Cefprozil use while Breastfeeding
Drugs containing Cefprozil: Cefzil
Cefprozil Levels and Effects while Breastfeeding
Summary of Use during Lactation
Cefprozil is acceptable to use during breastfeeding. Limited information indicates that maternal doses of cefprozil up to 1 gram produce low levels in milk that are not expected to cause adverse effects in breastfed infants. Occasionally, disruption of the infant's gastrointestinal flora, resulting in diarrhea or thrush, has been reported with cephalosporins, but these effects have not been adequately evaluated.
Drug Levels
Maternal Levels. Nine healthy women were given a single 1 gram dose of cefprozil orally 6 to 12 months postpartum. Milk levels of cis-cefprozil (which accounts for 90% of cefprozil) ranged from 0.7 to 1.3 mg/L during the 12 hours after the dose. The peak level averaged 3.4 mg/L at 6 hours after the dose. By 24 hours after the dose, milk cefprozil levels were 0.3 mg/L.[1][2] Using the peak milk level value and assuming that the trans-isomer adds an additional 10% to the peak, an exclusively breastfed infant would receive a maximum of 3.3% of the weight-adjusted maternal dosage.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Possible Effects on Lactation
Relevant published information was not found as of the revision date.
References
1. Shyu WC, Shah VR, Venitz J et al. The excretion of cefprozil (CPR) into breast milk. Clin Pharmacol Ther. 1992;51:182. Abstract.
2. Shyu WC, Shah VR, Campbell DA et al. Excretion of cefprozil into human breast milk. Antimicrob Agents Chemother. 1992;36:938-41. PMID: 1510416
Cefprozil Identification
Substance Name
CAS Registry Number
92665-29-7
Drug Class
- Antiinfective Agents
- Antibacterial Agents
- Cephalosporins
Administrative Information
LactMed Record Number
53
Information from the National Library of Medicine's LactMed Database.
Last Revision Date
2010-02-12
Disclaimer
Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
See Also...
- Cefprozil use during Pregnancy
- Cefprozil Consumer Information
- Breastfeeding Support Group
- Safe Medications during Breastfeeding
- Medicine use while Breastfeeding
- Medicine use during Pregnancy
Disclaimer: This information is not intended as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. Use of this website signifies your agreement to the Terms of Use and Online Privacy Policy.
