Has anyone tried Trintellix or have an opinion on it?

I turned out allergic to it to the point I was cutting myself when I was scratching so hard. Don't endure it, please... stop taking it if you do get itching immediately.

I feel like that was irresponsible of your doctor to tell you to quit your meds cold turkey. It can be hell for some people and I hope you’re doing alright with that.
I did have nausea for the first couple of weeks, though it tapered down and now I don’t have nausea at all. With me, this has curbed my appetite and I have lost a few pounds, which I was happy with because I tended to emotionally eat. It does make me have to go to the bathroom way more frequently but not diarrhea like other people have experience. This has been a good thing, makes me feel better and attributed to weight loss. I did notice that this was too strong on my period, so I may take a break that week and see if I feel better during that time. I would take my meds and get horrible hot flashes and tired.
I have tried different antidepressants but this one is different. I feel uplifted, motivated and more involved in things going on around me.

I've been on Trintellix for a little over a year and a half now and it's been great. I was originally put on lexapro for depression and anxiety. It worked for about 6mo and then stopped even with dosage increases. I'm on 20 mg and it's completely resolved the depression issues. I don't know that it's as helpful with the anxiety as the lexapro was but it's definitely improved from not being on anything and it definitely hasn't increased it at all. The only downside is the price, however I've been able to get a discount coupon from their website or my doctor for the last two years that drops it to $10 / month. It's definitely worth a try if others aren't working. I had some minor nausea when I first started it and occasionally if I take it on an empty stomach with other medications, but nothing that even comes close to outweighing the benefits I've seen.

I have been on 5mg for about 3 months now. My doc hasn't raised the dose because I am really med sensitive and 5mg was "working".

Sigh. I had high hopes for this after having so many issues with meds. Is it working? Mainly I feel "neutral". Not happy, not sad, not really anything. No motivation, some days I just can't be bothered to do anything.

Luckily, it seems to be pretty weight neutral so far. However, I am noticing a twitch under my eye, which is probably Tardive's Dyskinesia, and I get a handful of hair everytime I brush it.

I have to talk to my doc next week, probably going to have to switch meds again.

As for the nausea-- in the first week, I actually vomited twice. I learned to take it on an empty stomach with just my coffee in the morning and wait an hour or so to eat breakfast. Still queasy on occasion, but mostly resolved.

I’m on this too.(Over a year now) No one has mentioned just to ask their doctor to prescribe them a zofran. ( for nausea) That’s what I do. Just take one with it in the morning and you will not have any nausea. The doctor told me this was the #1 side affect when she prescribed it to me. Hope this helps.

Hi Janie,

I just started my second fully month of Trintellix. I started on the 10mg and 100% experienced the reported nausea - and the diarrhea and gas!! Such a great feeling. But that cleared up within 7 days. Then two weeks ago when I was bumped up to the 20mg, the same thing happened - nausea, diarrhea, gas, but after a full 7 days it died down. I'm having anxiety more than usual lately, but it could be a combination of coming off of Effexor as well as a possible new med? Trintellix has certainly helped - even within a few days of starting it - and I'm not in the deep deep depression I was when I started it. Hope it works for you.

I have just stated this drug. I have been on almost every one including the other ones mentioned. I have had nausea every morning.I have a size effect that I have found noone else who has had it. Other meds have caused low sex drive. This one has the opposite effect. It is crazy.

I was on 20MG of Lexapro. Lexapro was great for my depression/anxiety symptoms but my short-term memory went to heck. I referred to the med as “Forget-a-pro”. My Dr. took me down to 5mg and it just didn’t cut it for me. Memory still bad and the anxiety/depression crept back in. He suggested I try Trintellix. He prescribed 5mg for the first week and moved to 10mg. As others have said the nausea on day 1 hit me after an hour and stuck around for about 2 hours. I am 3 weeks in, and still have some nausea. I have an iron stomach and have NEVER been nauseous and vomited for the first time in over 25 years. I hope this side effect tapers off, because this med WORKS. Cognitively I noticed a difference in week 2. Mentally sharper, more engaged conversationally and not so dang drowsy every afternoon. From time to time I’ll have these bouts of euphoria, hard to explain but a really cool feeling when they happen. I’m sticking with it for now.

I have been taking Trintellix for almost a month now and have experienced the nausea related to it. I have discovered that if I take it on an empty stomach accompanied by my one daily cup of coffee and wait at least an hour before eating, it helps with the nausea. If you're not a coffee drinker there's a possibility that any warm beverage such as tea might help you. Good luck

Hi Janie - I am taking Trintellix and starting my 4th week. I began at 5mg, then 10mg while tapering off of Pristiq, and have been on 20 mg now for 5 days. I did experience nausea when starting both the 10 mg doses but it went away after a few days. I haven't had nausea with the 20 mg so far. I also experienced some light headedness initially but it also has gone away. There has been no weight loss or weight gain so far either. It is helping with mood and energy a little. Hope this helps.

Sapphire

I tried this drug for about 4 weeks. All it did was give me bad anxiety. I told my doctor the first week of taking it that I was having bad anxiety ( don't normally suffer from it) but he kept me on it for four weeks and then I couldn't stand it any more so went off it. I did cause me mild nausea but that side effect was overridden by the anxiety.

Hi, I tried Trintellix a couple years ago 5mg, then 10mg, for four weeks. I never had nausea or weight loss. But I stopped taking it do to pounding heart, and increased anxiety.
Of course not everyone has this problem. It may work great for you. These meds are always a shot in the dark aren't they? It gets frustrating finding one that suits you. I've been on Celexa 10mg, for over a year now and it seems to work fine for me. Plus I take ativan if anxiety gets out of hand.
I hope Trintellix works for you, I'll keep my fingers crossed. :) xx

A psychiatrist I saw mentioned that some do get sick with that drug.
Maybe you could get a second opinion. You could try to get the Genesight assessment done.
Or wean down slowly and start trying natural remedies.