Zofran ODT orally disintegrating tablets

Pronunciation

Generic Name: ondansetron (on-DAN-se-tron)
Brand Name: Zofran ODT

Zofran ODT orally disintegrating tablets is used for:

Preventing nausea and vomiting associated with chemotherapy, radiation treatment, or surgery. It may also be used for other conditions as determined by your doctor.

Zofran ODT orally disintegrating tablets is a serotonin 5-HT3 receptor blocker. It works by blocking a chemical thought to be a cause of nausea and vomiting in certain situations (eg, chemotherapy).

Do NOT use Zofran ODT orally disintegrating tablets if:

  • you are allergic to any ingredient in Zofran ODT orally disintegrating tablets
  • you have a certain type of irregular heartbeat (congenital long QT syndrome)
  • you are taking apomorphine

Contact your doctor or health care provider right away if any of these apply to you.

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Before using Zofran ODT orally disintegrating tablets:

Some medical conditions may interact with Zofran ODT orally disintegrating tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have had an allergic reaction to another serotonin 5-HT3 receptor blocker (eg, dolasetron, granisetron)
  • if you have liver problems, heart problems (eg, congestive heart failure, slow or irregular heartbeat, QT prolongation), electrolyte problems (eg, low potassium or magnesium levels), phenylketonuria (PKU), poor nutrition (eg, eating disorder, extreme diet), diabetes, nerve problems, or recent brain problems (eg, stroke, injury)
  • if a member of your family has a history of congenital long QT syndrome or sudden cardiac death at younger than 50 years old
  • if you take any medicine that may increase the risk of a certain type of irregular heartbeat (prolonged QT interval). Check with your doctor or pharmacist if you are unsure if any of your medicines may increase the risk of this type of irregular heartbeat

Some MEDICINES MAY INTERACT with Zofran ODT orally disintegrating tablets. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Many prescription and nonprescription medicines (eg, used for breathing problems, cancer, chest pain, depression or other mental or mood problems, fluid retention, high blood pressure, immune system suppression, infections, irregular heartbeat, nausea or vomiting, pain, sleep problems, stomach or bowel problems, swelling, Tourette syndrome), multivitamin products, or herbal or dietary supplements (eg, St. John's wort) because they may interact with Zofran ODT orally disintegrating tablets. Ask your doctor or pharmacist if you are unsure if any of your medicines might interact with Zofran ODT orally disintegrating tablets

This may not be a complete list of all interactions that may occur. Ask your health care provider if Zofran ODT orally disintegrating tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Zofran ODT orally disintegrating tablets:

Use Zofran ODT orally disintegrating tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Zofran ODT orally disintegrating tablets by mouth with or without food or water.
  • Do not remove the tablet from the blister pack until you are ready to take Zofran ODT orally disintegrating tablets. Make sure that your hands are dry when you open the blister pack. Do not push the tablet through the foil. Peel back the foil on the blister pack and place the tablet on your tongue. The tablet dissolves quickly and can be swallowed with saliva. Zofran ODT orally disintegrating tablets may be taken with or without water. Take the tablet immediately after opening the blister pack. Do not store the removed tablet for future use.
  • It is important to take Zofran ODT orally disintegrating tablets as directed to prevent nausea and vomiting. If you forget to take a dose of Zofran ODT orally disintegrating tablets, take it when you remember as directed by your doctor. If you are not sure what to do, contact your doctor or pharmacist.

Ask your health care provider any questions you may have about how to use Zofran ODT orally disintegrating tablets.

Important safety information:

  • Zofran ODT orally disintegrating tablets may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Zofran ODT orally disintegrating tablets with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Serotonin syndrome is a possibly fatal syndrome that can be caused by Zofran ODT orally disintegrating tablets. Your risk may be greater if you take Zofran ODT orally disintegrating tablets with certain other medicines (eg, certain medicines used to treat depression, pain, migraines). Symptoms may include agitation; confusion; hallucinations; coma; fever; fast or irregular heartbeat; tremor; excessive sweating; and nausea, vomiting, or diarrhea. Contact your doctor at once if you have any of these symptoms.
  • Some of these products contain phenylalanine. If you must have a diet that is low in phenylalanine, ask your pharmacist if it is in your product.
  • Use Zofran ODT orally disintegrating tablets with caution in the ELDERLY; they may be more sensitive to its effects.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Zofran ODT orally disintegrating tablets while you are pregnant. It is not known if Zofran ODT orally disintegrating tablets is found in breast milk. If you are or will be breast-feeding while you use Zofran ODT orally disintegrating tablets, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Zofran ODT orally disintegrating tablets:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; drowsiness; headache; tiredness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue; wheezing; unusual hoarseness); abnormal thinking; agitation; chest pain; coma; confusion; diarrhea; dizziness or light-headedness; fainting; fast, slow, or irregular heartbeat; fever; hallucinations; nausea or vomiting that is new or worse; seizures; skin tingling or numbness; stiff muscles; stomach pain; sweating; tremor; trouble urinating; uncontrollable or involuntary muscle movements; vision changes (including sudden temporary blindness).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Zofran ODT orally disintegrating tablets:

Store Zofran ODT orally disintegrating tablets between 36 and 86 degrees F (2 and 30 degrees C) in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Zofran ODT orally disintegrating tablets out of the reach of children and away from pets.

General information:

  • If you have any questions about Zofran ODT orally disintegrating tablets, please talk with your doctor, pharmacist, or other health care provider.
  • Zofran ODT orally disintegrating tablets is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Zofran ODT orally disintegrating tablets or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Zofran ODT orally disintegrating tablets. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Zofran ODT orally disintegrating tablets. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using Zofran ODT orally disintegrating tablets.

Issue Date: December 3, 2014
Database Edition 14.4.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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