Generic Name: ondansetron (oral) (on DAN se tron)
Brand Names: Zofran, Zofran ODT, Zuplenz
What is Zuplenz?
Zuplenz (ondansetron) blocks the actions of chemicals in the body that can trigger nausea and vomiting.
Zuplenz is not for preventing nausea or vomiting that is caused by factors other than cancer treatment or surgery.
You should not use Zuplenz if you are allergic to ondansetron or to similar medicines such as dolasetron (Anzemet), granisetron (Kytril), or palonosetron (Aloxi). Do not take Zuplenz if you are also using apomorphine (Apokyn).
Before taking Zuplenz, tell your doctor if you have liver disease, or a personal or family history of Long QT syndrome.
The serious side effects of this medication include blurred vision or temporary vision loss (lasting from only a few minutes to several hours), slow heart rate, trouble breathing, anxiety, agitation, shivering, feeling like you might pass out, and urinating less than usual or not at all. Stop taking Zuplenz and call your doctor at once if you have any of these side effects. Zuplenz may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Before taking this medicine?
You should not use Zuplenz if you are also using apomorphine (Apokyn).
To make sure Zuplenz is safe for you, tell your doctor if you have:
liver disease; or
if you are allergic to medicines similar ondansetron (dolasetron, granisetron, palonosetron).
FDA pregnancy category B. Zuplenz is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.
See also: Pregnancy and breastfeeding warnings (in more detail)
It is not known whether ondansetron passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
Zuplenz should not be given to a child younger than 4 years old.
How should I take Zuplenz?
Use Zuplenz exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
To use Zuplenz oral soluble film (strip):
Keep the strip in the foil pouch until you are ready to use the medicine.
Using dry hands, remove the strip and place it on top of your tongue. It will begin to dissolve right away.
Do not chew or swallow the strip whole. Allow it to dissolve in your mouth without chewing.
Swallow several times after the strip dissolves. If desired, you may drink liquid to help swallow the dissolved strip.
Wash your hands after using Zuplenz.
Store at room temperature away from moisture, heat, and light. Keep Zuplenz in the foil pouch until ready to use. Keep foil pouches in the carton. Use the Zuplenz film imediately after you remove it from the pouch.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include sudden loss of vision, severe constipation, feeling light-headed, or fainting.
What should I avoid while taking Zuplenz?
Zuplenz may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Zuplenz side effects
Get emergency medical help if you have any of these signs of an allergic reaction to Zuplenz: rash, hives; fever, chills, difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
fast or pounding heartbeats;
jaundice (yellowing of the skin or eyes); or
blurred vision or temporary vision loss (lasting from only a few minutes to several hours).
Common Zuplenz side effects may include:
diarrhea or constipation;
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect Zuplenz?
There are many other medicines that can increase your risk of heart rhythm problems if you use them together with Zuplenz.
Tell your doctor about all other medicines you use, especially:
arsenic trioxide (Trisenox);
tramadol (Ultram, Ultracet);
an antibiotic such as clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), levofloxacin (Levaquin), moxifloxacin (Avelox), pentamidine (NebuPent, Pentam), or rifampin (Rifadin, Rimactane, Rifater);
an antidepressant such as amitriptylline (Elavil, Vanatrip, Limbitrol), clomipramine (Anafranil), or desipramine (Norpramin);
anti-malaria medications such as chloroquine (Aralen) or mefloquine (Lariam);
heart rhythm medicine such as amiodarone (Cordarone, Pacerone), dofetilide (Tikosyn), disopyramide (Norpace), dronedarone (Multaq), ibutilide (Corvert), procainamide (Procan, Pronestyl), propafenone (Rythmol), quinidine (Quin-G), or sotalol (Betapace);
medicine to prevent or treat nausea and vomiting such as dolasetron (Anzemet), droperidol (Inapsine), or ondansetron;
medicines to treat psychiatric disorders, such as chlorpromazine (Thorazine), clozapine (FazaClo, Clozaril), haloperidol (Haldol), pimozide (Orap), thioridazine (Mellaril), or ziprasidone (Geodon);
migraine headache medicine such as sumatriptan (Imitrex, Treximet) or zolmitriptan (Zomig);
narcotic medication such as methadone (Methadose, Diskets, Dolophine); or
seizure medication such as carbamazepine (Carbatrol, Tegretol), phenytoin (Dilantin), or phenobarbital (Luminal).
This list is not complete and other drugs may interact with Zuplenz. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
More about Zuplenz (ondansetron)
Related treatment guides
Where can I get more information?
- Your pharmacist can provide more information about Zuplenz.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Zuplenz only for the indication prescribed.
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Copyright 1996-2014 Cerner Multum, Inc. Version: 11.01. Revision Date: 2014-06-26, 11:40:53 AM.