I have been on different anti-depressants for 30 years TCA's, SSRI and SNRI. Some i have taken worked for periods of time for example I had been on Lexapro 20mg for about 8 years and like others it stopped working. My Doctor put me on a TCA Doxepin and worked up to 200mg at bedtime
Less depression but very dry mouth. I started 10mg Trintellix 2 weeks ago and don't notice any improvement I have had none of the listed side effects but my legs feel very weak and pain full has anyone else had this sympton?