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Modafinil Dosage

Applies to the following strength(s): 100 mg ; 200 mg

The information at is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Narcolepsy

200 mg orally daily in the morning

Usual Adult Dose for Obstructive Sleep Apnea/Hypopnea Syndrome

200 mg orally daily in the morning

Usual Adult Dose for Shift Work Sleep Disorder

200 mg orally daily one hour prior to the start of the work shift

Usual Pediatric Dose for Attention Deficit Disorder

Not FDA approved.
Reports of serious dermatologic adverse effects and psychiatric events has resulted in the FDA's Pediatric Advisory Committee unanimously recommending that a specific warning against the use of modafinil in children be added to the manufacturer's labeling; use only if first- and second-line treatments have failed and the benefits outweigh the risks.
Children less than 30 kg: 200-340 mg once daily
Children more than 30 kg: 300-425 mg

Randomized, double-blind, placebo-controlled pediatric studies have utilized an 85 mg film-coated tablet (currently not commercially available) to provide these dosages. All studies utilized a titration method but varied the length of titration (3 weeks vs 7-9 days); clinical improvement was noted earlier in the shorter titration period.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

The manufacturer has recommended that the dose be reduced by one-half in patients with severe liver dysfunction.


Safety and effectiveness have not been established in pediatric patients under the age of 16. Serious skin rashes, including erythema multiforme major and Stevens-Johnson Syndrome have been associated with modafinil use in pediatric patients.

In elderly patients, elimination of modafinil and its metabolites may be reduced as a consequence of aging. Therefore, consideration should be given to the use of lower doses in elderly patients.


Data not available

Other Comments

While doses of 400 mg/day have been well tolerated, there is no consistent evidence that this dose has greater efficacy than the 200 mg dose.