Generic Name: Ofatumumab (oh fa TOOM yoo mab)
Brand Name: Arzerra
- If you have had hepatitis B before or carry the virus, Arzerra (ofatumumab) can cause the virus to become active. This can lead to very bad and sometimes deadly liver problems. You will be tested for hepatitis B before starting Arzerra (ofatumumab). You will need to watch for signs of hepatitis while taking Arzerra (ofatumumab) and for several months after stopping it. Talk with your doctor.
- A very bad brain problem called progressive multifocal leukoencephalopathy (PML) has happened with Arzerra (ofatumumab). It may cause disability or can be deadly. Tell your doctor right away if you have signs like confusion, memory problems, low mood (depression), change in the way you act, change in strength on 1 side is greater than the other, trouble speaking or thinking, change in balance, or change in eyesight.
Uses of Arzerra:
- It is used to treat a type of leukemia.
What do I need to tell my doctor BEFORE I take Arzerra?
- If you are allergic to Arzerra (ofatumumab); any part of Arzerra (ofatumumab); or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
This medicine may interact with other drugs or health problems.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Arzerra (ofatumumab) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Arzerra?
- Tell all of your health care providers that you take Arzerra (ofatumumab). This includes your doctors, nurses, pharmacists, and dentists.
- You may have more of a chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu. Some infections have been very bad and even deadly.
- You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- Talk with your doctor before getting any vaccines. Use of some vaccines with Arzerra (ofatumumab) may either raise the chance of an infection or make the vaccine not work as well.
- If you are 65 or older, use Arzerra (ofatumumab) with care. You could have more side effects.
- Tell your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding. You will need to talk about the benefits and risks to you and the baby.
- If you used Arzerra (ofatumumab) when you were pregnant, tell your baby's doctor.
How is this medicine (Arzerra) best taken?
Use Arzerra (ofatumumab) as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- It is given as an infusion into a vein over a period of time.
- Other drugs may be given to help with infusion side effects.
What do I do if I miss a dose?
- Call your doctor to find out what to do.
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
- Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
- Feeling very tired or weak.
- Any unexplained bruising or bleeding.
- Swelling in the arms or legs.
- Patients with cancer who take Arzerra (ofatumumab) may be at a greater risk of getting a severe health problem called tumor lysis syndrome (TLS).This may lead to death. Call your doctor right away if you have a fast or abnormal heartbeat; any passing out; trouble passing urine; muscle weakness or cramps; upset stomach, throwing up, diarrhea, or not able to eat; or feel sluggish.
- Very bad and sometimes deadly side effects have rarely happened during and within 24 hours after the infusion. Tell your doctor right away if you have a heartbeat that does not feel normal; back pain; chest pain or pressure; fast or slow heartbeat; fever or chills; flushing; shortness of breath; stomach pain; very bad dizziness or passing out; or very bad headache.
What are some other side effects of Arzerra?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Feeling tired or weak.
- Signs of a common cold.
- Upset stomach.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Arzerra?
- If you need to store Arzerra (ofatumumab) at home, talk with your doctor, nurse, or pharmacist about how to store it.
Consumer information use
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
- Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about Arzerra (ofatumumab), please talk with your doctor, nurse, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
More about Arzerra (ofatumumab)
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Interactions
- Pricing & Coupons
- En Español
- Drug class: CD20 monoclonal antibodies
- FDA Alerts (1)
- FDA Approval History
Other brands: Kesimpta