Lincomycin Dosage

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Bacterial Infection

Intramuscular:
Serious infections: 600 mg IM every 24 hours
More severe infections: 600 mg IM every 12 hours, or more frequently

Intravenous:
Serious infections: 600 to 1000 mg IV every 8 to 12 hours
More severe infections: Dosage increases may be required
Life-threatening: Up to 8 g per day IV in divided doses
Dosage should be based upon the severity of the infection.

Usual Adult Dose for Bacterial Conjunctivitis

75 mg subconjunctivally one time

Usual Pediatric Dose for Bacterial Infection

2 months or older:
Intramuscular:
Serious infections: 10 mg/kg IM every 24 hours
More severe infections: 10 mg/kg IM every 12 hours, or more frequently

Intravenous: 10 to 20 mg/kg IV per day in 2 or 3 equally divided doses
Dosage should be based upon the severity of the infection.

Renal Dose Adjustments

Severe renal dysfunction: 25% to 30% of the dosage recommended for patients with normal renal function

Liver Dose Adjustments

No adjustment recommended

Precautions

If significant diarrhea occurs during treatment, lincomycin should be discontinued.

Clostridium difficile associated diarrhea (CDAD) has been reported with almost all antibiotics and may potentially be life-threatening. Therefore, it is important to consider this diagnosis in patients who present with diarrhea following lincomycin therapy. Lincomycin therapy has been associated with severe colitis which may end fatally; therefore, it should be reserved for serious infections where less toxic antimicrobial agents are inappropriate. It should not be used in patients with nonbacterial infections such as most upper respiratory tract infections. Diarrhea, colitis, and Clostridium difficile pseudomembranous colitis have been observed to begin up to several weeks following discontinuation of lincomycin. Mild cases generally improve with discontinuation of the drug, while severe cases may require supportive therapy and treatment with an antimicrobial agent effective against C difficile. Hypertoxin producing strains of C difficile cause increased morbidity and mortality; these infections can be resistant to antimicrobial treatment and may necessitate colectomy.

Severely ill elderly patients may tolerate diarrhea less well. When lincomycin is indicated in these patients, they should be carefully monitored for change in bowel frequency.

Lincomycin should be prescribed cautiously for patients with a history of gastrointestinal disease, particularly colitis, and in atopic individuals. It should also be used with caution in patients with a history of asthma or significant allergies.

Lincomycin should not be used in the treatment of meningitis because it does not diffuse adequately into the cerebrospinal fluid.

Use with caution in patients with severe renal and/or hepatic dysfunction. The lincomycin serum concentration should be monitored during high-dose treatment.

The injectable formulation contains benzyl alcohol which may cause fatal gasping syndrome in premature infants.

Lincomycin should not be administered undiluted as an intravenous bolus injection. It should be infused over at least 60 minutes; the infusion rate should not exceed 1 g per hour. The concentration should not exceed 10 mg/mL. Severe cardiopulmonary events have occurred when the recommended concentration and rate have been exceeded.

During prolonged therapy, periodic liver and kidney function tests and blood counts should be performed.

To reduce the risk of development of drug resistant organisms, antibiotics should only be used to treat or prevent proven or suspected infections caused by bacteria. Culture and susceptibility information should be considered when selecting treatment or, if no data are available, local epidemiology and susceptibility patterns may be considered when selecting empiric therapy. Patients should be advised to avoid missing doses and to complete the entire course of therapy.

Dialysis

Hemodialysis and peritoneal dialysis are not effective in removing lincomycin from the serum.

Other Comments

For use in lincomycin-sensitive microorganisms only

Maximum dose: 8 g in 24 hours

Hide
(web3)