Generic name: betrixaban [ be-TRIX-a-ban ]
Drug class: Factor Xa inhibitors

Medically reviewed by Philip Thornton, DipPharm. Last updated on Sep 29, 2023.

What is Bevyxxa?

Bevyxxa blocks the activity of certain clotting substances in the blood.

Bevyxxa is a prescription medicine used to prevent blood clots in adults who have a serious illness and decreased ability to move. Blood clots are more likely when you are bedridden and you cannot move around.

It is not known if Bevyxxa is safe and effective in children or in people with artificial heart valves.

Warnings

Because Bevyxxa keeps your blood from clotting, this medicine can make it easier for you to bleed. Contact your doctor or seek emergency medical attention if you have unusual bruising or any bleeding that will not stop.

Tell your doctor about all other medicines you use. Many drugs can further increase your risk of bleeding while you are taking Bevyxxa.

Bevyxxa can cause a very serious blood clot around your spinal cord if you undergo a spinal tap or receive spinal anesthesia (epidural), especially if you have a genetic spinal defect, if you have a spinal catheter in place, if you have a history of spinal surgery or repeated spinal taps, or if you are also using other drugs that can affect blood clotting. This type of blood clot can lead to long-term or permanent paralysis.

Get emergency medical help if you have symptoms of a spinal cord blood clot such as back pain, numbness or muscle weakness in your lower body, or loss of bladder or bowel control.

Before taking this medicine

You should not use Bevyxxa if you are allergic to betrixaban, or if you have active or uncontrolled bleeding.

Bevyxxa may cause you to bleed more easily, especially if you have kidney disease or you use other medicines such as:

• medicines to treat or prevent blood clots;

• certain antidepressants, antibiotics, antifungal medicines, HIV medicines, or heart rhythm medicines; or

• aspirin or an NSAID (nonsteroidal anti-inflammatory drug) such as ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, or meloxicam.

Bevyxxa can cause a very serious blood clot around your spinal cord if you undergo a spinal tap or receive spinal anesthesia (epidural). This type of blood clot could cause long-term paralysis, and may be more likely to occur if:

• you have a genetic spinal defect;

• you have a spinal catheter in place or if a catheter has been recently removed;

• you have had spinal surgery, or repeated spinal taps or epidural anesthesia; or

• you take an NSAID, or use other medicines to treat or prevent blood clots.

To make sure Bevyxxa is safe for you, tell your doctor if you have ever had:

• liver or kidney disease;

• an artificial heart valve; or

• a bleeding or blood clotting disorder.

It is not known whether this medicine will harm an unborn baby. However, taking this medicine during pregnancy may increase the risk of bleeding while you are pregnant or during your delivery. Tell your doctor if you are pregnant or plan to become pregnant.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

Related/similar drugs

Eliquis, apixaban, Pradaxa, dabigatran, dalteparin, Fragmin

How should I take Bevyxxa?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Bevyxxa is usually taken once per day for up to 42 days. Follow your doctor's dosing instructions very carefully.

Take with food.

Because Bevyxxa keeps your blood from coagulating (clotting) to prevent unwanted blood clots, this medicine can also make it easier for you to bleed. Contact your doctor or seek emergency medical attention if you have unusual bruising, or any bleeding that will not stop.

If you need surgery or dental work, tell your surgeon you currently use this medicine. You may need to stop for a short time.

Do not stop taking Bevyxxa unless your doctor tells you to. Stopping suddenly can increase your risk of blood clot or stroke.

Store at room temperature away from moisture and heat.

Dosing information

Usual Adult Dose for Deep Vein Thrombosis -- Prophylaxis:

Initial dose: 160 mg orally once
Maintenance dose: 80 mg orally once a day with food
Duration of therapy: 35 to 42 days

Comments:
-Safety and effectiveness have not been established in patients with prosthetic heart valves.

Use: Prophylaxis of venous thromboembolism (VTE) in hospitalized patients with acute illness who are at risk of thromboembolic complications due to restricted mobility or other risk factors.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose may cause excessive bleeding.

What to avoid

Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.

Bevyxxa side effects

Get emergency medical help if you have signs of an allergic reaction to Bevyxxa: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Also seek emergency medical attention if you have symptoms of a spinal blood clot: back pain, numbness or muscle weakness in your lower body, or loss of bladder or bowel control.

Call your doctor at once if you have:

• easy bruising or bleeding (nosebleeds, bleeding gums, heavy menstrual bleeding);

• unexpected pain or swelling;

• any bleeding that will not stop;

• headache, dizziness, weakness, feeling like you might pass out;

• urine that looks red, pink, or brown; or

• bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds.

Common Bevyxxa side effect may include:

• bleeding.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Bevyxxa?

Tell your doctor about all your other medicines, especially:

• cyclosporine;

• St. John's wort;

• an antibiotic;

• an antidepressant;

• antiviral medicine to treat HIV/AIDS;

• heart or blood pressure medicine;

• seizure medicine;

• a blood-thinner - heparin, warfarin, or other medicines to treat or prevent blood clots; or

• NSAIDs (nonsteroidal anti-inflammatory drugs) - aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.

This list is not complete and many other drugs may interact with betrixaban. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

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Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Bevyxxa only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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