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Moexipril

Generic Name: moexipril (moe-EX-i-pril)
Brand Name: Univasc

Moexipril can cause injury and possibly death to a developing fetus when used during pregnancy. Contact your doctor at once if you suspect that you are pregnant. If you are planning to become pregnant, talk with your doctor about other treatment options.


Moexipril is used for:

Treating high blood pressure. It may be used alone or with other medicines. It may also be used to treat certain conditions as determined by your doctor.

Moexipril is an angiotensin-converting enzyme (ACE) inhibitor. It works by relaxing blood vessels. This helps to lower blood pressure.

Do NOT use moexipril if:

  • you are allergic to any ingredient in moexipril
  • you have a history of angioedema (swelling of the hands, face, lips, eyes, throat, or tongue; difficulty swallowing or breathing; or hoarseness), including angioedema caused by treatment with an ACE inhibitor
  • you are pregnant
  • you are taking a medicine that contains aliskiren and you also have diabetes or kidney problems. Check with your doctor or pharmacist if you are not sure if a medicine you take contains aliskiren

Contact your doctor or health care provider right away if any of these apply to you.

Before using moexipril:

Some medical conditions may interact with moexipril. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are able to become pregnant
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of bone marrow problems, blood vessel problems, blood flow problems, heart problems (eg, heart failure), kidney problems (eg, renal artery stenosis), liver problems, diabetes, or an autoimmune disease (eg, rheumatoid arthritis, lupus, scleroderma)
  • if you have a history of stroke, recent heart attack, or kidney transplant
  • if you are dehydrated or have low blood volume
  • if you have high blood potassium levels, low blood sodium levels, or are on a low-salt (sodium) diet
  • if you are on dialysis, or are scheduled to have surgery or receive anesthesia
  • if you are receiving treatments to reduce sensitivity to bee or wasp stings

Some MEDICINES MAY INTERACT with moexipril. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Dextran sulfate or diuretics (eg, furosemide, hydrochlorothiazide) because they may increase the risk of moexipril's side effects, such as low blood pressure
  • Everolimus or sirolimus because of the risk of angioedema may be increased
  • Aliskiren or angiotensin II receptor blockers (eg, valsartan) because the risk of certain side effects (eg, kidney problems, high blood potassium levels, low blood pressure) may be increased
  • Eplerenone, potassium-sparing diuretics (eg, amiloride, spironolactone, triamterene), potassium supplements, or trimethoprim because the risk of high blood potassium levels may be increased
  • Certain gold-containing medicines (eg, sodium aurothiomalate) because flushing, nausea, vomiting, and low blood pressure may occur
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, indomethacin, celecoxib) because they may decrease moexipril's effectiveness and the risk of kidney problems may be increased
  • Insulin or other diabetes medicines (eg, glyburide, metformin) because the risk of low blood sugar may be increased
  • Lithium or thiopurines (eg, azathioprine) because the risk of their side effects may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if moexipril may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use moexipril:

Use moexipril as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take moexipril 1 hour before meals, unless your doctor directs you otherwise.
  • Drink plenty of fluids while taking moexipril. Not drinking enough fluids or excessive sweating, diarrhea, or vomiting can lead to light-headedness or fainting.
  • Continue to take moexipril even if you feel well. Do not miss any doses.
  • If you miss a dose of moexipril, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use moexipril.

Important safety information:

  • Moexipril may cause dizziness, light-headedness, or fainting. These effects may be worse if you take it with alcohol or certain medicines. Use moexipril with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Moexipril may cause dizziness, light-headedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Dehydration, excessive sweating, vomiting, or diarrhea may increase the risk of low blood pressure. Contact your health care provider at once if any of these occur.
  • Do not stop taking moexipril or change your dose of moexipril without checking with your doctor.
  • Moexipril may cause a serious side effect called angioedema. The risk may be higher in black patients. Contact your doctor at once if you develop swelling of the hands, face, lips, eyes, throat, or tongue; difficulty swallowing or breathing; or hoarseness.
  • Moexipril may not work as well in black patients. Contact your doctor if your symptoms do not improve or if they become worse.
  • Moexipril may cause a dry, unproductive cough. If caused by moexipril, this symptom usually stops after treatment with moexipril is stopped.
  • Tell your doctor or dentist that you take moexipril before you receive any medical or dental care, emergency care, or surgery.
  • Check with your doctor before you use a salt substitute or a product that has potassium in it.
  • Moexipril may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to moexipril. Use a sunscreen or wear protective clothing if you must be outside for more than short time.
  • Rarely, moexipril may lower the ability of your body to fight infection. This risk may be greater if you have certain other health problems (eg, kidney problems, collagen vascular disease). Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.
  • Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms.
  • If you have high blood pressure, do not use nonprescription products that contain stimulants. These products may include diet pills or cold medicines. Contact your doctor if you have any questions or concerns.
  • Lab tests, including kidney function, blood electrolyte levels, and blood pressure monitoring, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • Use moexipril with caution in the ELDERLY; they may be more sensitive to its effects.
  • Moexipril should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Moexipril may cause birth defects or fetal or newborn death if you take it while you are pregnant. If you think you may be pregnant, contact your doctor right away. It is not known if moexipril is found in breast milk. If you are or will be breast-feeding while you take moexipril, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of moexipril:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; dizziness; fatigue; flu-like symptoms; light-headedness when sitting or standing; persistent, dry cough.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing or swallowing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue; unusual hoarseness); chest pain; confusion; decreased urination; fainting; fast, slow, or irregular heartbeat; mental or mood changes; numbness of an arm or leg; one-sided weakness; severe or persistent dizziness or light-headedness; shortness of breath; slurred speech; stomach pain (with or without nausea or vomiting); sudden, severe headache or vomiting; swelling of the hands, ankles, or feet; symptoms of infection (eg, fever, chills, persistent sore throat); symptoms of liver problems (eg, dark urine, loss of appetite, pale stools, yellowing of the skin or eyes); vision changes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include fainting; severe dizziness or light-headedness.

Proper storage of moexipril:

Store moexipril at room temperature between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep moexipril out of the reach of children and away from pets.

General information:

  • If you have any questions about moexipril, please talk with your doctor, pharmacist, or other health care provider.
  • Moexipril is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take moexipril or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about moexipril. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to moexipril. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using moexipril.

Issue Date: July 2, 2014
Database Edition 14.3.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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