How do you stop itching from trintellix?

Yes! I started 5mg for one week, 10 mg the second week and I started 20mg the third week. I started severely itching on the bottom of my hands and within hours my feet. This started at the end of week 2 so I was still on 10 mg. I think it was helping my depression but I couldn't stand the horrible itching which was starting to spread to other parts of my body. My Dr gave me samples to try before he ordered them thru my mail in scrip company because they are expensive! He recommended if Trintellix didn't work out, he would up my Wellbutrin. I don't know if I could stand the itching another week and because I need a sleeping aid to sleep, I don't want to take anything else to make me drowsy. I'm going to try the Wellbutrin and I will post my results in two weeks. The Wellbutrin is a generic so it's very affordable. I hope you find relief and figure out what works for you. I've tried so many antidepressants.

I know this is an old question but I would like to share my experience to help others. At about 2.5 weeks on trintellix I started itching ferociously. It was there all day but got worse in the evenings. I scratched so hard I couldn’t stop and ended up with bruises and open sores. I paid out of pocket for it so I didn’t want to give up yet. I decreased the dose a little and then increased the dose more slowly. It really helped with the itching. It was gone at 4 weeks.

Was on it for 3 weeks, I had to discontinue use due to insane itching on my legs around the knee area towards the groin. Been 3 days still itchy af! I take hydroxyzine but 50mg knocks me out so I know that's not enough to stop the itch. This drug and lamictal cause rash... they say 1 to 5% for Lamictal but it sounds like it's higher... relatively newer medication..

I have been taking Trintellix for one and a half weeks and I am itching all over. I started on 10 mg for one week and increased to 20 mg. At first I thought it was the cold weather that was affecting my skin. My legs also feel slightly warm. My mood is noticeably better, but the itching is driving me crazy. Past trial of Wellbutrin made me angry. I plan to continue with Trintellix.

I was on 5 mg of T and the severe itching started immediately! The palms of my hands, the soles of my feet, my head, my arm pits... it was HORRIBLE. I endured it for 2 weeks, hoping it would subside... it only got worse! Why does it causing itching???
I had to switch meds.

I recently started this medication. 5mg. On day 6 I started itching on my neck. Day 7 I woke up with swollen eyes and covered in itchy hives. Day 8 I called the doc and they advised I stop taking the medication and take beendryl. The next day I was still covered in itchy hives. I have never had any allergies or reactions before so this was a little freaky. I went to urgent care since it was still happening 3 days after i stopped taking the meds. The doc there said it has a 66 hour half life so it would take about 16 days to be completely out of my system!! They put me on tapered dose of prednisone to suppress the itching. It worked for the first 5 days and I woke up today with swollen eyes and covered in hives yet again. I’m hoping in a few more days it will be completely out of my system. Reading these posts actually makes me feel better that it’s not just me. Did you all have hives too??? Or just itchy skin?

I have been on T for 2 weeks now. 20mg. The itching started immediately. My feet, then all over- especially before bed. It was so incredibly intense, I was using a bristle brush to scratch. It subsided, and presently, it has almost stopped. My question is, why does this medication make us itch?

I had the same problem. I felt like bugs were under my skin and i itched so much i had sores all over. It never stopped so i stopped taking it.

I have been taking Trintellix now for over a month. Started out on just 10 mg, now I am on 20 mg and the itching has been overwhelming. I thought I was having an allergic reaction to something, like fabric softener or detergent, but now that I have researched the side effects, I see now that it is the medication. I took Benadryl, and it helped ease the itching, but it of course ended up coming back. I also have been using eczema itching lotion to soothe my skin. It really makes me mad, because this has really helped me for both anxiety and depression. Hope this helps anyone else that has taken Trintellix!

Wow I've been itching for the past hour and I figure it's my trintellix because today I took 20mg instead of 10mg because I've been really depressed the past couple days.. yes I know it's bad to take more than the Dr prescribes but anyway I hope it goes away, if not I'll try some hydroxyzine

Generalized rash and itching (pruritus) is a common side effect of Trintellex, but side effects generally appear with hours or days of starting the medication. If it's occuring only after weeks I'd recommend consulting with your doctor to rule out any other underlying cause.

I've been on 10 ml myself for 6 weeks. I'm going to urgent care thisorning as I can't take the itching. It's only my arms but it's so severe itching that I've bruised my as from it. Not sure what it's from but started the Trintellix about the same time.

I too started itching a couple weeks after starting trintellix. I hope it subsides because this is the most effective med I have had for my mood after at least 10 years of treatment with different meds. My husband says I am a new person. My shakiness also subsided that must have been associated with use of zoloft.

Yes! It's horrible and I'm taking atarax and it's not helping, did it ever go away for you???

I had the intense itching as well . I waited a couple weeks and it did not subside. But the med worked so well, so I also take an antihistamine called hydroxyzine. I take 150 mg at night. This keeps me itch free for 24 hours. Because of the drowsy side effects of the hydroxyzine, I take Vyvanse 30 mg in the morning to counteract this. Yes, it is weird that I take two meds to combat side effects, but I don't mind. I have had treatment resistant depression for years and this has been the best treatment and has worked great for over two years. I also believe the Vyvanse is helping my depression. I have what is called atypical depression which means I will sleep for hours instead of waking up with insomnia. I think the Vyvanse helps me get out of bed and want to do something. The Trintellix helps my mood. By the way, the Hydroxyzine is a different category of antihistamine than what you get over the counter. You'll need a prescription for it. The first time I took it, it was sooo good to be free of the itching!