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Bactramycin Side Effects

Generic Name: lincomycin

Note: This page contains information about the side effects of lincomycin. Some of the dosage forms included on this document may not apply to the brand name Bactramycin.

Not all side effects for Bactramycin may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to lincomycin: capsule, solution

In addition to its needed effects, some unwanted effects may be caused by lincomycin (the active ingredient contained in Bactramycin). In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking lincomycin:

More common
  • Abdominal or stomach cramps and pain (severe)
  • abdominal tenderness
  • diarrhea (watery and severe), which may also be bloody
  • fever
Less common
  • Skin rash, redness, and itching
  • sore throat and fever
  • unusual bleeding and bruising

Note: Some of the above side effects may also occur up to several weeks after you Stop taking lincomycin.

Some of the side effects that can occur with lincomycin may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Diarrhea (mild)
  • nausea and vomiting
  • stomach pain
Less common
  • Itching of rectal or genital (sex organ) areas

For Healthcare Professionals

Applies to lincomycin: compounding powder, injectable solution, oral capsule


The onset of pseudomembranous colitis symptoms has been reported during and after antibacterial therapy.

Esophagitis was reported with oral preparations.[Ref]

Frequency not reported: Glossitis, stomatitis, nausea, vomiting, abdominal distress, persistent diarrhea, enterocolitis, antibacterial-associated diarrhea and colitis, pruritus ani, pseudomembranous colitis, Clostridium difficile associated diarrhea, esophagitis[Ref]


Some hypersensitivity reactions occurred in penicillin-sensitive patients.

A 19-year-old male patient, who had received 2 previous IM injections of lincomycin (the active ingredient contained in Bactramycin) at the age of 17 years and 1 IM injection 2 weeks prior, reported that a few minutes after his fourth IM injection he noticed a tingling sensation around his face and mouth. The patient's symptoms progressed to bright red to blue-violet skin discoloration, injection of the bulbar conjunctivae, and swelling of his face, neck, and ears. The patient recovered without incident after receiving adrenaline and betamethasone IM followed by oral prednisone with an antihistamine.[Ref]

Frequency not reported: Hypersensitivity reactions (such as angioneurotic edema, serum sickness, anaphylaxis); face, ears, and neck swelling[Ref]


Rare (less than 0.1%): Exfoliative and vesiculobullous dermatitis
Frequency not reported: Skin rashes, urticaria, pruritus, erythema multiforme (some resembling Stevens-Johnson syndrome)[Ref]


Rare (less than 0.1%): Aplastic anemia, pancytopenia
Frequency not reported: Neutropenia, leukopenia, agranulocytosis, thrombocytopenia, thrombocytopenic purpura[Ref]


Rare (less than 0.1%): Cardiopulmonary arrest
Frequency not reported: Hypotension[Ref]

Cases of hypotension after parenteral administration have been reported, especially after too rapid IV administration. Rare cases of cardiopulmonary arrest have been reported after this drug was administered IV too rapidly. In these cases, the affected patients subsequently tolerated slow infusions. A study that looked at multiple large dose administration of this drug found that when the doses were appropriately diluted and administered more slowly, cardiovascular changes did not occur.[Ref]


Frequency not reported: Jaundice, abnormal liver function tests (especially elevated serum transaminase)[Ref]


Rare (less than 0.1%): Renal dysfunction, azotemia, oliguria[Ref]


Rare (less than 0.1%): Proteinuria
Frequency not reported: Vaginitis[Ref]

Nervous system

Frequency not reported: Tinnitus, vertigo, neuromuscular blockade, metallic taste in mouth[Ref]


Frequency not reported:
-IM: Pain following injection, local irritation, pain induration, sterile abscess formation
-IV: Thrombophlebitis[Ref]


Frequency not reported: Bulbar conjunctival injection


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