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Acetaminophen, Chlorpheniramine, Dextromethorphan, and Guaifenesin

Generic Name: Acetaminophen, Chlorpheniramine, Dextromethorphan, and Guaifenesin (gwye FEN e sin & DEX troe meth OR fan with a SEET a MIN oh fen, KLOR fen IR a meen, & DEX troe meth OR fan)
Brand Name: Coricidin HBP Day/Night Cold

Uses of Acetaminophen, Chlorpheniramine, Dextromethorphan, and Guaifenesin:

  • It is used to ease allergy signs.
  • It is used to thin mucus so it can be taken from the body by coughing.
  • It is used to relieve coughing.
  • It is used to ease pain and fever.

What do I need to tell my doctor BEFORE I take Acetaminophen, Chlorpheniramine, Dextromethorphan, and Guaifenesin?

  • If you have an allergy to acetaminophen, chlorpheniramine, dextromethorphan, and guaifenesin or any part of this medicine.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have taken certain drugs used for low mood (depression) like isocarboxazid, phenelzine, or tranylcypromine or drugs used for Parkinson's disease like selegiline or rasagiline in the last 14 days. Taking acetaminophen, chlorpheniramine, dextromethorphan, and guaifenesin within 14 days of those drugs can cause very bad high blood pressure.
  • If you have a cough with a lot of mucous.
  • If you have a long-term cough caused by smoking or being around smoke, or lung problems like asthma or emphysema.

This is not a list of all drugs or health problems that interact with this medicine.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take acetaminophen, chlorpheniramine, dextromethorphan, and guaifenesin with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Acetaminophen, Chlorpheniramine, Dextromethorphan, and Guaifenesin?

  • Tell all of your health care providers that you take this medicine. This includes your doctors, nurses, pharmacists, and dentists.
  • Do not take more than what your doctor told you to take. Taking more than you are told may raise your chance of very bad side effects.
  • Do not take acetaminophen, chlorpheniramine, dextromethorphan, and guaifenesin for longer than you were told by your doctor.
  • Avoid driving and doing other tasks or actions that call for you to be alert until you see how this medicine affects you.
  • Avoid drinking alcohol while taking acetaminophen, chlorpheniramine, dextromethorphan, and guaifenesin.
  • Talk with your doctor before you use other drugs and natural products that slow your actions.
  • Avoid other sources of acetaminophen. Check labels closely. Too much acetaminophen may cause problems.
  • Very bad and sometimes deadly liver problems have happened with the use of acetaminophen. Some people needed a liver transplant. Liver problems happened most often in people taking more than 4,000 mg (milligrams) in a day. People were often taking more than one drug with acetaminophen in it. Talk with your doctor.
  • Call your doctor right away if you take more than 4,000 mg (milligrams) of acetaminophen in a day, even if you feel well.
  • This medicine may affect certain lab tests. Tell all of your health care providers and lab workers that you take this medicine.
  • Use with care in children. Talk with the doctor.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using acetaminophen, chlorpheniramine, dextromethorphan, and guaifenesin while you are pregnant.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

How is this medicine (Acetaminophen, Chlorpheniramine, Dextromethorphan, and Guaifenesin) best taken?

Use this medicine as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • Take with or without food. Take with food if it causes an upset stomach.
  • Drink lots of noncaffeine liquids unless told to drink less liquid by your doctor.
  • Do not take the Day and Night products at the same time. Wait 4 hours after the last Day dose before starting the Night product.

What do I do if I miss a dose?

  • If you take acetaminophen, chlorpheniramine, dextromethorphan, and guaifenesin on a regular basis, take a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.
  • Many times this medicine is taken on an as needed basis. Do not take more often than told by the doctor.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
  • Not able to pass urine or change in how much urine is passed.
  • A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems that may not go away, and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.

What are some other side effects of Acetaminophen, Chlorpheniramine, Dextromethorphan, and Guaifenesin?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Feeling sleepy.
  • Feeling nervous and excitable.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

Side effects (in more detail)

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Acetaminophen, Chlorpheniramine, Dextromethorphan, and Guaifenesin?

  • Store at room temperature. Do not freeze.
  • Store in a dry place. Do not store in a bathroom.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Check with your pharmacist about how to throw out unused drugs.

Consumer Information Use and Disclaimer

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about acetaminophen, chlorpheniramine, dextromethorphan, and guaifenesin, please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about acetaminophen, chlorpheniramine, dextromethorphan, and guaifenesin. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using acetaminophen, chlorpheniramine, dextromethorphan, and guaifenesin.

Review Date: November 1, 2017

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