Moexipril Pregnancy and Breast Feeding Warnings
Moexipril is also known as: Univasc
Overview
When Moexipril is used after the third month of pregnancy, it can cause injury or even death to the developing fetus. Stop taking Moexipril as soon as possible if you become pregnant. If you think you may be pregnant, contact your doctor immediately. It is unknown if Moexipril is excreted in breast milk. If you are or will be breast-feeding while you are using Moexipril , check with your doctor or pharmacist to discuss the risks to your baby.
Moexipril Pregnancy Warnings
Moexipril has been assigned to pregnancy category D by the FDA for use during the second and third trimesters and to category C during the first trimester. Animal and human data have revealed evidence of embryolethality and teratogenicity associated with ACE inhibitors. There are no controlled data in human pregnancy. Congenital malformations have been reported with the use of ACE inhibitors during the first trimester of pregnancy, while fetal and neonatal toxicity, death, and congenital anomalies have been reported with the use of ACE inhibitors during the second and third trimesters of pregnancy. If the patient becomes pregnant, moexipril should be discontinued as soon as possible. Moexipril is considered contraindicated during pregnancy.
Drugs that act directly on the renin-angiotensin system can cause fetal and neonatal morbidity and death when administered during pregnancy. A committee of the National Institutes of Health has recommended that these drugs be avoided during pregnancy. Limited data have shown an association between major congenital malformations and the use of ACE inhibitors during the first trimester. In addition, the use of drugs that act directly on the renin-angiotensin system during the second and third trimesters of pregnancy has been associated with fetal and neonatal injury, including hypotension, neonatal skull hypoplasia, anuria, reversible or irreversible renal failure, and death. Oligohydramnios has also been reported, presumably resulting from decreased fetal limb contractures, craniofacial deformation, and hypoplastic lung development. Prematurity, intrauterine growth retardation, and patent ductus arteriosus have also been reported, although it is not clear whether these occurrences were due to exposure to the drug. Mothers whose embryos and fetuses are exposed to an ACE inhibitor during the first trimester should be informed of the risks. When pregnancy is detected or expected, moexipril should be discontinued as soon as possible.
Moexipril Lactation Warnings
There are no data on the excretion of moexipril into human milk. The manufacturer recommends that caution be used when administering moexipril to nursing women.
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