Generic Name: ondansetron (oral) (on DAN se tron)
Brand Name: Zofran, Zofran ODT, Zuplenz
What is ondansetron?
Ondansetron blocks the actions of chemicals in the body that can trigger nausea and vomiting.
Ondansetron is used to prevent nausea and vomiting that may be caused by surgery or by medicine to treat cancer (chemotherapy or radiation).
Ondansetron is not for preventing nausea or vomiting that is caused by factors other than cancer treatment or surgery.
Ondansetron may be used for purposes not listed in this medication guide.
What is the most important information I should know about ondansetron?
You should not use ondansetron if you are also using apomorphine (Apokyn).
What should I discuss with my health care provider before taking ondansetron?
You should not use ondansetron if you are also using apomorphine (Apokyn).
To make sure ondansetron is safe for you, tell your doctor if you have:
liver disease; or
if you are allergic to medicines similar ondansetron (dolasetron, granisetron, palonosetron).
FDA pregnancy category B. Ondansetron is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.
It is not known whether ondansetron passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
Ondansetron should not be given to a child younger than 4 years old.
Ondansetron orally disintegrating tablets may contain phenylalanine. Tell your doctor if you have phenylketonuria (PKU).
How should I take ondansetron?
Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Ondansetron can be taken with or without food.
The first dose of ondansetron is usually taken before the start of your surgery, chemotherapy, or radiation treatment. Follow your doctor's dosing instructions very carefully.
Take the ondansetron regular tablet with a full glass of water.
To take the orally disintegrating tablet (Zofran ODT):
Keep the tablet in its blister pack until you are ready to take it. Open the package and peel back the foil. Do not push a tablet through the foil or you may damage the tablet.
Use dry hands to remove the tablet and place it in your mouth.
Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing.
Swallow several times as the tablet dissolves.
To use ondansetron oral soluble film (strip) (Zuplenz):
Keep the strip in the foil pouch until you are ready to use the medicine.
Using dry hands, remove the strip and place it on your tongue. It will begin to dissolve right away.
Do not swallow the strip whole. Allow it to dissolve in your mouth without chewing.
Swallow several times after the strip dissolves. If desired, you may drink liquid to help swallow the dissolved strip.
Wash your hands after using Zuplenz.
Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.
Store at room temperature away from moisture, heat, and light.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include sudden loss of vision, severe constipation, feeling light-headed, or fainting.
What should I avoid while taking ondansetron?
Ondansetron may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Ondansetron side effects
Get emergency medical help if you have any of these signs of an allergic reaction: rash, hives; fever, chills, difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
fast or pounding heartbeats;
jaundice (yellowing of the skin or eyes);
blurred vision or temporary vision loss (lasting from only a few minutes to several hours); or
high levels of serotonin in the body--agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting.
Common side effects may include:
diarrhea or constipation;
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect ondansetron?
There are many other medicines that can increase your risk of heart rhythm problems if you use them together with ondansetron.
Tell your doctor about all medicines you use, and those you start or stop using during your treatment with ondansetron, especially:
an antibiotic--azithromycin, clarithromycin, erythromycin, levofloxacin, moxifloxacin, pentamidine;
cancer medicine--arsenic trioxide, vandetanib;
an antidepressant--citalopram, escitalopram;
anti-malaria medication--chloroquine, halofantrine;
heart rhythm medicine--amiodarone, disopyramide, dofetilide, dronedarone, flecainide, ibutilide, quinidine, sotalol; or
medicine to treat a psychiatric disorder--chlorpromazine, haloperidol, pimozide, thioridazine.
This list is not complete. Other drugs may interact with ondansetron, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
More about Zofran ODT (ondansetron)
- Zofran ODT orally disintegrating tablets
- Zofran ODT (Advanced Reading)
- Zofran ODT Oral, Oromucosal (Advanced Reading)
- Other brands: Zuplenz
Related treatment guides
Where can I get more information?
- Your pharmacist can provide more information about ondansetron.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2012 Cerner Multum, Inc. Version: 11.02. Revision Date: 2014-10-28, 2:45:25 PM.