Generic Name: chlorpromazine (klor-PROE-ma-zeen)
Brand Name: Thorazine
Chlorpromazine suppositories are an antipsychotic. It may increase the risk of death when used to treat mental problems caused by dementia in elderly patients. Most of the deaths were linked to heart problems or infection. Chlorpromazine suppositories are not approved to treat mental problems caused by dementia. Discuss any questions or concerns with your doctor.
Chlorpromazine suppositories are used for:
Treating certain mental or mood disorders (eg, schizophrenia), the manic phase of manic-depressive disorder, anxiety and restlessness before surgery, the blood disease porphyria, severe behavioral and conduct disorders in children, nausea and vomiting, and severe hiccups. It is also used with other medicines to treat symptoms associated with tetanus. It may be used for other conditions as determined by your doctor.
Chlorpromazine suppositories are a phenothiazine. Exactly how it works is not known.
Do NOT use chlorpromazine suppositories if:
- you are allergic to any ingredient in chlorpromazine suppositories or to other phenothiazines (eg, thioridazine)
- you have severe drowsiness
- you have recently taken large amounts of alcohol or medicines that may cause drowsiness, such as barbiturates (eg, phenobarbital) or narcotic pain medicines (eg, codeine)
- you are taking certain antiarrhythmic medicines (eg, amiodarone, dofetilide, dronedarone, quinidine, sotalol), cisapride, pergolide, pimozide, quetiapine, or ziprasidone
Contact your doctor or health care provider right away if any of these apply to you.
Before using chlorpromazine suppositories:
Some medical conditions may interact with chlorpromazine suppositories. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have a history of alcohol abuse or you consume more than 3 alcoholic drinks per day
- if you have asthma, lung infection, or other lung problems (eg, emphysema); increased pressure in the eyes; glaucoma; or if you are at risk for glaucoma
- if you have a history of blood problems, enlargement of the prostate gland, epilepsy or seizures, heart problems, low blood pressure, liver problems (eg, cirrhosis), bone marrow problems, low white blood cell count, diabetes, kidney problems, neuroleptic malignant syndrome (NMS), or an adrenal gland tumor (pheochromocytoma)
- if you have Alzheimer disease, dementia, Parkinson disease, or Reye syndrome
- if you have had high blood prolactin levels or a history of certain types of cancer (eg, breast, pancreas, pituitary, brain), or if you are at risk of breast cancer
- if you are regularly exposed to extreme heat or organophosphate insecticides
Some MEDICINES MAY INTERACT with chlorpromazine suppositories. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Lithium because the risk of a severe and sometimes permanent nervous system problem (encephalopathic syndrome) characterized by weakness, lethargy, fever, tremor, confusion, or uncontrolled muscle movements may be increased
- Certain antiarrhythmic medicines (eg, amiodarone, dofetilide, dronedarone, quinidine, sotalol), cisapride, pergolide, pimozide, quetiapine, or ziprasidone because the risk of side effects, such as racing heartbeat, dizziness, fainting, and life-threatening irregular heartbeat leading to unconsciousness, may be increased by chlorpromazine suppositories
- Many prescription and nonprescription medicines (eg, used for allergies, blood clotting problems, cancer, infections, inflammation, aches and pains, heart problems, high blood pressure, high cholesterol, mental or mood problems, nausea or vomiting, Parkinson disease, seizures, stomach problems), multivitamin products, and herbal or dietary supplements (eg, herbal teas, coenzyme Q10, garlic, ginseng, gingko, St. John's wort) may interact with chlorpromazine suppositories, increasing the risk of side effects
This may not be a complete list of all interactions that may occur. Ask your health care provider if chlorpromazine suppositories may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use chlorpromazine suppositories:
Use chlorpromazine suppositories as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Wash your hands before and after using chlorpromazine suppositories. If the suppository is too soft to use, put it in the refrigerator for about 15 minutes. You may also run cold water over it. Remove the wrapper. Moisten the suppository with cool water. Lie down on your side. Insert the pointed end of the suppository into the rectum. Use your finger to push it in completely.
- Wash your hands immediately after using chlorpromazine suppositories.
- If you miss a dose of chlorpromazine suppositories, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use chlorpromazine suppositories.
Important safety information:
- Chlorpromazine suppositories may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use chlorpromazine suppositories with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Do not drink alcohol while you are using chlorpromazine suppositories.
- Check with your doctor before you use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using chlorpromazine suppositories; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
- Chlorpromazine suppositories may cause dizziness, light-headedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
- Do not become overheated in hot weather or while you are being active; heatstroke may occur.
- Chlorpromazine suppositories may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to chlorpromazine suppositories. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
- Chlorpromazine suppositories may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.
- Tell your doctor or dentist that you take chlorpromazine suppositories before you receive any medical or dental care, emergency care, or surgery.
- Some patients who take chlorpromazine suppositories may develop muscle movements that they cannot control. This is more likely to happen in elderly patients, especially women. The chance that this will happen or that it will become permanent is greater in those who take chlorpromazine suppositories in higher doses or for a long time. Muscle problems may also occur after short-term treatment with low doses. Tell your doctor at once if you have muscle problems with your arms; legs; or your tongue, face, mouth, or jaw (eg, tongue sticking out, puffing of cheeks, mouth puckering, chewing movements) while taking chlorpromazine suppositories.
- Neuroleptic malignant syndrome (NMS) is a possibly fatal syndrome that can be caused by chlorpromazine suppositories. Symptoms may include fever; stiff muscles; confusion; abnormal thinking; fast or irregular heartbeat; and sweating. Contact your doctor at once if you have any of these symptoms.
- Chlorpromazine suppositories may increase the amount of a certain hormone (prolactin) in your blood. Symptoms may include enlarged breasts, missed menstrual period, decreased sexual ability, or nipple discharge. Contact your doctor right away if you experience any of these symptoms.
- Chlorpromazine suppositories may raise or lower your blood sugar. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. Low blood sugar may make you anxious, sweaty, weak, dizzy, drowsy, or faint. It may also make your vision change; give you a headache, chills, or tremors; or make you more hungry. If these symptoms occur, tell your doctor right away.
- Diabetes patients - Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
- Chlorpromazine suppositories may cause the results of some pregnancy tests to be wrong. Check with your doctor if you have questions or concerns about your pregnancy test results.
- Chlorpromazine suppositories may interfere with certain lab tests, including phenylketonuria (PKU) tests. Be sure your doctor and lab personnel know you are taking chlorpromazine suppositories.
- Lab tests, including liver function, complete blood cell counts, and eye exams, may be performed while you use chlorpromazine suppositories. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Use chlorpromazine suppositories with caution in the ELDERLY; they may be more sensitive to its effects, especially dizziness, light-headedness (especially upon standing), rapid heartbeat, breathing problems, urinary retention, and constipation.
- Chlorpromazine suppositories should not be used in CHILDREN younger than 6 months old; safety and effectiveness in these children have not been confirmed.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using chlorpromazine suppositories while you are pregnant. Using chlorpromazine suppositories during the third trimester may result in uncontrolled muscle movements or withdrawal symptoms in the newborn. Discuss any questions or concerns with your doctor. Chlorpromazine suppositories are found in breast milk. Do not breast-feed while taking chlorpromazine suppositories.
If you stop taking chlorpromazine suppositories suddenly, you may have WITHDRAWAL symptoms. These may include nausea, vomiting, dizziness, and tremors.
Possible side effects of chlorpromazine suppositories:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Agitation; constipation; dizziness; drowsiness; dry mouth; enlarged pupils; jitteriness; nausea; stuffy nose.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); changes in menstrual period; changes in sexual ability; confusion; dark urine; difficulty swallowing; drooling; fainting; fast or irregular heartbeat; fever, chills, or sore throat; inability to move eyes; involuntary movements or spasms of the arms and legs; involuntary movements of tongue, face, mouth, or jaw (eg, sticking out of tongue, puffing of cheeks, puckering of mouth, lip-smacking, chewing movements); mask-like face; mental or mood changes, including lack of response to your surroundings; muscle restlessness; prolonged or painful erection; restlessness; seizures; severe constipation; severe or persistent dizziness; shuffling walk; sleeplessness; stiff or rigid muscles; stomach pain; sweating; tremor; trouble urinating; unusual bruising or bleeding; unusual eye movements; unusual tiredness or weakness; unusually pale skin; vision changes; yellowing of the skin or eyes.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include agitation; fainting; involuntary movements or muscle spasms; irregular heartbeat; light-headedness; loss of consciousness; restlessness; seizures; severe drowsiness or dizziness; tremors; twitching.Proper storage of chlorpromazine suppositories:
Store chlorpromazine suppositories at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep chlorpromazine suppositories out of the reach of children and away from pets.
- If you have any questions about chlorpromazine suppositories, please talk with your doctor, pharmacist, or other health care provider.
- Chlorpromazine suppositories are to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information is a summary only. It does not contain all information about chlorpromazine suppositories. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
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- Drug class: phenothiazine antiemetics
Other brands: Thorazine