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Generic Name: Pegloticase (peg LOE ti kase)
Brand Name: Krystexxa

Medically reviewed by Last updated on Oct 12, 2020.


  • Some people have had allergic reactions or side effects during the infusion or within 2 hours of the infusion. Reactions have also happened some time after the infusion. Tell your doctor or nurse right away if you have any of these signs during or after the infusion: chest pain, chest or throat tightness, cough, dizziness or passing out, fast heartbeat, feeling nervous, redness, flushing or feeling warm, a heartbeat that does not feel normal, hives, hoarseness, itching, shortness of breath or trouble breathing, swelling of the throat or tongue, trouble swallowing, or wheezing.
  • You will be watched closely while you receive Krystexxa (pegloticase) and for some time after your dose. Talk with your doctor.
  • Other drugs will be given with Krystexxa (pegloticase) to help avoid side effects.
  • You will need to have blood work checked to see if Krystexxa (pegloticase) is still needed. Talk with your doctor.
  • Do not take Krystexxa (pegloticase) if you do not have enough of a certain enzyme (G6PD deficiency) or favism. You may need to be tested to see if you have G6PD deficiency. Tell your doctor if you are of African, Mediterranean, or South Asian descent. G6PD deficiency is more common in these people. Talk with your doctor.

Uses of Krystexxa:

  • It is used to treat gout.

What do I need to tell my doctor BEFORE I take Krystexxa?

  • If you have an allergy to pegloticase or any other part of Krystexxa (pegloticase).
  • If you are allergic to Krystexxa (pegloticase); any part of Krystexxa (pegloticase); or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
  • If you have G6PD deficiency.
  • If you are taking any of these drugs: Allopurinol or febuxostat.

This is not a list of all drugs or health problems that interact with Krystexxa (pegloticase).

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Krystexxa (pegloticase) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Krystexxa?

  • Tell all of your health care providers that you take Krystexxa (pegloticase). This includes your doctors, nurses, pharmacists, and dentists.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • You may have more gout attacks after you first start taking Krystexxa (pegloticase). Do not stop taking Krystexxa (pegloticase). You may be given other drugs to keep you from having these gout attacks. Talk with your doctor.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using Krystexxa (pegloticase) while you are pregnant.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

How is this medicine (Krystexxa) best taken?

Use Krystexxa (pegloticase) as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • It is given as an infusion into a vein over a period of time.

What do I do if I miss a dose?

  • Call your doctor to find out what to do.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Chest pain or pressure.
  • Shortness of breath, a big weight gain, or swelling in the arms or legs.

What are some other side effects of Krystexxa?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Krystexxa?

  • If you need to store Krystexxa (pegloticase) at home, talk with your doctor, nurse, or pharmacist about how to store it.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
  • This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time Krystexxa (pegloticase) is refilled. If you have any questions about Krystexxa (pegloticase), please talk with the doctor, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.