Cefzil Side Effects
Generic Name: cefprozil
Note: This page contains information about the side effects of cefprozil. Some of the dosage forms included on this document may not apply to the brand name Cefzil.
Not all side effects for Cefzil may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
For the Consumer
Applies to cefprozil: oral powder for suspension, oral tablet
In addition to its needed effects, some unwanted effects may be caused by cefprozil (the active ingredient contained in Cefzil). In the event that any of these side effects do occur, they may require medical attention.
You should check with your doctor immediately if any of these side effects occur when taking cefprozil:Less common
- Black, tarry stools
- chest pain
- cough or hoarseness
- fever or chills
- lower back or side pain
- painful or difficult urination
- shortness of breath
- sore throat sores, ulcers, or white spots on the lips or in the mouth
- swollen glands
- unusual bleeding or bruising
- unusual tiredness or weakness
- Abdominal or stomach cramps, pain, or tenderness
- bleeding gums
- blistering, peeling, or loosening of the skin
- blood in the urine or stools
- clay-colored stools
- dark urine
- diarrhea, watery and severe, which may also be bloody
- difficulty with swallowing
- fast heartbeat
- feeling of discomfort
- increased thirst
- inflammation of the joints
- joint or muscle pain
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- loss of appetite
- muscle aches
- nausea or vomiting
- pinpoint red spots on the skin
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- red skin lesions, often with a purple center
- red, irritated eyes
- shortness of breath
- swollen lymph glands
- tightness in the chest
- unpleasant breath odor
- unusual weight loss
- vomiting of blood
- watery or bloody diarrhea
- yellow eyes or skin
- Back, leg, or stomach pains
- bleeding gums
- bloody or cloudy urine
- bloody, black, or tarry stools
- decrease in urine output or decrease in urine-concentrating ability
- difficulty with breathing
- fever with or without chills
- general body swelling
- general feeling of tiredness or weakness
- high fever
- pale skin
- sudden decrease in the amount of urine
- swollen or painful glands
Some of the side effects that can occur with cefprozil may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:Less common
- Itching or pain of the vagina or genital area
- pain during sexual intercourse
- thick, white vaginal discharge with no odor or with a mild odor
- hives or welts
- redness of the skin
- sleepiness or unusual drowsiness
- trouble sitting still
- trouble with sleeping
- unable to sleep
For Healthcare Professionals
Applies to cefprozil: oral powder for reconstitution, oral tablet
Cefprozil (the active ingredient contained in Cefzil) is generally well-tolerated.
Up to 20% of patients with penicillin allergy may demonstrate allergy to cefprozil (the active ingredient contained in Cefzil)
Hypersensitivity reactions have included rash (0.9%), urticaria (0.1%), anaphylaxis, angioedema, bronchospasm, eosinophilia, erythema multiforme, fever, serum-sickness-like reactions, and Stevens-Johnson syndrome.
Pseudomembranous colitis has been reported in patients treated with cephalosporin antibiotics. If diarrhea occurs and is unresponsive to discontinuation of the drug and/or standard therapy, pseudomembranous colitis should be considered.
Gastrointestinal side effects have included nausea (3.5%), diarrhea (2.9%), vomiting (1%), and abdominal pain (1%). Rare cases of Clostridium difficile colitis have been reported with some cephalosporins.
Hematologic side effects have included eosinophilia (2.3%), decreased leukocyte count (0.2%), and thrombocytopenia. Cephalosporins as a class have been associated with aplastic anemia, hemolytic anemia, hemorrhage, prolonged prothrombin time, positive Coombs' test, pancytopenia, neutropenia, and agranulocytosis.
Renal side effects have included elevated serum creatinine (0.1%) and BUN (0.1%). Some other cephalosporins have included interstitial nephritis. (Reversible fever, azotemia, pyuria, and eosinophiluria are the hallmarks of cephalosporin-induced interstitial nephritis.) Cephalosporins as a class have been associated with toxic nephropathy and renal dysfunction.
Genitourinary side effects have included vaginitis and genital pruritus in 1.6% of patients.
Hepatic side effects have included increased AST (2%), ALT (2%), alkaline phosphatase (0.2%), and bilirubin (<0.1%). Some cephalosporins have been associated with rare cases of cholestatic jaundice. Cephalosporins as a class have been associated with elevated LDH.
Nervous system side effects have included dizziness in 1% of patients, and hyperactivity, headache, nervousness, insomnia, confusion, and somnolence in <1%. Some cephalosporins have been associated with seizures, primarily when dosages were not reduced in renally impaired patients.
Other side effects have included superinfection and diaper rash in 1.5% of patients.
Dermatologic side effects have included rash (0.9%), urticaria (0.1%), and erythema multiforme. Cefprozil (the active ingredient contained in Cefzil) has been associated with rash in a patients with infectious mononucleosis.
More about Cefzil (cefprozil)
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