Skip to Content

Amphetamine Side Effects

Not all side effects for amphetamine may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to amphetamine: tablets

Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; dry mouth; feeling nervous or excited; headache; loss of appetite; nausea; restlessness; trouble sleeping; unpleasant taste; upset stomach; vomiting; weight loss.

Seek medical attention right away if any of these SEVERE side effects occur while taking amphetamine:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision or other vision changes; change in sexual ability or desire; chest pain or tightness; erections that happen often or that last a long time; fainting; fast or irregular heartbeat; hallucinations; new or worsening mental, mood, or behavior changes (eg, aggression, depression, hostility); seizures; severe or persistent dizziness or headache; shortness of breath; symptoms of stroke (eg, confusion, one-sided weakness, slurred speech); tremor; uncontrolled speech or muscle movements (eg, tics).

For Healthcare Professionals

Applies to amphetamine: oral tablet


Cardiovascular side effects have included tachycardia, palpitations, and elevated blood pressure. Cardiomyopathy and myocardial infarction have been reported rarely.[Ref]

Nervous system

Nervous system side effects have included depression, seizures, stroke, overstimulation, restlessness, dizziness, insomnia, euphoria, dyskinesia, dysphoria, tremor, headache, exacerbation of motor and phonic tics, and Tourette's syndrome. Psychotic episodes at recommended doses have been reported rarely.[Ref]


Gastrointestinal side effects have included dry mouth, unpleasant taste, diarrhea, constipation, anorexia, weight loss, and other disturbances.[Ref]


Dermatologic side effects have included urticaria.[Ref]


Endocrine side effects have included impotence and changes in libido.[Ref]


Other side effects have included a significant elevation (highest in the evening) of the plasma corticosteroid levels. Amphetamines may interfere with urinary steroid determination.[Ref]


General side effects including headache (26%) and asthenia (6%) have been reported.[Ref]


1. Smith HJ, Roche AH, Jausch MF, Herdson PB "Cardiomyopathy associated with amphetamine administration." Am Heart J 91 (1976): 792-7

2. Wilens TE, Hammerness PG, Biederman J, et al. "Blood pressure changes associated with medication treatment of adults with attention-deficit/hyperactivity disorder." J Clin Psychiatry 66 (2005): 253-9

3. Ayres PR "Amphetamine cardiomyopathy [letter]." Ann Intern Med 98 (1983): 110

4. Bashour TT "Acute myocardial infarction resulting from amphetamine abuse: a spasm- thrombus interplay." Am Heart J 128 (1994): 1237-9

5. "Product Information. Adderall (amphetamine-dextroamphetamine)" Shire Richwood Pharmaceutical Company, Florence, KY.

6. Ragland AS, Ismail Y, Arsura EL "Myocardial infarction after amphetamine use." Am Heart J 125 (1993): 247-9

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.