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perindopril

Pronunciation

Generic Name: perindopril (per IN doe pril)
Brand Name: Aceon

What is perindopril?

Perindopril is in a group of drugs called ACE inhibitors. ACE stands for angiotensin converting enzyme.

Perindopril is used to treat high blood pressure (hypertension) and to prevent heart attack in people with coronary artery disease.

Perindopril may also be used for purposes not listed in this medication guide.

What is the most important information I should know about perindopril?

Do not use perindopril if you are pregnant. Stop using this medication and tell your doctor right away if you become pregnant.

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You should not use perindopril if you have hereditary angioedema.

If you have diabetes, do not use perindopril together with any medication that contains aliskiren.

What should I discuss with my healthcare provider before taking perindopril?

Do not use this medication if you are allergic to perindopril or to any other ACE inhibitor, such as benazepril, captopril, enalapril, fosinopril , lisinopril, moexipril, quinapril, ramipril, or trandolapril.

If you have diabetes, do not use perindopril together with any medication that contains aliskiren (Amturnide, Tekturna, Tekamlo, Valturna).

You may also need to avoid taking perindopril with aliskiren if you have kidney disease.

You should not use perindopril if you have hereditary angioedema.

To make sure you can safely take perindopril, tell your doctor if you have any of these other conditions:

  • kidney disease (or if you are on dialysis);

  • liver disease;

  • heart disease or congestive heart failure;

  • diabetes; or

  • a connective tissue disease such as Marfan syndrome, Sjogren's syndrome, lupus, scleroderma, or rheumatoid arthritis.

FDA pregnancy category D. Do not use perindopril if you are pregnant. Stop using this medication and tell your doctor right away if you become pregnant. Perindopril can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. Use effective birth control while taking perindopril.

It is not known whether perindopril passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

How should I take perindopril?

Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Take each dose with a full glass of water. Drink plenty of liquids while you are taking perindopril.

Perindopril can be taken with or without food.

Conditions that may cause very low blood pressure include: vomiting, diarrhea, heavy sweating, heart disease, dialysis, a low salt diet, or taking diuretics (water pills). Tell your doctor if you have a prolonged illness that causes diarrhea or vomiting.

Your blood pressure will need to be checked often. Your kidney or liver function may also need to be checked.

If you need surgery, tell the surgeon ahead of time that you are using perindopril. You may need to stop using the medicine for a short time.

If you are being treated for high blood pressure, keep using this medication even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include feeling extremely dizzy or light-headed, or fainting.

What should I avoid while taking perindopril?

Drinking alcohol can further lower your blood pressure and may increase certain side effects of perindopril.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Do not use salt substitutes or potassium supplements while taking perindopril, unless your doctor has told you to.

Perindopril side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; severe stomach pain, difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;

  • fever, chills, body aches, flu symptoms, sores in your mouth and throat;

  • little or no urinating;

  • swelling, rapid weight gain;

  • high potassium (slow heart rate, weak pulse, muscle weakness, tingly feeling);

  • pale skin, easy bruising or bleeding; or

  • jaundice (yellowing of the skin or eyes).

Common side effects may include:

  • dizziness;

  • back pain; or

  • cough.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

Perindopril dosing information

Usual Adult Dose for Coronary Artery Disease:

Initial dose: 4 mg orally once a day for two weeks, then increased as tolerated to a maintenance dose of 8 mg orally once a day.
Maintenance dose: 4 mg to 8 mg orally once a day.

Usual Adult Dose for Congestive Heart Failure:

Initial dose: 4 mg orally once a day
Maintenance dose: 4 mg to 8 mg orally daily in one or two divided doses

Usual Adult Dose for Diabetic Nephropathy:

Initial dose: 4 mg orally once a day
Maintenance dose: 4 mg to 8 mg orally daily in one or two divided doses

Usual Adult Dose for Hypertension:

Initial dose: 4 mg orally once a day
Maintenance dose: 4 mg to 8 mg orally daily in one or two divided doses

Usual Adult Dose for Left Ventricular Dysfunction:

Initial dose: 4 mg orally once a day
Maintenance dose: 4 mg to 8 mg orally daily in one or two divided doses

Usual Adult Dose for Myocardial Infarction:

Initial dose: 4 mg orally once a day
Maintenance dose: 4 mg to 8 mg orally daily in one or two divided doses

Usual Geriatric Dose for Coronary Artery Disease:

Greater than 70 years:
Initial dose: 2 mg orally once a day in the first week, followed by 4 mg orally once a day in the second week, then 8 mg orally once a day for maintenance if tolerated.
Maintenance dose: 4 mg to 8 mg orally once a day.

What other drugs will affect perindopril?

Tell your doctor about all medicines you use, and those you start or stop using during your treatment with perindopril, especially:

  • gold injections to treat arthritis;

  • lithium;

  • NSAIDs (non-steroidal anti-inflammatory drugs)--ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others;

  • a potassium supplement;

  • salt substitutes that contain potassium; or

  • a diuretic or "water pill."

This list is not complete. Other drugs may interact with perindopril, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Where can I get more information?

  • Your pharmacist can provide more information about perindopril.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 5.01. Revision Date: 2013-03-20, 10:39:17 AM.

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