Flexeril Drug Interactions
Currently displaying a list of 451 drugs known to interact with Flexeril (cyclobenzaprine).
- 92 major drug interactions
- 353 moderate drug interactions
- 6 minor drug interactions
Medications known to interact with Flexeril
Note: Showing generic names only.
5
A
- abametapir topical
- abobotulinumtoxinA
- acebutolol
- acetylcarbromal
- acetylcholine ophthalmic
- aclidinium
- acrivastine
- adagrasib
- aldesleukin
- alfentanil
- alfuzosin
- allopurinol
- almotriptan
- alprazolam
- amantadine
- amifampridine
- amiloride
- amitriptyline
- amlodipine
- amobarbital
- amoxapine
- anagrelide
- apomorphine
- apraclonidine ophthalmic
- aprepitant
- aprocitentan
- aripiprazole
- armodafinil
- asenapine
- atazanavir
- atenolol
- atropine
- azatadine
- azelastine nasal
- azilsartan medoxomil
B
- baclofen
- belladonna
- benazepril
- benzgalantamine
- benztropine
- bepridil
- berotralstat
- betaxolol
- biperiden
- bisoprolol
- brexanolone
- brexpiprazole
- brimonidine ophthalmic
- brimonidine topical
- brivaracetam
- bromocriptine
- brompheniramine
- bumetanide
- buprenorphine
- bupropion
- buspirone
- butabarbital
- butalbital
- butorphanol
C
- candesartan
- cannabidiol
- cannabis
- capmatinib
- captopril
- carbachol ophthalmic
- carbamazepine
- carbetapentane
- carbinoxamine
- cariprazine
- carisoprodol
- carteolol
- carvedilol
- cenobamate
- cetirizine
- chlophedianol
- chloral hydrate
- chlorcyclizine
- chlordiazepoxide
- chlormezanone
- chlorphenesin
- chlorpheniramine
- chlorpromazine
- chlorthalidone
- citalopram
- clemastine
- clevidipine
- clidinium
- clobazam
- clomipramine
- clonazepam
- clonidine
- clorazepate
- clozapine
- codeine
- cyclizine
- cyproheptadine
D
- daridorexant
- darifenacin
- daxibotulinumtoxinA
- deferasirox
- demecarium bromide ophthalmic
- desipramine
- desvenlafaxine
- deutetrabenazine
- dexbrompheniramine
- dexchlorpheniramine
- dexfenfluramine
- dexmedetomidine
- dextromethorphan
- dezocine
- diazepam
- diazoxide
- dicyclomine
- difelikefalin
- dihydroergotamine
- diltiazem
- dimenhydrinate
- diphenhydramine
- disopyramide
- divalproex sodium
- donepezil
- doxazosin
- doxepin
- doxepin topical
- doxylamine
- dronabinol
- droperidol
- duloxetine
E
- echinacea
- echothiophate iodide ophthalmic
- efavirenz
- eletriptan
- eluxadoline
- enalapril
- enalaprilat
- entacapone
- eplerenone
- ergotamine
- escitalopram
- esketamine
- eslicarbazepine
- esmolol
- estazolam
- eszopiclone
- ethacrynic acid
- ethanol
- ethinyl estradiol
- ethosuximide
- ethotoin
- etravirine
- evening primrose
- ezogabine
F
- felbamate
- felodipine
- fenfluramine
- fentanyl
- fesoterodine
- fexinidazole
- flavoxate
- flibanserin
- fluoxetine
- fluphenazine
- flurazepam
- fluvoxamine
- fosaprepitant
- fosphenytoin
- fostamatinib
- frovatriptan
- furazolidone
- furosemide
G
- gabapentin
- gabapentin enacarbil
- galantamine
- ganaxolone
- gepirone
- ginkgo
- givosiran
- glycerol phenylbutyrate
- glycopyrrolate
- glycopyrronium topical
- grepafloxacin
- guanethidine
H
- halazepam
- haloperidol
- heroin
- hydralazine
- hydrochlorothiazide
- hydrocodone
- hydromorphone
- hydroxyprogesterone
- hydroxyzine
- hyoscyamine
I
- ifosfamide
- iloperidone
- imatinib
- imipramine
- incobotulinumtoxinA
- iohexol
- iomeprol
- iopamidol
- ipratropium
- ipratropium nasal
- irbesartan
- isocarboxazid
- isoflurophate ophthalmic
- isoniazid
- isosorbide dinitrate
- isosorbide mononitrate
- itraconazole
K
L
- labetalol
- lamotrigine
- landiolol
- lapatinib
- lasmiditan
- lemborexant
- lenacapavir
- leniolisib
- letibotulinumtoxinA
- levamlodipine
- levetiracetam
- levocetirizine
- levodopa
- levomethadyl acetate
- levomilnacipran
- levorphanol
- lidocaine
- lindane topical
- linezolid
- lithium
- lofexidine
- loperamide
- lorazepam
- lorlatinib
- losartan
- loxapine
- lumateperone
- lurasidone
M
- maprotiline
- mavorixafor
- meclizine
- melatonin
- mepenzolate
- meperidine
- mephenytoin
- mephobarbital
- meprobamate
- mesoridazine
- methadone
- methdilazine
- methohexital
- methotrimeprazine
- methscopolamine
- methsuximide
- methyclothiazide
- methylene blue
- metoclopramide
- metolazone
- metoprolol
- metrizamide
- metyrosine
- mibefradil
- midazolam
- milnacipran
- minoxidil
- mirtazapine
- mitotane
- modafinil
- molindone
- morphine
- morphine liposomal
N
- nabilone
- nadolol
- nalbuphine
- naratriptan
- nebivolol
- nefazodone
- nevirapine
- nicotine
- nifedipine
- nilotinib
- nimodipine
- niraparib
- nitroglycerin
- nitroprusside
- nortriptyline
O
- obeticholic acid
- olanzapine
- olaparib
- oliceridine
- olmesartan
- olopatadine nasal
- olutasidenib
- omaveloxolone
- onabotulinumtoxinA
- opicapone
- opium
- orphenadrine
- osilodrostat
- osimertinib
- oxazepam
- oxcarbazepine
- oxybutynin
- oxycodone
- oxymorphone
- ozanimod
P
- paliperidone
- papaverine
- paraldehyde
- paramethadione
- paroxetine
- penbutolol
- pentazocine
- pentobarbital
- perampanel
- pergolide
- perphenazine
- phenacemide
- phenelzine
- phenindamine
- phenobarbital
- phensuximide
- phentolamine
- phenytoin
- physostigmine
- physostigmine ophthalmic
- pilocarpine ophthalmic
- pimozide
- pindolol
- pirtobrutinib
- polyethylene glycol 3350 with electrolytes
- potassium chloride
- potassium citrate
- prabotulinumtoxinA
- pralsetinib
- pramipexole
- pregabalin
- primidone
- procarbazine
- prochlorperazine
- procyclidine
- promazine
- promethazine
- propantheline
- propiomazine
- propoxyphene
- propranolol
- protriptyline
- pyrilamine
Q
R
- ramelteon
- rasagiline
- rauwolfia serpentina
- remifentanil
- remimazolam
- repotrectinib
- reserpine
- revefenacin
- ribociclib
- rimabotulinumtoxinB
- risperidone
- ritlecitinib
- rivastigmine
- rizatriptan
- ropinirole
- rotigotine
- rucaparib
- rufinamide
S
- safinamide
- scopolamine
- secobarbital
- selegiline
- sertraline
- sibutramine
- silodosin
- sirolimus
- sodium oxybate
- solifenacin
- sotalol
- sparsentan
- spironolactone
- st. john's wort
- stiripentol
- sufentanil
- sumatriptan
- suvorexant
T
- tacrine
- tacrolimus
- tamsulosin
- tapentadol
- tasimelteon
- tedizolid
- telmisartan
- temazepam
- temsirolimus
- teriflunomide
- tetrabenazine
- thalidomide
- thiethylperazine
- thiopental
- thioridazine
- thiothixene
- tiagabine
- tiotropium
- tirzepatide
- tizanidine
- tolcapone
- tolterodine
- topiramate
- tramadol
- tranylcypromine
- trazodone
- triamterene
- triazolam
- trichlormethiazide
- trifluoperazine
- triflupromazine
- trihexyphenidyl
- trimeprazine
- trimethadione
- trimethobenzamide
- trimipramine
- tripelennamine
- triprolidine
- trofinetide
- trospium
- tryptophan
U
V
- valbenazine
- valerian
- valproic acid
- valsartan
- varenicline
- vemurafenib
- venlafaxine
- verapamil
- vigabatrin
- vilazodone
- viloxazine
- voriconazole
- vortioxetine
Z
Flexeril alcohol/food interactions
There is 1 alcohol/food interaction with Flexeril (cyclobenzaprine).
Flexeril disease interactions
There are 2 disease interactions with Flexeril (cyclobenzaprine) which include:
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More about Flexeril (cyclobenzaprine)
- Flexeril consumer information
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- Compare alternatives
- Reviews (237)
- Drug images
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- Dosage information
- Patient tips
- During pregnancy
- Generic availability
- Support group
- Drug class: skeletal muscle relaxants
- Breastfeeding
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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