Zofran

Pronunciation

Generic Name: ondansetron (oral) (on DAN se tron)
Brand Names: Zofran, Zofran ODT, Zuplenz

What is Zofran?

Zofran (ondansetron) blocks the actions of chemicals in the body that can trigger nausea and vomiting.

Zofran is used to prevent nausea and vomiting that may be caused by surgery or by medicine to treat cancer (chemotherapy or radiation).

Zofran is not for preventing nausea or vomiting that is caused by factors other than cancer treatment or surgery.

Important information

You should not use Zofran if you are allergic to ondansetron or to similar medicines such as dolasetron (Anzemet), granisetron (Kytril), or palonosetron (Aloxi). Do not take this medicine if you are also using apomorphine (Apokyn).

Before taking Zofran, tell your doctor if you have liver disease, or a personal or family history of Long QT syndrome.

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Zofran orally disintegrating tablets may contain phenylalanine. Tell your doctor if you have phenylketonuria (PKU).

The serious side effects of this medication include blurred vision or temporary vision loss (lasting from only a few minutes to several hours), slow heart rate, trouble breathing, anxiety, agitation, shivering, feeling like you might pass out, and urinating less than usual or not at all. Stop taking Zofran and call your doctor at once if you have any of these side effects. Zofran may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Before taking this medicine?

You should not use Zofran if you are also using apomorphine (Apokyn).

To make sure Zofran is safe for you, tell your doctor if you have:

  • liver disease; or

  • if you are allergic to medicines similar ondansetron (dolasetron, granisetron, palonosetron).

FDA pregnancy category B. Zofran is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

See also: Pregnancy and breastfeeding warnings (in more detail)

It is not known whether ondansetron passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Ondansetron should not be given to a child younger than 4 years old.

Zofran orally disintegrating tablets may contain phenylalanine. Tell your doctor if you have phenylketonuria (PKU).

How should I take Zofran?

Take Zofran exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Zofran can be taken with or without food.

The first dose of Zofran is usually taken before the start of your surgery, chemotherapy, or radiation treatment. Follow your doctor's dosing instructions very carefully.

Take the regular tablet with a full glass of water.

To take the orally disintegrating tablet (Zofran ODT):

  • Keep the tablet in its blister pack until you are ready to take it. Open the package and peel back the foil. Do not push a tablet through the foil or you may damage the tablet.

  • Use dry hands to remove the tablet and place it in your mouth.

  • Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing.

  • Swallow several times as the tablet dissolves.

  • Measure the oral solution with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

    Store at room temperature away from moisture, heat, and light.

    What happens if I miss a dose?

    Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

    What happens if I overdose?

    Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

    Overdose symptoms may include sudden loss of vision, severe constipation, feeling light-headed, or fainting.

    What should I avoid while taking Zofran?

    Zofran may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

    Zofran side effects

    Get emergency medical help if you have any of these signs of an allergic reaction to Zofran: rash, hives; fever, chills, difficult breathing; swelling of your face, lips, tongue, or throat.

    Call your doctor at once if you have:

    • fast or pounding heartbeats;

    • jaundice (yellowing of the skin or eyes); or

    • blurred vision or temporary vision loss (lasting from only a few minutes to several hours).

    Common Zofran side effects may include:

    • diarrhea or constipation;

    • headache;

    • drowsiness; or

    • tired feeling.

    This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    See also: Side effects (in more detail)

    What other drugs will affect Zofran?

    There are many other medicines that can increase your risk of heart rhythm problems if you use them together with Zofran.

    Tell your doctor about all other medicines you use, especially:

    • arsenic trioxide (Trisenox);

    • tacrolimus (Prograf);

    • tramadol (Ultram, Ultracet);

    • an antibiotic such as clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), levofloxacin (Levaquin), moxifloxacin (Avelox), pentamidine (NebuPent, Pentam), or rifampin (Rifadin, Rimactane, Rifater);

    • an antidepressant such as amitriptylline (Elavil, Vanatrip, Limbitrol), clomipramine (Anafranil), or desipramine (Norpramin);

    • anti-malaria medications such as chloroquine (Aralen) or mefloquine (Lariam);

    • heart rhythm medicine such as amiodarone (Cordarone, Pacerone), dofetilide (Tikosyn), disopyramide (Norpace), dronedarone (Multaq), ibutilide (Corvert), procainamide (Procan, Pronestyl), propafenone (Rythmol), quinidine (Quin-G), or sotalol (Betapace);

    • medicine to prevent or treat nausea and vomiting such as dolasetron (Anzemet), droperidol (Inapsine), or ondansetron;

    • medicines to treat psychiatric disorders, such as chlorpromazine (Thorazine), clozapine (FazaClo, Clozaril), haloperidol (Haldol), pimozide (Orap), thioridazine (Mellaril), or ziprasidone (Geodon);

    • migraine headache medicine such as sumatriptan (Imitrex, Treximet) or zolmitriptan (Zomig);

    • narcotic medication such as methadone (Methadose, Diskets, Dolophine); or

    • seizure medication such as carbamazepine (Carbatrol, Tegretol), phenytoin (Dilantin), or phenobarbital (Luminal).

    This list is not complete and other drugs may interact with ondansetron. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

    Where can I get more information?

    • Your pharmacist can provide more information about Zofran.
    • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
    • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

    Copyright 1996-2014 Cerner Multum, Inc. Version: 11.01. Revision Date: 2014-06-26, 11:40:53 AM.

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