Cefzil Side Effects

Generic Name: cefprozil

Note: This page contains information about the side effects of cefprozil. Some of the dosage forms included on this document may not apply to the brand name Cefzil.

Not all side effects for Cefzil may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to cefprozil: oral powder for suspension, oral tablet

In addition to its needed effects, some unwanted effects may be caused by cefprozil (the active ingredient contained in Cefzil). In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking cefprozil:

Less common
  • Black, tarry stools
  • chest pain
  • cough or hoarseness
  • diarrhea
  • fever or chills
  • lower back or side pain
  • painful or difficult urination
  • shortness of breath
  • sore throat sores, ulcers, or white spots on the lips or in the mouth
  • swollen glands
  • unusual bleeding or bruising
  • unusual tiredness or weakness
Rare
  • Abdominal or stomach cramps, pain, or tenderness
  • bleeding gums
  • blistering, peeling, or loosening of the skin
  • bloating
  • blood in the urine or stools
  • clay-colored stools
  • dark urine
  • diarrhea, watery and severe, which may also be bloody
  • difficulty with swallowing
  • dizziness
  • fast heartbeat
  • feeling of discomfort
  • headache
  • hives
  • increased thirst
  • inflammation of the joints
  • itching
  • joint or muscle pain
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • loss of appetite
  • muscle aches
  • nausea or vomiting
  • pain
  • pinpoint red spots on the skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rash
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • shortness of breath
  • swollen lymph glands
  • tightness in the chest
  • unpleasant breath odor
  • unusual weight loss
  • vomiting of blood
  • watery or bloody diarrhea
  • wheezing
  • yellow eyes or skin
Incidence not known
  • Back, leg, or stomach pains
  • bleeding gums
  • bloody or cloudy urine
  • bloody, black, or tarry stools
  • decrease in urine output or decrease in urine-concentrating ability
  • difficulty with breathing
  • fever with or without chills
  • general body swelling
  • general feeling of tiredness or weakness
  • high fever
  • nosebleeds
  • pale skin
  • sudden decrease in the amount of urine
  • swollen or painful glands

Some of the side effects that can occur with cefprozil may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common
  • Itching or pain of the vagina or genital area
  • pain during sexual intercourse
  • thick, white vaginal discharge with no odor or with a mild odor
Rare
  • Confusion
  • hives or welts
  • nervousness
  • redness of the skin
  • restlessness
  • sleepiness or unusual drowsiness
  • sleeplessness
  • trouble sitting still
  • trouble with sleeping
  • unable to sleep

For Healthcare Professionals

Applies to cefprozil: oral powder for reconstitution, oral tablet

General

Cefprozil (the active ingredient contained in Cefzil) is generally well-tolerated.[Ref]

Hypersensitivity

Up to 20% of patients with penicillin allergy may demonstrate allergy to cefprozil (the active ingredient contained in Cefzil) [Ref]

Hypersensitivity reactions have included rash (0.9%), urticaria (0.1%), anaphylaxis, angioedema, bronchospasm, eosinophilia, erythema multiforme, fever, serum-sickness-like reactions, and Stevens-Johnson syndrome.[Ref]

Gastrointestinal

Pseudomembranous colitis has been reported in patients treated with cephalosporin antibiotics. If diarrhea occurs and is unresponsive to discontinuation of the drug and/or standard therapy, pseudomembranous colitis should be considered.[Ref]

Gastrointestinal side effects have included nausea (3.5%), diarrhea (2.9%), vomiting (1%), and abdominal pain (1%). Rare cases of Clostridium difficile colitis have been reported with some cephalosporins.[Ref]

Hematologic

Hematologic side effects have included eosinophilia (2.3%), decreased leukocyte count (0.2%), and thrombocytopenia. Cephalosporins as a class have been associated with aplastic anemia, hemolytic anemia, hemorrhage, prolonged prothrombin time, positive Coombs' test, pancytopenia, neutropenia, and agranulocytosis.[Ref]

Renal

Renal side effects have included elevated serum creatinine (0.1%) and BUN (0.1%). Some other cephalosporins have included interstitial nephritis. (Reversible fever, azotemia, pyuria, and eosinophiluria are the hallmarks of cephalosporin-induced interstitial nephritis.) Cephalosporins as a class have been associated with toxic nephropathy and renal dysfunction.[Ref]

Genitourinary

Genitourinary side effects have included vaginitis and genital pruritus in 1.6% of patients.[Ref]

Hepatic

Hepatic side effects have included increased AST (2%), ALT (2%), alkaline phosphatase (0.2%), and bilirubin (<0.1%). Some cephalosporins have been associated with rare cases of cholestatic jaundice. Cephalosporins as a class have been associated with elevated LDH.[Ref]

Nervous system

Nervous system side effects have included dizziness in 1% of patients, and hyperactivity, headache, nervousness, insomnia, confusion, and somnolence in <1%. Some cephalosporins have been associated with seizures, primarily when dosages were not reduced in renally impaired patients.[Ref]

Other

Other side effects have included superinfection and diaper rash in 1.5% of patients.[Ref]

Dermatologic

Dermatologic side effects have included rash (0.9%), urticaria (0.1%), and erythema multiforme. Cefprozil (the active ingredient contained in Cefzil) has been associated with rash in a patients with infectious mononucleosis.[Ref]

References

1. Wilber RB, Doyle CA, Durham SJ, et al "Safety profile of cefprozil." Clin Infect Dis 14 (1992): s264-71

2. "Multum Information Services, Inc. Expert Review Panel"

3. "Product Information. Cefzil (cefprozil)." Bristol-Myers Squibb, Princeton, NJ.

4. "Cefprozil." Med Lett Drugs Ther 34 (1992): 63-4

5. Filipe P, Almeida RSLS, Rodrigo FG "Occupational allergic contact dermatitis from cephalosporins." Contact Dermatitis 34 (1996): 226

6. Romano A, Mayorga C, Torres MJ, Artesani MC, Suau R, Sanchez F, Perez E, Venuti A, Blanca M "Immediate allergic reactions to cephalosporins: Cross-reactivity and selective responses." J Allerg Clin Immunol 106 (2000): 1177-83

7. Christenson JC, Gooch WM, Herrod JN, Swenson E "Comparative efficacy and safety of cefprozil and cefaclor in the treatment of acute uncomplicated urinary tract infections." J Antimicrob Chemother 28 (1991): 581-6

8. Christenson JC, Swenson E, Gooch WM III, Herrod JN "Comparative efficacy and safety of cefprozil (BMY-28100) and cefaclor in the treatment of acute group A beta-hemolytic streptococcal pharyngitis." Antimicrob Agents Chemother 35 (1991): 1127-30

9. Haskell RJ, Fujita NK, Stevenson JA, Border WA "Cefoxitin-induced interstitial nephritis." Arch Intern Med 141 (1981): 1557

10. Toll LL, Lee M, Sharifi R "Cefoxitin-induced interstitial nephritis." South Med J 80 (1987): 274-5

11. Baciewicz AM, Chandra R "Cefprozil-induced rash in infectious mononucleosis." Ann Pharmacother 39 (2005): 974-5

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

Hide
(web1)