling, weakness, or bruising of a tendon or joint area; red, swollen, blistered, or peeling skin; seizures; severe or persistent diarrhea; severe or persistent dizziness, headache, or light-headedness; shortness of breath or trouble breathing; stomach pain or cramps; suicidal thoughts or actions; symptoms of high or low blood sugar (eg, dizziness; fainting; fast breathing; flushing; increased sweating; increased thirst, hunger, or urination; vision changes); symptoms of liver problems (eg, dark urine; loss of appetite; pale stools; yellowing of the skin or eyes); tremor; trouble sleeping; trouble walking or unusual gait; unusual bruising or bleeding; unusual swelling or weight gain; unusual tiredness or weakness; unusual vaginal discharge, itching, or odor; vision changes (eg, blurred vision, vision loss); white patches in the mouth.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.Proper storage of moxifloxacin:
Moxifloxacin will be handled and stored by a health care provider. You will not store it at home. Keep all medicines out of the reach of children and away from pets.
- If you have any questions about moxifloxacin, please talk with your doctor, pharmacist, or other health care provider.
- Moxifloxacin is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take moxifloxacin or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about moxifloxacin. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to moxifloxacin. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using moxifloxacin.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
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