Amphetamine Side Effects
Not all side effects for amphetamine may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
For the Consumer
Applies to amphetamine: oral tablet
If you experience any of the following serious side effects, stop taking amphetamine and seek emergency medical attention or contact your doctor immediately:
an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
an irregular heartbeat or very high blood pressure (severe headache, blurred vision); or
hallucinations, abnormal behavior, or confusion.
Other, less serious side effects may be more likely to occur. Continue to take amphetamine and talk to your doctor if you experience
restlessness or tremor;
anxiety or nervousness;
headache or dizziness;
dry mouth or an unpleasant taste in the mouth;
diarrhea or constipation; or
impotence or changes in sex drive.
Amphetamine is habit forming. You can become physically and psychologically dependent on this medication, and withdrawal effects may occur if you stop taking it suddenly after several weeks of continuous use. Talk to your doctor about stopping this medication gradually.
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.
For Healthcare Professionals
Applies to amphetamine: oral tablet
Cardiovascular side effects have included tachycardia, palpitations, and elevated blood pressure. Cardiomyopathy and myocardial infarction have been reported rarely.[Ref]
Nervous system side effects have included depression, seizures, stroke, overstimulation, restlessness, dizziness, insomnia, euphoria, dyskinesia, dysphoria, tremor, headache, exacerbation of motor and phonic tics, and Tourette's syndrome. Psychotic episodes at recommended doses have been reported rarely.[Ref]
Gastrointestinal side effects have included dry mouth, unpleasant taste, diarrhea, constipation, anorexia, weight loss, and other disturbances.[Ref]
Dermatologic side effects have included urticaria.[Ref]
Endocrine side effects have included impotence and changes in libido.[Ref]
Other side effects have included a significant elevation (highest in the evening) of the plasma corticosteroid levels. Amphetamines may interfere with urinary steroid determination.[Ref]
General side effects including headache (26%) and asthenia (6%) have been reported.[Ref]
1. Smith HJ, Roche AH, Jausch MF, Herdson PB "Cardiomyopathy associated with amphetamine administration." Am Heart J 91 (1976): 792-7
2. Wilens TE, Hammerness PG, Biederman J, et al. "Blood pressure changes associated with medication treatment of adults with attention-deficit/hyperactivity disorder." J Clin Psychiatry 66 (2005): 253-9
3. Bashour TT "Acute myocardial infarction resulting from amphetamine abuse: a spasm- thrombus interplay." Am Heart J 128 (1994): 1237-9
4. "Product Information. Adderall (amphetamine-dextroamphetamine)" Shire Richwood Pharmaceutical Company, Florence, KY.
5. Ragland AS, Ismail Y, Arsura EL "Myocardial infarction after amphetamine use." Am Heart J 125 (1993): 247-9
6. Ayres PR "Amphetamine cardiomyopathy [letter]." Ann Intern Med 98 (1983): 110
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