Generic Name: Ifosfamide (eye FOSS fa mide)
Brand Name: Ifex
Medically reviewed by Drugs.com. Last updated on Jan 6, 2020.
- This medicine may lower the ability of your bone marrow to make blood cells that your body needs. This can lead to needing a blood transfusion and very bad and sometimes deadly bleeding problems or infections. Tell your doctor right away if you have signs of infection like fever, chills, or sore throat; any bruising or bleeding; or if you feel very tired or weak.
- You will need your blood work checked before starting Ifex (ifosfamide) and during treatment. Talk with your doctor.
- This medicine may cause very bad and sometimes deadly nervous system problems. These include brain problems, hallucinations, and confusion. Sometimes, people have fallen into a coma. Nervous system problems may start within a few hours after getting Ifex (ifosfamide) and may last for 2 to 3 days after stopping it. Talk with the doctor.
- Kidney problems like kidney failure have happened with Ifex (ifosfamide). Tell your doctor if you have ever had kidney problems.
- This medicine may cause blood in the urine and bladder pain. Talk with the doctor.
Uses of Ifex:
- It is used to treat testicular cancer.
- It may be given to you for other reasons. Talk with the doctor.
What do I need to tell my doctor BEFORE I take Ifex?
- If you have an allergy to ifosfamide or any other part of Ifex (ifosfamide).
- If you are allergic to Ifex (ifosfamide); any part of Ifex (ifosfamide); or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
- If you have a low platelet count or a low white blood cell count.
- If you have trouble passing urine.
- If you are breast-feeding. Do not breast-feed while you take Ifex (ifosfamide).
This is not a list of all drugs or health problems that interact with Ifex (ifosfamide).
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Ifex (ifosfamide) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Ifex?
- Tell all of your health care providers that you take Ifex (ifosfamide). This includes your doctors, nurses, pharmacists, and dentists.
- Avoid driving and doing other tasks or actions that call for you to be alert until you see how Ifex (ifosfamide) affects you.
- Talk with your doctor before getting any vaccines. Use of some vaccines with Ifex (ifosfamide) may either raise the chance of an infection or make the vaccine not work as well.
- You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
- You may have more chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- Have your urine checked as you have been told by your doctor.
- If you have upset stomach, throwing up, diarrhea, or are not hungry, talk with your doctor. There may be ways to lower these side effects.
- Talk with your doctor before you drink alcohol or use other drugs and natural products that slow your actions.
- Other types of cancer may rarely happen later in life.
- Heart problems like heart failure and certain very bad abnormal heartbeats have happened with Ifex (ifosfamide). Sometimes, these heart problems have been deadly. Call your doctor right away if you have a fast or abnormal heartbeat; very bad dizziness or passing out; or shortness of breath, a big weight gain, or swelling in the arms or legs.
- Very bad and sometimes deadly lung or breathing problems have happened with Ifex (ifosfamide). Call your doctor right away if you have lung or breathing problems like trouble breathing, shortness of breath, or a cough that is new or worse.
- If you are 65 or older, use Ifex (ifosfamide) with care. You could have more side effects.
- Periods may stop in women treated with Ifex (ifosfamide). This may not go back to normal. Women treated with Ifex (ifosfamide) may go through menopause at a younger age than normal. Talk with your doctor.
- This medicine may affect fertility. Fertility problems may lead to not being able to get pregnant or father a child.
- If you are a man and have sex with a female who could get pregnant, protect her from pregnancy during treatment and for 6 months after your last dose.
- If you are a man and your sex partner gets pregnant while you take Ifex (ifosfamide) or within 6 months after your last dose, call your doctor right away.
- This medicine may cause harm to the unborn baby if you take it while you are pregnant.
- Use birth control to prevent pregnancy during treatment with Ifex (ifosfamide). You may also need to use birth control for some time after your last dose. Talk with your doctor to see if you need to use birth control after you stop Ifex (ifosfamide).
- If you get pregnant while taking Ifex (ifosfamide) or within several months after the last dose, call your doctor right away.
How is this medicine (Ifex) best taken?
Use Ifex (ifosfamide) as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- It is given as an infusion into a vein over a period of time.
- Pass urine often. You need to empty your bladder often. Drinking lots of liquids will help.
- Drink lots of noncaffeine liquids unless told to drink less liquid by your doctor.
- If you drink grapefruit juice or eat grapefruit often, talk with your doctor.
- To help with mouth sores, use a soft toothbrush or cotton swabs and rinse the mouth. Do not use mouth rinses that have alcohol in them.
What do I do if I miss a dose?
- Call your doctor to find out what to do.
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
- Signs of bleeding like throwing up or coughing up blood; vomit that looks like coffee grounds; blood in the urine; black, red, or tarry stools; bleeding from the gums; abnormal vaginal bleeding; bruises without a cause or that get bigger; or bleeding you cannot stop.
- Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
- Feeling very tired or weak.
- Feeling sleepy.
- Feeling confused.
- Dizziness or passing out.
- Hallucinations (seeing or hearing things that are not there).
- Change in eyesight, eye pain, or very bad eye irritation.
- Change in the way you act.
- Trouble controlling body movements, twitching, change in balance, trouble swallowing or speaking.
- Not able to control passing urine.
- A burning, numbness, or tingling feeling that is not normal.
- Skin wound that will not heal.
- Hearing loss.
- Ringing in ears.
- Very bad and sometimes deadly liver problems have happened with Ifex (ifosfamide). Call your doctor right away if you have signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
What are some other side effects of Ifex?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Hair loss.
- Upset stomach or throwing up.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Ifex?
- If you need to store Ifex (ifosfamide) at home, talk with your doctor, nurse, or pharmacist about how to store it.
Consumer information use
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
- Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about Ifex (ifosfamide), please talk with your doctor, nurse, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
More about Ifex (ifosfamide)
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Pricing & Coupons
- En Español
- Generic Availability
- Drug class: alkylating agents