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Collagenase (Systemic)

Generic name: Collagenase (systemic) [ KOL-la-je-nase ]
Brand name: Xiaflex
Drug class: Miscellaneous uncategorized agents

Medically reviewed by Drugs.com. Last updated on Mar 25, 2024.

Warning

Peyronie's disease:
  • This medicine may harm the tubes in the penis. This damage may not go away. It may cause them to break during an erection. This medicine may also cause blood vessels in the penis to break. This may cause blood to collect under the skin. Call your doctor right away if you are not able to keep an erection all of a sudden. Call your doctor right away if you have pain, bruising, or swelling of the penis; a popping sound or feeling in an erect penis; trouble passing urine; or blood in the urine.

Uses of Collagenase:

What do I need to tell my doctor BEFORE I take Collagenase?

For all uses of collagenase (systemic):

Peyronie's disease:

This is not a list of all drugs or health problems that interact with collagenase (systemic).

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take collagenase (systemic) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Collagenase?

For all uses of collagenase (systemic):

Peyronie's disease:

How is this medicine (Collagenase) best taken?

Use collagenase (systemic) as ordered by your doctor. Read all information given to you. Follow all instructions closely.

For all uses of collagenase (systemic):

Dupuytren's contracture:

Peyronie's disease:

What do I do if I miss a dose?

Xiaflex, collagenase clostridium histolyticum

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

For all uses of collagenase (systemic):

Dupuytren's contracture:

What are some other side effects of Collagenase?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

For all uses of collagenase (systemic):

Dupuytren's contracture:

Peyronie's disease:

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Collagenase?

Consumer Information Use and Disclaimer

Biological Products Related to collagenase clostridium histolyticum

Find detailed information on biosimilars for this medication.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.