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Vitamin K1 Injection

This treatment applies to the following species:
Company: Neogen

Vitamin K Injection

(Phytonadione) 10 mg/mL

Aqueous Colloidal Solution of Vitamin K1



Severe reactions, including fatalities, have occurred during and immediately after INTRAVENOUS injection of Phytonadione, even when precautions have been taken to dilute the Vitamin K1 and to avoid rapid infusion. Typically, these severe reactions have resembled hypersensitivity or anaphylaxis, including shock and cardiac and or respiratory arrest. Some animals have exhibited these severe reactions on receiving Vitamin K1 Injection for the first time. Therefore, the intravenous route should be restricted to those situations where other routes are not feasible and the serious risk involved is considered justified.

See ADVERSE REACTION section for possible Intramuscular and Subcutaneous reactions.


Vitamin K1 Injection is a yellow, sterile, aqueous colloidal solution of Vitamin K1 (phytonadione), available for injection by the intravenous, intramuscular and subcutaneous routes.

Each mL contains:


10 mg

Emulphor EL-719

70 mg

Dextrose • H2O

41.2 mg

Benzyl Alcohol (preservative)


Water for Injection


ACTIONS: Vitamin K1 Injection, an aqueous colloidal solution of Vitamin K1 for parenteral injection, possesses the same type and degree of activity as does naturally occurring Vitamin K. The primary function of vitamin K is to stimulate the production via the liver of active prothrombin from a precursor protein. The mechanism by which vitamin K promotes formation of prothrombin at the molecular level has not been established.

The action of the aqueous colloidal solution, when administered intravenously, is generally detectable within an hour or two and hemorrhage is usually controlled within 3 to 6 hours. A normal prothrombin level may often be obtained in 12 to 14 hours.

Vitamin K1 Injection Indications

Vitamin K1 Injection is indicated in cattle, calves, horses, swine, sheep, goats, dogs and cats to counter Hypoprothrombinemia induced by ingestion of coumarin-based compounds, common ingredients in commercial rodenticides. Vitamin K1 Injection is also indicated to counter hypoprothrombinemia caused by consumption of Bishydroxycoumarin found in spoiled and moldy sweet clover.

NOTE: Regular determinations of prothrombin time response should be performed to guide in the initial and subsequent administration of Vitamin K1 Injection. The dosage should be adjusted accordingly.


Hypersensitivity to any component of this medication.


An immediate coagulant effect should not be expected after administration of phytonadione. A minimum of 1 to 2 hours is required for measurable improvement in the prothrombin time. Whole blood or component therapy may be necessary if the bleeding is severe.

Phytonadione will not counteract the anticoagulant action of heparin.

Repeated large doses of vitamin K are not warranted in hepatic disease if the response to the initial therapy is unsatisfactory. Failure to respond to vitamin K may indicate that the condition being treated is inherently unresponsive to vitamin K.


Protect from light at all times. Temporary resistance to prothrombin-depressing anticoagulants may result, especially when larger doses of phytonadione are used.

ADVERSE REACTION: Deaths have occurred following intravenous injection. (See Box Warning at Beginning of Circular).

Pain, swelling, and tenderness at the injection site may occur. The possibility of allergic sensitivity, including an anaphylactoid reaction, should be kept in mind.

Certain allergic manifestations, although rare, may occur following Intramuscular or Subcutaneous administration. These may include hives, urticaria, shortness of breath and edema.

Dosage and Administration

Cattle, Calves, Horses, Swine, Sheep, and Goats: Acute hypoprothrombinemia (with hemorrhage) - intravenously, 0.5 - 2.5 mg/kg body weight, at a rate not to exceed 10 mg/minute in mature animals and 5 mg/minute in newborn and very young animals. Non-acute hypoprothrombinemia - Intramuscularly or subcutaneously, 0.5 - 2.5 mg/kg body weight.

Dogs and Cats: Acute hypoprothrombinemia (with hemorrhage) and non-acute hypoprothrombinemia - 0.25 - 5 mg/kg subcutaneously OR intramuscularly. Use higher end of dose for second generation rodenticides.

Whenever possible, Vitamin K1 Injection should be given by the intramuscular or subcutaneous routes. When intravenous injection is considered unavoidable, the drug should be given very slowly, at the rate indicated above. MONITOR PROTHROMBIN TIME AND ADJUST DOSAGE ACCORDINGLY.

Frequency and amount of subsequent doses should be guided by regular determination of prothrombin time response and clinical condition. If in 6 to 8 hours after parenteral administration the prothrombin time has not been shortened satisfactorily, the dose should be repeated.

In the event of shock or excessive blood loss, the use of whole blood or component therapy is indicated. THE SMALLEST EFFECTIVE DOSE SHOULD BE SOUGHT TO MINIMIZE THE RISK OF ADVERSE REACTION.

DIRECTIONS FOR DILUTION: Vitamin K1 Injection may be diluted with 0.9% Sodium Chloride Injection, 5% Dextrose Injection, or 5% Dextrose w/Sodium Chloride Injection.

Other diluents should not be used. When dilutions are indicated, administration should be started immediately after mixture with the diluent, and unused portions of the dilution should be discarded.

Vitamin K1 Injection Caution

Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed veterinarian.

How Supplied

Vitamin K1 Injection is available in 100mL multiple dose vials.



Protect from light - store in dark place. Store at a temperature between 15° and 30° C (59° - 86° F).


Manufactured by: Sparhawk Laboratories, Lenexa, KS 66215

Manufactured for: Neogen Corporation, Lexington, KY 40511


Net Contents:


Item No.





Rev. 09-18


CPN: 1491018.6

Telephone:   859-254-1221
Order Desk:   800-525-2022
Fax:   859-255-5532
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