Medically reviewed on Sep 5, 2018
The Cytoxan brand name has been discontinued in the U.S. If generic versions of this product have been approved by the FDA, there may be generic equivalents available.
Uses of Cytoxan:
- It is used to treat cancer.
- It is used to treat nephrotic syndrome.
- It may be given to you for other reasons. Talk with the doctor.
What do I need to tell my doctor BEFORE I take Cytoxan?
- If you have an allergy to cyclophosphamide or any other part of Cytoxan (cyclophosphamide injection).
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- If you have any of these health problems: Bone marrow disease or urinary tract block.
- If you are breast-feeding or plan to breast-feed.
This is not a list of all drugs or health problems that interact with Cytoxan (cyclophosphamide injection).
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Cytoxan (cyclophosphamide injection) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Cytoxan?
- Tell all of your health care providers that you take Cytoxan (cyclophosphamide injection). This includes your doctors, nurses, pharmacists, and dentists.
- Avoid driving and doing other tasks or actions that call for you to be alert or have clear eyesight until you see how Cytoxan (cyclophosphamide injection) affects you.
- Very bad and sometimes deadly allergic side effects have rarely happened. Talk with your doctor.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- Talk with your doctor before getting any vaccines. Use with Cytoxan (cyclophosphamide injection) may either raise the chance of an infection or make the vaccine not work as well.
- You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
- You may have more of a chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu. Some infections have been very bad and even deadly.
- Very bad and sometimes deadly heart problems like heart failure have happened with Cytoxan (cyclophosphamide injection). Talk with the doctor.
- Other types of cancer may rarely happen later in life.
- This medicine may affect how much of some other drugs are in your body. If you are taking other drugs, talk with your doctor. You may need to have your blood work checked more closely while taking Cytoxan (cyclophosphamide injection) with your other drugs.
- Lung problems have happened with Cytoxan (cyclophosphamide injection). Call your doctor right away if you have lung or breathing problems like trouble breathing, shortness of breath, or a cough that is new or worse.
- This medicine can cause low sodium levels. Very low sodium levels can be life-threatening, leading to seizures, passing out, trouble breathing, or death. Talk with the doctor.
- If you are 65 or older, use Cytoxan (cyclophosphamide injection) with care. You could have more side effects.
- If you are a man and have sex with a female who could get pregnant, protect her from pregnancy during care and for at least 4 months after stopping Cytoxan (cyclophosphamide injection). Use birth control that you can trust.
- If you are a man and your sex partner gets pregnant while you take Cytoxan (cyclophosphamide injection) or within 4 months after your last dose, call your doctor right away.
- This medicine may affect fertility. Fertility problems may lead to not being able to get pregnant or father a child. In both men and women, this may go back to normal but sometimes it may not. Talk with your doctor.
- Periods may stop in women treated with Cytoxan (cyclophosphamide injection). This may not go back to normal. Women treated with Cytoxan (cyclophosphamide injection) may go through menopause at a younger age than normal. Talk with your doctor.
- This medicine may cause harm to the unborn baby or loss of the unborn baby if you take it while you are pregnant.
- Use birth control that you can trust to prevent pregnancy while taking Cytoxan (cyclophosphamide injection) and for up to 12 months after Cytoxan (cyclophosphamide injection).
- If you get pregnant while taking Cytoxan (cyclophosphamide injection) or within 12 months after your last dose, call your doctor right away.
How is this medicine (Cytoxan) best taken?
Use Cytoxan (cyclophosphamide injection) as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- It is given as an infusion into a vein over a period of time.
- If you are taking Cytoxan (cyclophosphamide injection) once a day, take it in the morning. Do not take it at night unless told to do so by your doctor.
- Pass urine often. You need to empty your bladder often. Drinking lots of liquids will help.
- Drink lots of noncaffeine liquids unless told to drink less liquid by your doctor.
- If you have upset stomach, throwing up, loose stools (diarrhea), or are not hungry, talk with your doctor. There may be ways to lower these side effects.
What do I do if I miss a dose?
- Call your doctor to find out what to do.
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
- Signs of bleeding like throwing up blood or throw up that looks like coffee grounds; coughing up blood; blood in the urine; black, red, or tarry stools; bleeding from the gums; vaginal bleeding that is not normal; bruises without a reason or that get bigger; or any bleeding that is very bad or that you cannot stop.
- Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
- Signs of low sodium levels like headache, trouble focusing, memory problems, feeling confused, weakness, seizures, or change in balance.
- Feeling very tired or weak.
- Shortness of breath, a big weight gain, or swelling in the arms or legs.
- Dizziness or passing out.
- A heartbeat that does not feel normal.
- A wound that does not heal.
- Very bad and sometimes deadly urinary tract problems like hemorrhagic cystitis have happened with Cytoxan (cyclophosphamide injection). Call your doctor right away if you have blood in the urine or pain when passing urine.
- Very bad and sometimes deadly liver problems have happened with Cytoxan (cyclophosphamide injection). Call your doctor right away if you have signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
What are some other side effects of Cytoxan?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Not hungry.
- Loose stools (diarrhea).
- Hair loss.
- Upset stomach or throwing up.
- Belly pain.
- Change in color of skin.
- Change in nails.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Cytoxan?
- If you need to store Cytoxan (cyclophosphamide injection) at home, talk with your doctor, nurse, or pharmacist about how to store it.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
Consumer information use
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
- Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
- Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about Cytoxan (cyclophosphamide injection), please talk with your doctor, nurse, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
More about Cytoxan (cyclophosphamide)
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- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Images
- Drug Interactions
- Compare Alternatives
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- Drug class: alkylating agents