Moexipril Dosage

Usual Adult Dose for Congestive Heart Failure

Initial dose: 7.5 mg orally once a day, 1 hour prior to meals
(patients not receiving diuretics).
Maintenance dose: 7.5 to 30 mg/day orally in 1 to 2 divided doses 1 hour before meals.

Usual Adult Dose for Diabetic Nephropathy

Initial dose: 7.5 mg orally once a day, 1 hour prior to meals
(patients not receiving diuretics).
Maintenance dose: 7.5 to 30 mg/day orally in 1 to 2 divided doses 1 hour before meals.

Usual Adult Dose for Hypertension

Initial dose: 7.5 mg orally once a day, 1 hour prior to meals
(patients not receiving diuretics).
Maintenance dose: 7.5 to 30 mg/day orally in 1 to 2 divided doses 1 hour before meals.

Usual Adult Dose for Left Ventricular Dysfunction

Initial dose: 7.5 mg orally once a day, 1 hour prior to meals
(patients not receiving diuretics).
Maintenance dose: 7.5 to 30 mg/day orally in 1 to 2 divided doses 1 hour before meals.

Usual Adult Dose for Myocardial Infarction

Initial dose: 7.5 mg orally once a day, 1 hour prior to meals
(patients not receiving diuretics).
Maintenance dose: 7.5 to 30 mg/day orally in 1 to 2 divided doses 1 hour before meals.

Renal Dose Adjustments

CrCl less than 40 mL/min:
Initial dose: 3.75 mg orally once a day.
Doses may be titrated upward to a maximum daily dose of 15 mg.

Liver Dose Adjustments

Data not available

Dose Adjustments

The antihypertensive effect of moexipril may diminish towards the end of the dosing interval. Blood pressure should, therefore, be measured just prior to dosing to determine whether satisfactory blood pressure control is obtained. If control is not adequate, increased dose or divided dosing can be tried.

Precautions

In patients who are currently being treated with a diuretic, symptomatic hypotension may occasionally occur following the initial dose of moexipril. The diuretic should, if possible, be discontinued for 2 to 3 days before therapy with moexipril is begun, to reduce the likelihood of hypotension. If the patient's blood pressure is not controlled with moexipril alone, diuretic therapy may then be reinstituted. If diuretic therapy cannot be discontinued, an initial dose of 3.75 mg of moexipril should be used with medical supervision until blood pressure has stabilized.

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).

Dialysis

Data not available

Other Comments

Total daily doses above 60 mg a day have not been studied in hypertensive patients.

Compared with Caucasian patients, Black patients have a reduced blood pressure response to monotherapy with angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers; however, the reduced response is largely eliminated if combination therapy that includes an adequate dose of a diuretic is instituted.

Following first time MI, all ACE inhibitors, at comparable appropriate dosages, appear to be equally effective for reducing mortality and recurrent MI rates.

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