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Lincomycin Pregnancy and Breastfeeding Warnings

Lincomycin is also known as: Bactramycin, L-Mycin, Lincocin, Lincorex

Lincomycin Pregnancy Warnings

Lincomycin has been assigned to pregnancy category C by the FDA. Animal studies have failed to reveal evidence of fetolethality. There are no controlled data in human pregnancy. However, lincomycin has been used in various stages of human pregnancy without evidence of fetal harm. Lincomycin is only recommended for use during pregnancy when benefit outweighs risk.

Lincomycin crosses the placenta and can achieve cord serum levels about 25% that of the mother. Following multiple intramuscular injections of 600 mg, there was no report of accumulation in the amniotic fluid. No effects on the newborn were observed. The children of 302 patients treated at different stages of pregnancy with oral lincomycin, 2 g/day for 7 days, were evaluated at various intervals up to 7 years after birth. No increases in malformations or in delayed developmental defects were observed, when compared with a control group.

Lincomycin Breastfeeding Warnings

Lincomycin concentrations of 0.5 to 2.4 mcg/mL have been reported in human milk. In one study, serum and milk levels measured 6 hours post-dose in nine patients administered lincomycin (500 mg orally every 6 hours for 3 days) averaged 1.37 and 1.28 mcg/mL, respectively, representing a milk to plasma ratio of 0.9. Much lower milk to plasma ratios of 0.13 to 0.17 have also been reported. No adverse effects have been reported in nursing infants.

Lincomycin is excreted into human milk. The effects in the nursing infant are unknown. Due to the potential for serious adverse reactions, the manufacturer recommends that a decision be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

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