Generic Name: blinatumomab (BLIN-a-TOOM-oh-mab)
Brand Name: Blincyto
A severe and sometimes fatal health problem called cytokine release syndrome (CRS) has happened in patients getting Blincyto. Call your doctor right away if you have chills, dizziness, fainting, fever, headache, nausea, rash, swelling of the face, tiredness, trouble breathing or wheezing, vomiting, or weakness.
Nerve problems have happened in patients getting Blincyto. Sometimes, nerve problems have been fatal. Call your doctor right away if you have confusion, loss of balance, passing out, seizures, or speech problems (eg, slurred speech).
Blincyto is used for:
Treating a certain type of acute lymphoblastic leukemia (ALL). It may also be used for other conditions as determined by your doctor.
Blincyto is a CD19-directed CD3 T-cell engager. It helps the body to kill certain cancer cells.
Do NOT use Blincyto if:
- are allergic to any ingredient in Blincyto
Contact your doctor or health care provider right away if any of these apply to you.
Before using Blincyto:
Some medical conditions may interact with Blincyto. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have an infection, kidney problems, or liver problems
- if you have a history of nerve problems (eg, confusion, loss of balance, seizures, speech problems)
- if you have a history of an infusion reaction after receiving Blincyto or other medicines
Some MEDICINES MAY INTERACT with Blincyto. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Cyclosporine or warfarin because the risk of their side effects may be increased by Blincyto
This may not be a complete list of all interactions that may occur. Ask your health care provider if Blincyto may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Blincyto:
Use Blincyto as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Blincyto comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Blincyto refilled.
- Blincyto will be given as an infusion at your doctor's office, hospital, or clinic. Contact your health care provider if you have any questions.
- Another medicine will be given before Blincyto to help with infusion side effects. Talk with your doctor.
- Do not throw away any of Blincyto in your trash. Follow all local rules for getting rid of it. Talk with a doctor or pharmacist if you have any questions.
- If you miss a dose of Blincyto, call your doctor to find out what to do.
Ask your health care provider any questions you may have about how to use Blincyto.
Important safety information:
- Blincyto may cause dizziness, seizures, or confusion. Do not drive or perform other possibly unsafe tasks while getting Blincyto. Discuss any questions or concerns with your doctor.
- Blincyto may lower the ability of your body to fight infection. Serious and sometimes fatal infections have happened in people getting Blincyto. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.
- A serious and possibly fatal condition called tumor lysis syndrome (TLS) has been reported in certain patients taking Blincyto. Contact your doctor right away if you develop symptoms such as fast or irregular heartbeat; fainting; decreased urination; muscle weakness or cramps; nausea, vomiting, diarrhea, or loss of appetite; or sluggishness. Discuss any questions or concerns with your doctor.
- It is important to keep the area around where Blincyto goes into the body clean. This will help reduce the risk of infection. Discuss any questions or concerns with your doctor.
- Follow the directions doctor gives you about how to use your pump closely. Do not change the settings on your pump. If there is a problem with your pump or if an alarm sounds, call your doctor or nurse right away.
- Diabetes patients - Blincyto may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
- Lab tests may be performed while you use Blincyto. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Use Blincyto with caution in the ELDERLY; they may be more sensitive to its effects.
- PREGNANCY and BREAST-FEEDING: Blincyto may cause harm to the fetus. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Blincyto while you are pregnant. It is not known if this medicine is found in breast milk. Do not breast-feed while taking Blincyto.
Possible side effects of Blincyto:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Arm or leg pain; back, bone, or joint pain; constipation; decreased appetite; diarrhea; stomach pain; trouble sleeping; weight gain.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; wheezing); chest pain; shortness of breath; swelling of the hands, ankles, or feet; symptoms of high blood sugar (eg, confusion; drowsiness; flushing; fruit-like breath odor; increased thirst, hunger, or urination; rapid breathing); symptoms of infection (eg, fever, chills, sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, wound that will not heal); symptoms of low potassium levels (eg, irregular heartbeat; muscle cramps, pain, or weakness); tremor; unusual bruising or bleeding; unusual tiredness or weakness.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.Proper storage of Blincyto:
Blincyto is usually handled and stored by a health care provider. If you receive Blincyto in a special package at home, do not open the package. Store Blincyto as directed by your pharmacist or health care provider. The package that contains Blincyto will be opened by your health care provider. Keep Blincyto out of the reach of children and away from pets.
- If you have any questions about Blincyto, please talk with your doctor, pharmacist, or other health care provider.
- Blincyto is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take Blincyto or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Blincyto. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Blincyto. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using Blincyto.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.