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Cyclobenzaprine Pregnancy and Breastfeeding Warnings

Cyclobenzaprine is also known as: Amrix, Comfort Pac with Cyclobenzaprine, Fexmid, Flexeril

Cyclobenzaprine Pregnancy Warnings

FDA pregnancy category: B Use of drug is not recommended unless clearly needed. Use of adequate methods of contraception should be encouraged.

Animal studies have failed to reveal evidence of teratogenicity. There are no controlled data in human pregnancy. FDA pregnancy category B: Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.

See references

Cyclobenzaprine Breastfeeding Warnings

Caution is recommended. Excreted into human milk: Unknown Excreted into animal milk: Yes The effects in the nursing infant are unknown. Cyclobenzaprine is closely related to the tricyclic antidepressants some of which are excreted into human milk. Cyclobenzaprine is excreted into the milk of rats and achieves concentrations in the milk which are 50% of those in the rat maternal plasma.

See references

References for pregnancy information

  1. "Product Information. Flexeril (cyclobenzaprine)." Merck & Co, Inc, West Point, PA.

References for breastfeeding information

  1. "Product Information. Flexeril (cyclobenzaprine)." Merck & Co, Inc, West Point, PA.
  2. Hucker HB, Stauffer SC, Balletto AJ, White SD, Zacchei AG, Arison BH "Physiological disposition and metabolism of cyclobenzaprine in the rat, dog, rhesus monkey, and man." Drug Metab Dispos 6 (1978): 659-72

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