Bactramycin Side Effects

Generic Name: lincomycin

Note: This page contains information about the side effects of lincomycin. Some of the dosage forms included on this document may not apply to the brand name Bactramycin.

Not all side effects for Bactramycin may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to lincomycin: capsule, solution

In addition to its needed effects, some unwanted effects may be caused by lincomycin (the active ingredient contained in Bactramycin). In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking lincomycin:

More common
  • Abdominal or stomach cramps and pain (severe)
  • abdominal tenderness
  • diarrhea (watery and severe), which may also be bloody
  • fever
Less common
  • Skin rash, redness, and itching
  • sore throat and fever
  • unusual bleeding and bruising

Note: Some of the above side effects may also occur up to several weeks after you Stop taking lincomycin.

Some of the side effects that can occur with lincomycin may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Diarrhea (mild)
  • nausea and vomiting
  • stomach pain
Less common
  • Itching of rectal or genital (sex organ) areas

For Healthcare Professionals

Applies to lincomycin: compounding powder, injectable solution, oral capsule


Gastrointestinal side effects have included glossitis, stomatitis, nausea, vomiting, diarrhea (up to 49%), colitis, pruritus ani, pseudomembranous colitis (up to 14%), and metallic taste in mouth (4%).[Ref]


A 19-year-old male patient, who had received 2 previous intramuscular injections of lincomycin (the active ingredient contained in Bactramycin) at the age of 17 years and 1 intramuscular injection 2 weeks prior, reported that a few minutes after his fourth intramuscular injection of lincomycin he noticed a tingling sensation around his face and mouth. The patient's symptoms progressed to bright red to blue-violet skin discoloration, injection of the bulbar conjunctivae, and swelling of his face, neck, and ears. The patient recovered without incident after receiving adrenaline and betamethasone intramuscularly followed by oral prednisone with an antihistamine.[Ref]

Hypersensitivity reactions have included angioneurotic edema, serum sickness, and anaphylaxis, with rare instances of erythema multiforme, some resembling Stevens-Johnson syndrome. At least one case of face, ears, and neck swelling and bulbar conjunctival injection have been reported.[Ref]


Hematologic side effects have included neutropenia, leukopenia, agranulocytosis, thrombocytopenia, and thrombocytopenic purpura. There have been rare reports of aplastic anemia and pancytopenia; however, causality could not be determined.[Ref]


Dermatologic side effects have included skin rashes, urticaria, and rarely, exfoliative and vesiculobullous dermatitis.[Ref]


Hepatic side effects have included jaundice and abnormalities in liver function tests; however, causality could not be determined.[Ref]


Renal side effects have included rare instances of azotemia, oliguria, and proteinuria.[Ref]


Cardiovascular side effects have included rare cases of cardiopulmonary arrest and hypotension after lincomycin (the active ingredient contained in Bactramycin) was administered intravenously too rapidly. In these cases, the affected patients subsequently tolerated slow infusions of lincomycin. A study that looked at multiple large dose administration of lincomycin found that when the doses were appropriately diluted and administered more slowly, cardiovascular changes did not occur.[Ref]

Nervous system

Nervous system side effects have included neuromuscular blockade.[Ref]


Genitourinary side effects have included vaginitis.[Ref]


Local side effects have included infrequent reports of pain following intramuscular administration.[Ref]


Other side effects have included tinnitus and vertigo.[Ref]


1. Novak E, Vitti TG, Panzer JD, Schlagel C, Hearron MS "Antibiotic tolerance and serum levels after intravenous administration of multiple large doses of lincomycin." Clin Pharmacol Ther 12 (1971): 793-7

2. Jaimes EC "Lincocinamides and the incidence of antibiotic-associated colitis." Clin Ther 13 (1991): 270-80

3. Mickal A, Dildy GA, Miller HJ "Lincomycin in the treatment of cervicitis and vagini in pregnancy." South Med J 59 (1966): 567-70

4. Marks MI, Shapera RM, Brazeau M "Pediatric antimicrobial therapy 3." Can Med Assoc J 109 (1973): 213-4

5. Burbige EJ, Milligan FD "Pseudomembranous colitis. Association with antibiotics and therapy with cholestyramine." JAMA 231 (1975): 1157-8

6. Scott AJ, Nicholson GI "The recognition of pseudomembranous colitis as a clinical entity." Aust N Z J Med 4 (1974): 502-9

7. Wilson DH, Cunliffe WJ, Tan SG "Letter: Lincomycin and clindamycin colitis." Br Med J 4 (1974): 288-9

8. Bartlett JG "Anti-anaerobic antibacterial agents." Lancet 2 (1982): 478-81

9. Hamilton-Miller JM "Antimicrobial agents acting against anaerobes." J Antimicrob Chemother 1 (1975): 273-89

10. Venning GR "Identification of adverse reactions to new drugs. II (continued): How were 18 important adverse reactions discovered and with what delays?" Br Med J (Clin Res Ed) 286 (1983): 365-8

11. "Letter: Lincomycin and clindamycin colitis." Br Med J 4 (1974): 591

12. Berry DD, Brouhard BH, Box QT "Adverse reactions to parenteral lincomycin." Pediatrics 67 (1981): 389-91

13. Ashton H, Beveridge GW, Stevenson CJ "Lincomycin and clindamycin." Br J Dermatol 83 (1970): 604-6

14. Keighley MR, Arabi Y, Matheson D, Alexander-Williams J "Aspects of preventing sepsis in colo-rectal surgery: results of recent clinical trials." J Antimicrob Chemother 4 Suppl C (1978): 33-8

15. Gibson GE, Rowland R, Hecker R "Diarrhoea and colitis associated with antibiotic treatment." Aust N Z J Med 5 (1975): 340-7

16. "Lincomycin and clindamycin colitis." Br Med J 4 (1974): 65-6

17. Phillips I "Past and current use of clindamycin and lincomycin." J Antimicrob Chemother 7 Suppl A (1981): 11-8

18. Munk JF, Collopy BT, Connell JL, et al. "Lincomycin-clindamycin-associated psuedomembranous colitis." Med J Aust 2 (1976): 95-7

19. Robertson MB, Breen KJ, Desmond PV, Mashford ML, McHugh AM "Incidence of antibiotic-related diarrhoea and pseudomembranous colitis: a prospective study of lincomycin, clindamycin and ampicillin." Med J Aust 1 (1977): 243-6

20. Burdon DW "Prophylaxis in surgery." J Antimicrob Chemother 7 Suppl A (1981): 19-25

21. "The macrolides and lincomycin." Br Med J 3 (1968): 233-4

22. Price DJ, O'Grady FW, Shooter RA, Weaver PC "Trial of phenyoxymethylpenicillin, phenethicillin, and lincomycin in treatment of staphylococcal sepsis in a casualty department." Br Med J 2 (1968): 407-9

23. McCool D, Miller RR "Treatment of lincomycin-caused diarrhea." JAMA 236 (1976): 1937-8

24. "Product Information. Lincocin (lincomycin)." Pharmacia and Upjohn, Kalamazoo, MI.

25. Lambert HP "Unwanted effects of antibiotics: some recent additions." J Antimicrob Chemother 1 (1975): 2-4

26. Crapp AR, Powis J, Clark C, Keighley MR, Alexander-Williams J "Letter: Postoperative pseudomembranous colitis." Br Med J 3 (1975): 227

27. Parsons RL, Beavis JP, Salfield JB "Letter: Diarrhoea and colitis associated with antibiotic therapy." Br Med J 4 (1975): 42

28. Boyd WC, DenBesten L "Subtotal colectomy for refractory pseudomembranous enterocolitis." JAMA 235 (1976): 181

29. Liner SR "Adverse reactions to parenteral lincomycin." Pediatrics 68 (1981): 615-6

30. Kinsella PL "Letter: Antibiotic diarrhoea." Br Med J 4 (1975): 580

31. George WL, Sutter VL, Finegold SM "Antimicrobial agent-induced diarrhea--a bacterial disease." J Infect Dis 136 (1977): 822-8

32. Clark CE, Thompson H, Mcleish AR, Powis SJ, Dorricott NJ, Alexander-Williams J "Pseudomembranous colitis following prophylactic antibiotics in bowel surgery." J Antimicrob Chemother 2 (1976): 167-73

33. Sanders E "Lincomycin versus erythromycin: a choice or an echo." Ann Intern Med 70 (1969): 585-90

34. Viteri AL, Howard PH, Dyck WP "The spectrum of lincomycin-clindamycin colitis." Gastroenterology 66 (1974): 1137-44

35. Scott AJ, Nicholson GI, Kerr AR "Lincomycin as a cause of pseudomembranous colitis." Lancet 2 (1973): 1232-4

36. Pittman FE, Pittman JC, Humphrey CD "Letter: Lincomycin and pseudomembranous colitis." Lancet 1 (1974): 451-2

37. Bartlett JG, Sutter VL, Finegold SM "Treatment of anaerobic infections with lincomycin and clindamycin." N Engl J Med 287 (1972): 1006-10

38. Kaplan K, Weinstein L "Lincomycin." Pediatr Clin North Am 15 (1968): 131-9

39. Mohr JA, Rhoades ER, Muchmore HG "Actinomycosis treated with lincomycin." JAMA 212 (1970): 2260-2

40. Walker WG "Hypersensitivity reaction in a patient receiving lincomycin." Can Med Assoc J 101 (1969): 130

41. Brown EB, Cunningham CE "Granulocytopenia occurring during the administration of lincomycin." JAMA 194 (1965): 668-70

42. Raff MJ "Lincomycin: thrombocytopenia?" Ann Intern Med 78 (1973): 779

43. Duncan IB, Jeans B "Lincomycin in hospital practice." Can Med Assoc J 93 (1965): 685-91

44. Daubeck JL, Daughety MJ, Petty C "Lincomycin-induced cardiac arrest: a case report and laboratory investigation." Anesth Analg 53 (1974): 563-7

45. Waisbren BA "Lincomycin in larger doses." JAMA 206 (1968): 2118

46. Darrell JH, Uttley AH "Antibiotics in the peri-operative period." Br J Anaesth 48 (1976): 13-9

47. Samuelson RJ, Giesecke AT Jr, Kallus FT, Stanley VF "Lincomycin-curare interaction." Anesth Analg 54 (1975): 103-5

48. Duignan NM, Andrews J, Williams JD "Pharmacological studies with lincomycin in late pregnancy." Br Med J 3 (1973): 75-8

49. Snavely SR, Hodges GR "The neurotoxicity of antibacterial agents." Ann Intern Med 101 (1984): 92-104

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.