Question posted by Bluemoonsailing on 8 Oct 2021
Last updated on 8 October 2021
I have MDD, PTSD, ADHD. Doctor prescribed me Trintellix 2 months ago in addition to Cymbalta 20mg/day,Zoloft 50mg/day.
Trintellix worked to reduce anxiety, also (not intended purpose though) my mind became sharper a bit. But I am still in "lack of battery" mood.
As I'm still prescribed other SNRI & SSRI, if I ask doctor to switch (taper off maybe) Trintellix 20mg is there a chance of good result?
Hi, Bluemoon!
"TRINTELLIX:
The recommended starting dose is 10 mg administered orally once daily without regard to meals. Dosage should then be increased to 20 mg/day, as tolerated, because higher doses demonstrated better treatment effects in trials conducted in the United States."
I would ask your doctor about taking 3 antidepressants especially Zoloft and Trintellix which are both SSRI's (Cymbalta is an atypical antidepressant) and carry the risk of a rare but serious interaction:
https://www.drugs.com/interactions-check.php?drug_list=2057-1348,949-2273,3490-18003
Hope this is helpful.
Thank you Wildcatvet!
Yes,I have concern about serotonin syndrome.I asked doctor all 3 of them are prescribed.He told me it's rare,also I tend to tolerate well to any medication,also I'm told if I feel anything weird,I should immediately call doctor.
I ended up prescribed 20mg Trintellix and 37.5mg Effexor XR.(Will go up to 75mg if nothing happens)I have to watch my blood pressure and other symptoms,usually I don't have any.
Oh,I meant,"I asked doctor "Why"all of 3 are prescribed.
Trintellix Max dosage is 20mg/day in Japan too.
I loved my Effexor and never had any side effects from it.
Good luck to you... I hope these medications will help you.
I had fatigue side effect with Trintellix 10mg. Upping to 20 just gave me more fatigue so I went back to 10. I was on this dose for 8 months but stopped because it was no longer effective for me.
Thank you! I have no side effect so far.This is one of the reasons I came up with the idea.
If there's no high blood pressure side effect I got,I would re-consider Effexor XR again.
zoloft, depression, post traumatic stress disorder, anxiety, attention-deficit hyperactivity disorder (adhd), generalized anxiety disorder, major depressive disorder, trintellix
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