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Bevyxxa Side Effects

Generic name: betrixaban

Medically reviewed by Last updated on Sep 8, 2023.

Note: This document contains side effect information about betrixaban. Some dosage forms listed on this page may not apply to the brand name Bevyxxa.

Applies to betrixaban: oral capsule.


Oral route (Capsule)

Spinal/Epidural Hematoma: Epidural or spinal hematomas may occur in patients treated with betrixaban who are receiving neuraxial anesthesia or undergoing spinal puncture. The risk of these events may be increased by the use of in-dwelling epidural catheters or concomitant use of medical products affecting hemostasis. These hematomas may result in long-term or permanent paralysis. Consider these risks when scheduling patients for spinal procedures.

Serious side effects of Bevyxxa

Along with its needed effects, betrixaban (the active ingredient contained in Bevyxxa) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking betrixaban:

More common

Less common

Other side effects of Bevyxxa

Some side effects of betrixaban may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Incidence not known

For Healthcare Professionals

Applies to betrixaban: oral capsule.


The most common adverse events were related to bleeding.[Ref]


Common (1% to 10%): Clinically relevant non-major bleeding

Uncommon (0.1% to 1%): Major bleeding (gastrointestinal, intracranial, and fatal)


Common (1% to 10%): Hypertension[Ref]


Common (1% to 10%): Hypokalemia[Ref]


Common (1% to 10%): Constipation, nausea, diarrhea[Ref]


Common (1% to 10%): Epistaxis[Ref]

Nervous system

Common (1% to 10%): Headache[Ref]


Rare (less than 0.1%): Moderate hypersensitivity[Ref]


1. Product Information. Bevyxxa (betrixaban). Portola Pharmaceuticals. 2017.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.